[{"data":1,"prerenderedAt":178},["ShallowReactive",2],{"drug-rasagiline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":42,"contraindications":81,"warnings":91,"renal":92,"monitoring":93,"interactions":94,"review":95,"examples":98,"atc":107,"iran":109,"usApproval":121,"links":127,"populations":143},"rasagiline",1,{"fa":7,"en":8},"رازاژیلین","Rasagiline","nervous-system",{"fa":11,"en":12},"مهارکننده MAO-B","MAO-B inhibitor",[14],{"name":15,"market":16},"Azilect","US",[18,19,7],"azilect","آزیلکت",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-0-5","tablet","oral","0.5 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},0.5,"mg",false,[16],[32],{"source":33,"section":34},"fda-rasagiline","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":39,"refs":40},"tab-1","1 mg tablet",{"amount":5,"unit":28,"perUnit":23,"scored":29},[16],[41],{"source":33,"section":34},[43,68],{"id":44,"disease":45,"label":46,"population":49,"type":53,"unit":28,"dose":54,"refs":55,"notes":58},"mono","parkinsons",{"fa":47,"en":48},"پارکینسون — تک‌درمانی یا همراه داروی غیر لوودوپا: ۱ mg یک بار در روز","Parkinson’s — monotherapy or with non-levodopa drugs: 1 mg once daily",{"minAge":50},{"value":51,"unit":52},18,"year","fixed",{"perDose":5,"dosesPerDay":5},[56],{"source":33,"section":57},"2.1",[59],{"text":60,"refs":63},{"fa":61,"en":62},"با سیپروفلوکساسین یا سایر مهارکننده‌های CYP1A2 و نارسایی خفیف کبد: ۰٫۵ mg؛ در نارسایی متوسط یا شدید کبد مصرف نشود.","With ciprofloxacin or other CYP1A2 inhibitors and in mild hepatic impairment: 0.5 mg; not for moderate or severe hepatic impairment.",[64,66],{"source":33,"section":65},"2.2",{"source":33,"section":67},"2.3",{"id":69,"disease":45,"label":70,"population":73,"type":53,"unit":28,"dose":75,"refs":76,"limits":78},"levodopa",{"fa":71,"en":72},"پارکینسون — همراه لوودوپا: ۰٫۵ mg یک بار در روز (تا ۱ mg)","Parkinson’s — with levodopa: 0.5 mg once daily (up to 1 mg)",{"minAge":74},{"value":51,"unit":52},{"perDose":27,"dosesPerDay":5},[77],{"source":33,"section":57},{"maxPerDose":5,"refs":79},[80],{"source":33,"section":57},[82],{"id":83,"severity":84,"text":85,"refs":88},"ci","block",{"fa":86,"en":87},"مپریدین، ترامادول، متادون، دکسترومتورفان، سیکلوبنزاپرین، علف چای و سایر MAOIها (۱۴ روز فاصله) — خطر سندرم سروتونین.","Meperidine, tramadol, methadone, dextromethorphan, cyclobenzaprine, St John’s wort and other MAOIs (14-day gap) — serotonin syndrome risk.",[89],{"source":33,"section":90},"4",[],[],[],[],{"status":96,"reviewer":97,"date":97},"unverified",null,[99,104],{"regimen":44,"formulation":36,"input":100,"expect":103},{"ageYears":101,"weightKg":102},65,70,{"perDose":5,"tabletsPerDoseRounded":5},{"regimen":69,"formulation":22,"input":105,"expect":106},{"ageYears":101,"weightKg":102},{"perDose":27,"tabletsPerDoseRounded":5},[108],"N04BD02",{"status":110,"forms":111,"refs":116},"registered",[112],{"code":113,"en":114,"fa":115},"09392","RASAGILINE 1MG TAB","قرص راساجیلین ۱ میلی‌گرم",[117],{"source":118,"section":119,"url":120},"darooyab-generic","G-4795\u002FRasagiline","https:\u002F\u002Fwww.darooyab.ir\u002FG-4795\u002FRasagiline",{"kind":122,"refs":123,"id":126},"ANDA",[124],{"source":33,"section":125},"SPL approval \u002F marketing category","ANDA201970",[128,131,135,138,141],{"kind":129,"url":130,"label":126},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=201970",{"kind":132,"url":133,"label":134},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a62a9946-755f-47d0-afe6-edc8f7d641fe","FDA Rasagiline",{"kind":136,"url":137,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa606017.html",{"kind":139,"url":140,"label":108},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N04BD02",{"kind":142,"url":120,"label":8},"darooyab",{"pregnancy":144,"lactation":153,"pediatric":161,"geriatric":170},{"level":145,"text":146,"quote":149,"refs":150},"caution",{"fa":147,"en":148},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risks associated with the use of rasagiline in pregnant women.",[151],{"source":33,"section":152},"8.1",{"level":145,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of rasagiline in human milk or the effects on the breastfed infant.",[159],{"source":33,"section":160},"8.2",{"level":162,"text":163,"quote":166,"refs":167},"not-established",{"fa":164,"en":165},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness in pediatric patients have not been established.",[168],{"source":33,"section":169},"8.4",{"level":145,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Approximately half of patients in clinical trials were 65 years and over.",[176],{"source":33,"section":177},"8.5",1792115194425]