[{"data":1,"prerenderedAt":176},["ShallowReactive",2],{"drug-rabies-immune-globulin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":49,"contraindications":76,"warnings":77,"renal":78,"monitoring":79,"interactions":80,"review":81,"examples":84,"atc":101,"iran":103,"links":121,"populations":136,"usApproval":171},"rabies-immune-globulin",1,{"fa":7,"en":8},"ایمونوگلوبولین هاری (HRIG)","Rabies immune globulin (human)","anti-infectives",{"fa":11,"en":12},"ایمونوگلوبولین اختصاصی","Specific immune globulin",[14],{"name":15,"market":16},"HyperRAB","US",[18,19,20,21],"hyperrab","HRIG","سرم ضد هاری","ایمونوگلوبولین هاری",[23,36],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"vial-300","injection","im","300 IU\u002FmL (1, 3, 5 mL vials)",{"amount":29,"unit":30,"perVolumeMl":5},300,"unit",[16],[33],{"source":34,"section":35},"fda-hyperrab","3",{"id":37,"form":25,"route":26,"label":38,"concentration":39,"markets":41,"refs":43},"vial-150","150 IU\u002FmL (older\u002Fother products, e.g. sold in Iran) — check the vial strength",{"amount":40,"unit":30,"perVolumeMl":5},150,[42],"IR",[44,46],{"source":34,"section":45},"2.2",{"source":47,"section":48},"darooyab-generic","G-3504\u002FRabies-Immunoglobulins",[50],{"id":51,"disease":52,"label":53,"population":56,"type":57,"unit":30,"dose":58,"refs":60,"limits":63,"durationDays":66,"notes":67},"pep","rabies-exposure",{"fa":54,"en":55},"پیشگیری پس از تماس با هاری — ۲۰ IU\u002Fkg یک بار (همه سنین)","Rabies post-exposure prophylaxis — 20 IU\u002Fkg once (all ages)",{},"weightBased",{"perKgPerDay":59,"dividedDoses":5},20,[61],{"source":34,"section":62},"2.1",{"maxPerKgPerDose":59,"refs":64},[65],{"source":34,"section":62},{"min":5,"max":5},[68],{"text":69,"refs":72},{"fa":70,"en":71},"فقط برای افرادی که قبلاً واکسن نزده‌اند، همراه واکسن (روز ۰ و حداکثر تا روز ۷). تا جای ممکن کل دوز داخل و اطراف زخم تزریق شود؛ باقی‌مانده عضلانی دور از محل واکسن. بیشتر از دوز توصیه‌شده نشود (پاسخ واکسن را کم می‌کند).","Only for previously unvaccinated people, together with vaccine (day 0, no later than day 7). Infiltrate as much as possible into and around the wound; the rest IM away from the vaccine site. Do not exceed the dose (it blunts the vaccine response).",[73,74],{"source":34,"section":62},{"source":34,"section":75},"2.3",[],[],[],[],[],{"status":82,"reviewer":83,"date":83},"unverified",null,[85,92,97],{"regimen":51,"formulation":24,"input":86,"expect":89},{"ageYears":87,"weightKg":88},30,70,{"perDose":90,"mlPerDose":91},1400,4.67,{"regimen":51,"formulation":24,"input":93,"expect":96},{"ageYears":94,"weightKg":95},3,15,{"perDose":29,"mlPerDose":5},{"regimen":51,"formulation":37,"input":98,"expect":99},{"ageYears":87,"weightKg":88},{"perDose":90,"mlPerDose":100},9.33,[102],"J06BB05",{"status":104,"forms":105,"refs":118},"registered",[106,110,114],{"code":107,"en":108,"fa":109},"01092","RABIES IMMUNE GLOBULIN 300U VIAL","ویال هاری ایمونوگلوبولین ۳۰۰ واحد",{"code":111,"en":112,"fa":113},"01945","RABIES IMMUNE GLOBULIN FROM PLASMA INF","محلول انفوزیون هاری ایمونوگلوبولین فروم پلاسما",{"code":115,"en":116,"fa":117},"50927","RABIES IMMUNE GLOBULIN INJECTION PARENTERAL 150 [iU]\u002F1mL 5 mL","فرآورده تزریقی هاری ایمونوگلوبولین ۱۵۰ واحد بین‌المللی \u002F ۱ میلی‌لیتر ۵ میلی‌لیتر",[119],{"source":47,"section":48,"url":120},"https:\u002F\u002Fwww.darooyab.ir\u002FG-3504\u002FRabies-Immunoglobulins",[122,126,130,133],{"kind":123,"url":124,"label":125},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=101144","BLA101144",{"kind":127,"url":128,"label":129},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f82880b8-998c-4659-8f20-6dcc81f258e9","FDA HyperRAB",{"kind":131,"url":132,"label":102},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J06BB05",{"kind":134,"url":120,"label":135},"darooyab","Rabies-Immunoglobulins",{"pregnancy":137,"lactation":146,"pediatric":154,"geriatric":163},{"level":138,"text":139,"quote":142,"refs":143},"caution",{"fa":140,"en":141},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no data with HYPERRAB use in pregnant women to inform a drug-associated risk.",[144],{"source":34,"section":145},"8.1",{"level":138,"text":147,"quote":150,"refs":151},{"fa":148,"en":149},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information regarding the presence of HYPERRAB in human milk, the effect on the breastfed infant, or the effects on milk production.",[152],{"source":34,"section":153},"8.2",{"level":155,"text":156,"quote":159,"refs":160},"not-established",{"fa":157,"en":158},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in the pediatric population have not been established.",[161],{"source":34,"section":162},"8.4",{"level":138,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Safety and effectiveness in geriatric population have not been established.",[169],{"source":34,"section":170},"8.5",{"kind":172,"refs":173,"id":125},"BLA",[174],{"source":34,"section":175},"SPL approval \u002F marketing category",1792108435686]