[{"data":1,"prerenderedAt":348},["ShallowReactive",2],{"drug-propofol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":197,"warnings":207,"renal":215,"monitoring":216,"interactions":217,"review":218,"examples":221,"atc":261,"iran":263,"usApproval":291,"links":297,"populations":314},"propofol",1,{"fa":7,"en":8},"پروپوفول","Propofol","nervous-system",{"fa":11,"en":12},"بیهوش‌کننده وریدی","IV general anaesthetic",[14],{"name":15,"market":16},"Diprivan","US",[18,19,7],"diprivan","دیپریوان",[21,34],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"em-10","injection","iv","10 mg\u002FmL emulsion (10, 20, 50, 100 mL vials)",{"amount":27,"unit":28,"perVolumeMl":5},10,"mg",[16],[31],{"source":32,"section":33},"fda-diprivan","3",{"id":35,"form":23,"route":24,"label":36,"concentration":37,"markets":40,"refs":41},"em-10-mcg","10 mg\u002FmL emulsion = 10,000 mcg\u002FmL (for infusion rate)",{"amount":38,"unit":39,"perVolumeMl":5},10000,"mcg",[16],[42],{"source":32,"section":33},[44,82,100,130,152,174],{"id":45,"disease":46,"label":47,"population":50,"type":56,"unit":28,"dose":57,"refs":61,"durationDays":66,"allowedFormulations":67,"notes":68},"ind-adult","general-anesthesia",{"fa":48,"en":49},"القای بیهوشی — بزرگسال سالم زیر ۶۵ سال: ۲ تا ۲٫۵ mg\u002Fkg تا شروع اثر","Induction — healthy adult \u003C65 y: 2–2.5 mg\u002Fkg titrated to onset",{"minAge":51,"maxAge":54},{"value":52,"unit":53},18,"year",{"value":55,"unit":53},65,"weightBased",{"perKgPerDose":58,"perKgPerDoseMax":59,"intervalHours":60},2,2.5,24,[62,64],{"source":32,"section":63},"2.7, Table 1",{"source":32,"section":65},"2.2",{"min":5,"max":5},[22],[69,76],{"text":70,"refs":73},{"fa":71,"en":72},"فقط توسط فرد آموزش‌دیده در بیهوشی با امکانات کنترل راه هوایی، اکسیژن و احیا.","Only by persons trained in anaesthesia, with airway management, oxygen and resuscitation available.",[74],{"source":32,"section":75},"2.1",{"text":77,"refs":80},{"fa":78,"en":79},"سالمند، ناتوان یا ASA III\u002FIV: ۱ تا ۱٫۵ mg\u002Fkg؛ بیهوشی قلب: ۰٫۵ تا ۱٫۵؛ جراحی اعصاب: ۱ تا ۲ mg\u002Fkg. بولوس سریع در سالمند نه.","Elderly, debilitated or ASA III\u002FIV: 1–1.5 mg\u002Fkg; cardiac: 0.5–1.5; neurosurgical: 1–2 mg\u002Fkg. No rapid boluses in the elderly.",[81],{"source":32,"section":63},{"id":83,"disease":46,"label":84,"population":87,"type":56,"unit":28,"dose":89,"refs":91,"durationDays":93,"allowedFormulations":94,"notes":95},"ind-elderly",{"fa":85,"en":86},"القای بیهوشی — سالمند، ناتوان یا ASA III\u002FIV: ۱ تا ۱٫۵ mg\u002Fkg","Induction — elderly, debilitated or ASA III\u002FIV: 1–1.5 mg\u002Fkg",{"minAge":88},{"value":55,"unit":53},{"perKgPerDose":5,"perKgPerDoseMax":90,"intervalHours":60},1.5,[92],{"source":32,"section":63},{"min":5,"max":5},[22],[96],{"text":97,"refs":98},{"fa":71,"en":72},[99],{"source":32,"section":75},{"id":101,"disease":46,"label":102,"population":105,"type":56,"unit":28,"dose":110,"refs":112,"durationDays":115,"allowedFormulations":116,"notes":117},"ind-child",{"fa":103,"en":104},"القای بیهوشی — کودک سالم ۳ تا ۱۶ سال: ۲٫۵ تا ۳٫۵ mg\u002Fkg","Induction — healthy child 3–16 y: 2.5–3.5 mg\u002Fkg",{"minAge":106,"maxAge":108},{"value":107,"unit":53},3,{"value":109,"unit":53},17,{"perKgPerDose":59,"perKgPerDoseMax":111,"intervalHours":60},3.5,[113,114],{"source":32,"section":63},{"source":32,"section":65},{"min":5,"max":5},[22],[118,122],{"text":119,"refs":120},{"fa":71,"en":72},[121],{"source":32,"section":75},{"text":123,"refs":126},{"fa":124,"en":125},"کودکان کوچک‌تر ممکن است دوز بیشتری لازم داشته باشند. ایمنی القا زیر ۳ سال ثابت نشده است.","Younger children may need higher doses. Induction safety under 3 y not established.",[127,128],{"source":32,"section":65},{"source":32,"section":129},"2.7",{"id":131,"disease":46,"label":132,"population":135,"type":138,"unit":39,"dose":139,"refs":142,"allowedFormulations":144,"notes":145},"maint",{"fa":133,"en":134},"نگهداری بیهوشی — بزرگسال سالم: ۱۰۰ تا ۲۰۰ mcg\u002Fkg\u002Fدقیقه","Maintenance — healthy adult: 100–200 mcg\u002Fkg\u002Fmin",{"minAge":136,"maxAge":137},{"value":52,"unit":53},{"value":55,"unit":53},"infusion",{"perKgPerMin":140,"perKgPerMinMax":141},100,200,[143],{"source":32,"section":63},[35],[146],{"text":147,"refs":150},{"fa":148,"en":149},"سالمند یا ASA III\u002FIV: ۵۰ تا ۱۰۰ mcg\u002Fkg\u002Fدقیقه؛ بیهوشی قلب: ۲۵ تا ۱۰۰. کودک ۲ ماه تا ۱۶ سال: انفوزیون جداگانه طبق جدول برچسب.","Elderly or ASA III\u002FIV: 50–100 mcg\u002Fkg\u002Fmin; cardiac: 25–100. Children 2 months–16 y: separate infusion per label table.",[151],{"source":32,"section":63},{"id":153,"disease":154,"label":155,"population":158,"type":138,"unit":39,"dose":160,"refs":163,"allowedFormulations":166,"notes":167},"mac","icu-sedation",{"fa":156,"en":157},"آرام‌بخشی حین پروسیجر (MAC) — بزرگسال: ۲۵ تا ۷۵ mcg\u002Fkg\u002Fدقیقه","Monitored anaesthesia care sedation — adult: 25–75 mcg\u002Fkg\u002Fmin",{"minAge":159},{"value":52,"unit":53},{"perKgPerMin":161,"perKgPerMinMax":162},25,75,[164],{"source":32,"section":165},"2.4",[35],[168],{"text":169,"refs":172},{"fa":170,"en":171},"شروع با انفوزیون یا تزریق آهسته، نه بولوس سریع.","Start with a slow infusion or slow injection, not a rapid bolus.",[173],{"source":32,"section":165},{"id":175,"disease":154,"label":176,"population":179,"type":138,"unit":39,"dose":181,"refs":184,"allowedFormulations":188,"notes":189},"icu",{"fa":177,"en":178},"آرام‌بخشی ICU بیمار اینتوبه — شروع ۵ mcg\u002Fkg\u002Fدقیقه، افزایش ۵ تا ۱۰ هر ۵ تا ۱۰ دقیقه","ICU sedation of intubated adults — start 5 mcg\u002Fkg\u002Fmin, increase by 5–10 every 5–10 min",{"minAge":180},{"value":52,"unit":53},{"perKgPerMin":182,"perKgPerMinMax":183},5,50,[185,186],{"source":32,"section":63},{"source":32,"section":187},"2.6",[35],[190],{"text":191,"refs":194},{"fa":192,"en":193},"شروع ۵ mcg\u002Fkg\u002Fدقیقه دست‌کم ۵ دقیقه؛ افزایش تا رسیدن به سطح آرام‌بخشی. تغییر سرعت آهسته (بیش از ۵ دقیقه) برای پیشگیری از افت فشار. چربی خون پایش شود.","Start 5 mcg\u002Fkg\u002Fmin for at least 5 min; increase until the desired sedation. Change rates slowly (>5 min) to avoid hypotension. Monitor blood lipids.",[195,196],{"source":32,"section":63},{"source":32,"section":187},[198],{"id":199,"severity":200,"text":201,"refs":204},"hyper","block",{"fa":202,"en":203},"حساسیت به پروپوفول یا اجزای آن؛ سابقه آنافیلاکسی به تخم‌مرغ یا سویا.","Hypersensitivity to propofol or its components; history of anaphylaxis to eggs or soy.",[205],{"source":32,"section":206},"4",[208],{"text":209,"refs":212},{"fa":210,"en":211},"افت فشار و دپرسیون تنفسی؛ سندرم انفوزیون پروپوفول در دوز بالا و طولانی؛ امولسیون چربی — رعایت سترونی (رشد میکروب).","Hypotension and respiratory depression; propofol infusion syndrome with high-dose prolonged use; lipid emulsion — strict asepsis (supports microbial growth).",[213],{"source":32,"section":214},"5",[],[],[],{"status":219,"reviewer":220,"date":220},"unverified",null,[222,230,234,239,246,253],{"regimen":45,"formulation":22,"input":223,"expect":226},{"ageYears":224,"weightKg":225},40,70,{"perDose":227,"mlPerDose":228,"upperPerDose":229},140,14,175,{"regimen":83,"formulation":22,"input":231,"expect":232},{"ageYears":162,"weightKg":225},{"perDose":225,"mlPerDose":233},7,{"regimen":101,"formulation":22,"input":235,"expect":238},{"ageYears":236,"weightKg":237},6,20,{"perDose":183,"mlPerDose":182,"upperPerDose":225},{"regimen":131,"formulation":35,"input":240,"expect":241},{"ageYears":224,"weightKg":225},{"perMin":242,"mlPerHour":243,"upperPerMin":244,"upperMlPerHour":245},7000,42,14000,84,{"regimen":153,"formulation":35,"input":247,"expect":248},{"ageYears":224,"weightKg":225},{"perMin":249,"mlPerHour":250,"upperPerMin":251,"upperMlPerHour":252},1750,10.5,5250,31.5,{"regimen":175,"formulation":35,"input":254,"expect":256},{"ageYears":255,"weightKg":225},60,{"perMin":257,"mlPerHour":258,"upperPerMin":259,"upperMlPerHour":260},350,2.1,3500,21,[262],"N01AX10",{"status":264,"forms":265,"refs":286},"registered",[266,270,274,278,282],{"code":267,"en":268,"fa":269},"01952","PROPOFOL 1000MG\u002F100ML VIAL","ویال پروپوفول ۱۰۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":271,"en":272,"fa":273},"16873","PROPOFOL 2% 50ML VIAL","ویال پروپوفول ۲ درصد ۵۰ میلی‌لیتر",{"code":275,"en":276,"fa":277},"18940","PROPOFOL 200MG\u002F20ML AMP.","آمپول پروپوفول ۲۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر .",{"code":279,"en":280,"fa":281},"01653","PROPOFOL 200MG\u002F20ML VIAL","ویال پروپوفول ۲۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":283,"en":284,"fa":285},"01951","PROPOFOL 500MG\u002F50ML VIAL","ویال پروپوفول ۵۰۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",[287],{"source":288,"section":289,"url":290},"darooyab-generic","G-2676\u002FPropofol","https:\u002F\u002Fwww.darooyab.ir\u002FG-2676\u002FPropofol",{"kind":292,"refs":293,"id":296},"NDA",[294],{"source":32,"section":295},"SPL approval \u002F marketing category","NDA019627",[298,301,305,309,312],{"kind":299,"url":300,"label":296},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019627",{"kind":302,"url":303,"label":304},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e3105799-a4b6-f3f4-e6e2-b2b29bbdb538","FDA Diprivan",{"kind":306,"url":307,"label":308},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625006.html","Propofol Injection",{"kind":310,"url":311,"label":262},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01AX10",{"kind":313,"url":290,"label":8},"darooyab",{"pregnancy":315,"lactation":324,"pediatric":332,"geriatric":340},{"level":316,"text":317,"quote":320,"refs":321},"caution",{"fa":318,"en":319},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Data from randomized controlled trials, cohort studies and case series over several decades with propofol use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[322],{"source":32,"section":323},"8.1",{"level":316,"text":325,"quote":328,"refs":329},{"fa":326,"en":327},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Based on data from published studies, propofol is present in human milk.",[330],{"source":32,"section":331},"8.2",{"level":316,"text":333,"quote":336,"refs":337},{"fa":334,"en":335},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of DIPRIVAN have been established for induction of anesthesia in pediatric patients aged 3 years and older and for the maintenance of anesthesia aged 2 months and older.",[338],{"source":32,"section":339},"8.4",{"level":316,"text":341,"quote":344,"refs":345},{"fa":342,"en":343},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The effect of age on induction dose requirements for propofol was assessed in an open-label study involving 211 unpremedicated patients with approximately 30 patients in each decade between the ages of 16 and 80.",[346],{"source":32,"section":347},"8.5",1792156192879]