[{"data":1,"prerenderedAt":139},["ShallowReactive",2],{"drug-ropivacaine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":53,"warnings":63,"renal":71,"monitoring":72,"interactions":73,"review":74,"examples":77,"atc":78,"iran":80,"usApproval":87,"links":93,"populations":104},"ropivacaine",1,{"fa":7,"en":8},"روپیواکائین","Ropivacaine","nervous-system",{"fa":11,"en":12},"بی‌حس‌کننده موضعی آمیدی","Amide local anaesthetic",[14],{"name":15,"market":16},"Naropin","US",[18,19,7],"naropin","ناروپین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-5","injection","percutaneous","5 mg\u002FmL (0.5%), 30 mL vial",{"amount":27,"unit":28,"perVolumeMl":5},5,"mg",[16],[31],{"source":32,"section":33},"fda-naropin","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":50},"regional","local-anesthesia",{"fa":39,"en":40},"بی‌حسی جراحی (اپیدورال، بلوک اعصاب، انفیلتراسیون) و درد حاد (انفوزیون اپیدورال) بزرگسال — طبق جدول ۱","Surgical anaesthesia (epidural, nerve block, infiltration) and acute pain (epidural infusion), adults — per Table 1",{"minAge":42},{"value":43,"unit":44},18,"year","notCalculated",{"reason":47},{"fa":48,"en":49},"دوز به محل، غلظت و حجم بستگی دارد (جدول ۱ برچسب). تا ۷۷۰ mg در ۲۴ ساعت (حین عمل + انفوزیون پس از عمل) و انفوزیون اپیدورال تا ۲۸ mg\u002Fساعت به مدت ۷۲ ساعت تحمل شده است. آسپیره پیش از تزریق؛ دوز آزمایشی.","Dose depends on site, concentration and volume (label Table 1). Up to 770 mg over 24 h (intraoperative block plus postoperative infusion) and epidural infusion up to 28 mg\u002Fh for 72 h have been tolerated. Aspirate before injecting; use a test dose.",[51],{"source":32,"section":52},"2.2, Table 1",[54],{"id":55,"severity":56,"text":57,"refs":60},"hyper","block",{"fa":58,"en":59},"حساسیت به روپیواکائین یا سایر بی‌حس‌کننده‌های آمیدی.","Hypersensitivity to ropivacaine or other amide local anaesthetics.",[61],{"source":32,"section":62},"4",[64],{"text":65,"refs":68},{"fa":66,"en":67},"تزریق داخل‌عروقی ناخواسته (سمیت CNS و قلب)؛ کندرولیز با انفوزیون داخل مفصل؛ مت‌هموگلوبینمی؛ احتیاط در بیماری کبد و قلب.","Unintended intravascular injection (CNS and cardiac toxicity); chondrolysis with intra-articular infusion; methaemoglobinaemia; caution in hepatic and cardiac disease.",[69],{"source":32,"section":70},"5",[],[],[],{"status":75,"reviewer":76,"date":76},"unverified",null,[],[79],"N01BB09",{"status":81,"refs":82},"not-found",[83],{"source":84,"section":85,"url":86},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Ropivacaine",{"kind":88,"refs":89,"id":92},"NDA",[90],{"source":32,"section":91},"SPL approval \u002F marketing category","NDA020533",[94,97,101],{"kind":95,"url":96,"label":92},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020533",{"kind":98,"url":99,"label":100},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=cb6583ff-cde4-4280-aa5b-0bea2b844792","FDA Naropin",{"kind":102,"url":103,"label":79},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01BB09",{"pregnancy":105,"lactation":114,"pediatric":122,"geriatric":131},{"level":106,"text":107,"quote":110,"refs":111},"caution",{"fa":108,"en":109},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no available human data on use of Naropin (ropivacaine) Injection in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.",[112],{"source":32,"section":113},"8.1",{"level":106,"text":115,"quote":118,"refs":119},{"fa":116,"en":117},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary One publication reported that ropivacaine is present in human milk at low levels following administration of ropivacaine in women undergoing cesarean section.",[120],{"source":32,"section":121},"8.2",{"level":123,"text":124,"quote":127,"refs":128},"not-established",{"fa":125,"en":126},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and efficacy of NAROPIN in pediatric patients have not been established.",[129],{"source":32,"section":130},"8.4",{"level":106,"text":132,"quote":135,"refs":136},{"fa":133,"en":134},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Therefore, care should be taken in dose selection, starting at the low end of the dosage range, and it may be useful to monitor renal function [see Clinical Pharmacology ( 12.3 )] .",[137],{"source":32,"section":138},"8.5",1792444421852]