[{"data":1,"prerenderedAt":189},["ShallowReactive",2],{"drug-pramlintide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":84,"warnings":94,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110,"atc":122,"iran":124,"links":131,"populations":149,"usApproval":184},"pramlintide",1,{"fa":7,"en":8},"پراملینتاید","Pramlintide","alimentary-metabolism",{"fa":11,"en":12},"آنالوگ آمیلین","Amylin analogue",[14],{"name":15,"market":16},"Symlin","US",[18,19,20],"symlin","سیملین","پراملینتید",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"pen-1000","injection","sc","1000 mcg\u002FmL SymlinPen (dial the mcg dose on the pen; do not measure by mL)",{"amount":28,"unit":29,"perVolumeMl":5},1000,"mcg",[16],[32],{"source":33,"section":34},"fda-symlin","3",[36,64],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":50,"durationDays":53,"notes":54},"t2","type-2-diabetes",{"fa":40,"en":41},"دیابت نوع ۲ با انسولین وعده — ۶۰ mcg پیش از هر وعده اصلی؛ تا ۱۲۰ mcg","Type 2 diabetes on mealtime insulin — 60 mcg before each major meal; up to 120 mcg",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":48,"perDoseMax":49,"dosesPerDay":5},60,120,[51],{"source":33,"section":52},"2.2",{"min":5,"max":5},[55],{"text":56,"refs":59},{"fa":57,"en":58},"هنگام شروع، انسولین وعده ۵۰٪ کم شود. فقط پیش از وعده اصلی (≥۲۵۰ kcal یا ≥۳۰ g کربوهیدرات)، شکم یا ران، جدا از انسولین. دست‌کم ۳ روز بین افزایش‌ها.","On initiation reduce mealtime insulin by 50%. Only before major meals (≥250 kcal or ≥30 g carbohydrate), abdomen or thigh, separate from insulin. At least 3 days between titration steps.",[60,62],{"source":33,"section":61},"2.1",{"source":33,"section":63},"2.4",{"id":65,"disease":66,"label":67,"population":70,"type":46,"unit":29,"dose":72,"refs":74,"durationDays":77,"notes":78},"t1","type-1-diabetes",{"fa":68,"en":69},"دیابت نوع ۱ — ۱۵ mcg پیش از هر وعده اصلی؛ با گام ۱۵ تا ۳۰ (حداکثر ۶۰) mcg","Type 1 diabetes — 15 mcg before each major meal; steps of 15 to 30 (max 60) mcg",{"minAge":71},{"value":44,"unit":45},{"perDose":73,"perDoseMax":48,"dosesPerDay":5},15,[75],{"source":33,"section":76},"2.3",{"min":5,"max":5},[79],{"text":80,"refs":81},{"fa":57,"en":58},[82,83],{"source":33,"section":61},{"source":33,"section":63},[85],{"id":86,"severity":87,"text":88,"refs":91},"ci","block",{"fa":89,"en":90},"حساسیت جدی؛ عدم درک هیپوگلیسمی؛ گاستروپارزی تأییدشده.","Serious hypersensitivity; hypoglycaemia unawareness; confirmed gastroparesis.",[92],{"source":33,"section":93},"4",[95],{"text":96,"refs":99},{"fa":97,"en":98},"هشدار جعبه‌ای: هیپوگلیسمی شدید با انسولین، به‌ویژه دیابت نوع ۱، ظرف ۳ ساعت پس از تزریق. هرگز با انسولین مخلوط نشود.","Boxed warning: severe hypoglycaemia with insulin, especially type 1, within 3 h of injection. Never mix with insulin.",[100,102],{"source":33,"section":101},"Boxed Warning",{"source":33,"section":103},"5.4",[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111,117],{"regimen":37,"formulation":23,"input":112,"expect":115},{"ageYears":113,"weightKg":114},55,90,{"perDose":48,"mlPerDose":116,"upperPerDose":49},0.06,{"regimen":65,"formulation":23,"input":118,"expect":121},{"ageYears":119,"weightKg":120},30,70,{"perDose":73,"upperPerDose":48},[123],"A10BX05",{"status":125,"refs":126},"not-found",[127],{"source":128,"section":129,"url":130},"darooyab-generic","G-647\u002FPramlintide","https:\u002F\u002Fwww.darooyab.ir\u002FG-647\u002FPramlintide",[132,136,140,144,147],{"kind":133,"url":134,"label":135},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021332","NDA021332",{"kind":137,"url":138,"label":139},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4aea30ff-eb0d-45c1-b114-3127966328ff","FDA Symlin",{"kind":141,"url":142,"label":143},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605031.html","Pramlintide Injection",{"kind":145,"url":146,"label":123},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A10BX05",{"kind":148,"url":130,"label":8},"darooyab",{"pregnancy":150,"lactation":159,"pediatric":167,"geriatric":176},{"level":151,"text":152,"quote":155,"refs":156},"caution",{"fa":153,"en":154},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from a small number of reports in the manufacturer’s safety database on SYMLIN use in pregnant women are not sufficient to determine a drug-associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes.",[157],{"source":33,"section":158},"8.1",{"level":151,"text":160,"quote":163,"refs":164},{"fa":161,"en":162},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no data on the presence of pramlintide in human milk, the effects on the breastfed infant, or the effects on milk production.",[165],{"source":33,"section":166},"8.2",{"level":168,"text":169,"quote":172,"refs":173},"not-established",{"fa":170,"en":171},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of SYMLIN in pediatric patients have not been established.",[174],{"source":33,"section":175},"8.4",{"level":151,"text":177,"quote":180,"refs":181},{"fa":178,"en":179},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","SYMLIN has been studied in patients ranging in age from 15 to 84 years of age, including 769 patients ≥65 to 75 years of age and 87 patients ≥75 years of age.",[182],{"source":33,"section":183},"8.5",{"kind":185,"refs":186,"id":135},"NDA",[187],{"source":33,"section":188},"SPL approval \u002F marketing category",1792191562160]