[{"data":1,"prerenderedAt":188},["ShallowReactive",2],{"drug-primidone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":89,"warnings":99,"renal":107,"monitoring":108,"interactions":109,"review":110,"examples":113,"atc":126,"iran":128,"usApproval":148,"links":154,"populations":170},"primidone",1,{"fa":7,"en":8},"پریمیدون","Primidone","nervous-system",{"fa":11,"en":12},"ضدتشنج (دئوکسی‌باربیتورات)","Antiseizure (deoxybarbiturate)",[14],{"name":15,"market":16},"Mysoline","US",[18,19,7],"mysoline","مایزولین",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-250","tablet","oral","250 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},250,"mg",true,[16],[32],{"source":33,"section":34},"fda-primidone","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-50","50 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":29},50,[16],[42],{"source":33,"section":34},[44,71],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":57,"limits":60,"notes":64},"adult","epilepsy",{"fa":48,"en":49},"صرع (تونیک-کلونیک، سایکوموتور، فوکال) — ۸ سال به بالا: نگهدارنده ۲۵۰ mg سه بار در روز","Epilepsy (tonic-clonic, psychomotor, focal) — ≥8 y: maintenance 250 mg three times daily",{"minAge":51},{"value":52,"unit":53},8,"year","fixed",{"perDose":27,"dosesPerDay":56},3,[58],{"source":33,"section":59},"Dosage and Administration",{"maxPerDay":61,"refs":62},2000,[63],{"source":33,"section":59},[65],{"text":66,"refs":69},{"fa":67,"en":68},"شروع ۱۰۰ تا ۱۲۵ mg هنگام خواب و طی ۱۰ روز افزایش (روز ۴: دو بار، روز ۷: سه بار، روز ۱۰: ۲۵۰ mg سه بار). معمولاً ۷۵۰ تا ۱۰۰۰ mg\u002Fروز؛ حداکثر ۵۰۰ mg چهار بار. سطح سرمی مؤثر ۵ تا ۱۲ µg\u002FmL.","Start 100–125 mg at bedtime and build over 10 days (day 4: twice, day 7: three times, day 10: 250 mg three times). Usually 750–1000 mg\u002Fday; max 500 mg four times daily. Effective serum level 5–12 µg\u002FmL.",[70],{"source":33,"section":59},{"id":72,"disease":46,"label":73,"population":76,"type":54,"unit":28,"dose":78,"refs":80,"notes":82},"child",{"fa":74,"en":75},"کودک زیر ۸ سال — نگهدارنده ۱۲۵ تا ۲۵۰ mg سه بار در روز","Children under 8 y — maintenance 125–250 mg three times daily",{"maxAge":77},{"value":52,"unit":53},{"perDose":79,"perDoseMax":27,"dosesPerDay":56},125,[81],{"source":33,"section":59},[83],{"text":84,"refs":87},{"fa":85,"en":86},"یا ۱۰ تا ۲۵ mg\u002Fkg\u002Fروز تقسیمی. شروع ۵۰ mg هنگام خواب؛ روز ۴: ۵۰ mg دو بار؛ روز ۷: ۱۰۰ mg دو بار؛ روز ۱۰: نگهدارنده.","Or 10–25 mg\u002Fkg\u002Fday divided. Start 50 mg at bedtime; day 4: 50 mg twice; day 7: 100 mg twice; day 10: maintenance.",[88],{"source":33,"section":59},[90],{"id":91,"severity":92,"text":93,"refs":96},"ci","block",{"fa":94,"en":95},"پورفیری؛ حساسیت به فنوباربیتال.","Porphyria; hypersensitivity to phenobarbital.",[97],{"source":33,"section":98},"Contraindications",[100],{"text":101,"refs":104},{"fa":102,"en":103},"قطع ناگهانی ممکن است استاتوس صرعی ایجاد کند؛ اثر درمانی چند هفته طول می‌کشد.","Abrupt withdrawal may precipitate status epilepticus; therapeutic efficacy takes several weeks to assess.",[105],{"source":33,"section":106},"Warnings",[],[],[],{"status":111,"reviewer":112,"date":112},"unverified",null,[114,120],{"regimen":45,"formulation":22,"input":115,"expect":118},{"ageYears":116,"weightKg":117},30,70,{"perDose":27,"tabletsPerDoseRounded":5,"perDay":119},750,{"regimen":72,"formulation":22,"input":121,"expect":124},{"ageYears":122,"weightKg":123},5,18,{"perDose":79,"tabletsPerDoseRounded":125,"upperPerDose":27},0.5,[127],"N03AA03",{"status":129,"forms":130,"refs":143},"registered",[131,135,139],{"code":132,"en":133,"fa":134},"01650","PRIMIDONE 125MG\u002F5ML 250ML SUSP","سوسپانسیون پریمیدون ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",{"code":136,"en":137,"fa":138},"01051","PRIMIDONE 250MG TAB","قرص پریمیدون ۲۵۰ میلی‌گرم",{"code":140,"en":141,"fa":142},"01052","PRIMIDONE 250MG\u002F5ML SUSP","سوسپانسیون پریمیدون ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",[144],{"source":145,"section":146,"url":147},"darooyab-generic","G-681\u002FPrimidone","https:\u002F\u002Fwww.darooyab.ir\u002FG-681\u002FPrimidone",{"kind":149,"refs":150,"id":153},"ANDA",[151],{"source":33,"section":152},"SPL approval \u002F marketing category","ANDA040586",[155,158,162,165,168],{"kind":156,"url":157,"label":153},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040586",{"kind":159,"url":160,"label":161},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=14f9aee1-4d3e-45e0-ad5c-70bd98667adc","FDA Primidone",{"kind":163,"url":164,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682023.html",{"kind":166,"url":167,"label":127},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AA03",{"kind":169,"url":147,"label":8},"darooyab",{"pregnancy":171,"lactation":180},{"level":172,"text":173,"quote":176,"refs":177},"caution",{"fa":174,"en":175},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","To provide information regarding the effects of in utero exposure to primidone, physicians are advised to recommend that pregnant patients taking primidone enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry.",[178],{"source":33,"section":179},"Pregnancy",{"level":172,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","There is evidence in mothers treated with primidone, the drug appears in the milk in substantial quantities.",[186],{"source":33,"section":187},"Nursing Mothers",1792191562577]