[{"data":1,"prerenderedAt":156},["ShallowReactive",2],{"drug-pimozide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":43,"contraindications":59,"warnings":69,"renal":78,"monitoring":79,"interactions":80,"review":81,"examples":84,"atc":85,"iran":87,"usApproval":107,"links":113,"populations":129},"pimozide",1,{"fa":7,"en":8},"پیموزاید","Pimozide","nervous-system",{"fa":11,"en":12},"دی‌فنیل‌بوتیل‌پیپریدین (ضدروان‌پریشی)","Diphenylbutylpiperidine antipsychotic",[14],{"name":15,"market":16},"Orap","US",[18,19,20],"orap","اوراپ","پیموزید",[22,35],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"tab-1","tablet","oral","1 mg tablet (scored)",{"amount":5,"unit":28,"perUnit":24,"scored":29},"mg",true,[16],[32],{"source":33,"section":34},"fda-pimozide","How Supplied",{"id":36,"form":24,"route":25,"label":37,"concentration":38,"markets":40,"refs":41},"tab-2","2 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":24,"scored":29},2,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":51,"unit":28,"dose":52,"refs":56},"tour","tourette",{"fa":48,"en":49},"سندرم توره (تیک حرکتی و صوتی شدید) — شروع ۱ تا ۲ mg\u002Fروز در دوزهای تقسیمی؛ افزایش یک روز در میان","Tourette disorder (severe motor and phonic tics) — start 1–2 mg\u002Fday in divided doses; increase every other day",{},"notCalculated",{"reason":53},{"fa":54,"en":55},"بیشتر بیماران زیر ۰٫۲ mg\u002Fkg\u002Fروز یا ۱۰ mg\u002Fروز (هر کدام کمتر)؛ بیشتر توصیه نمی‌شود. بالای ۴ mg\u002Fروز ژنوتیپ CYP2D6؛ متابولیزه‌کننده ضعیف حداکثر ۴ mg\u002Fروز و افزایش زودتر از ۱۴ روز نه. ECG پایه و دوره‌ای.","Most patients stay below 0.2 mg\u002Fkg\u002Fday or 10 mg\u002Fday (whichever is less); higher not recommended. Above 4 mg\u002Fday do CYP2D6 genotyping; poor metabolisers max 4 mg\u002Fday and no increase before 14 days. Baseline and periodic ECG.",[57],{"source":33,"section":58},"Dosage and Administration",[60],{"id":61,"severity":62,"text":63,"refs":66},"ci","block",{"fa":64,"en":65},"تیک ساده یا غیر از توره؛ داروهای ایجادکننده تیک (متیل‌فنیدیت، آمفتامین) تا قطع آن‌ها؛ QT طولانی مادرزادی، سابقه آریتمی، داروهای طولانی‌کننده QT، هیپوکالمی یا هیپومنیزیمی؛ افسردگی شدید CNS یا کما؛ حساسیت؛ ماکرولیدها و سایر مهارکننده‌های CYP3A4 (آزول‌ها، مهارکننده‌های پروتئاز).","Simple tics or tics other than Tourette; tic-causing drugs (methylphenidate, amphetamines) until withdrawn; congenital long QT, history of arrhythmia, QT-prolonging drugs, hypokalaemia or hypomagnesaemia; severe CNS depression or coma; hypersensitivity; macrolides and other CYP3A4 inhibitors (azoles, protease inhibitors).",[67],{"source":33,"section":68},"Contraindications",[70],{"text":71,"refs":74},{"fa":72,"en":73},"طولانی شدن QT و مرگ ناگهانی؛ دیسکینزی دیررس؛ NMS.","QT prolongation and sudden death; tardive dyskinesia; NMS.",[75,76],{"source":33,"section":68},{"source":33,"section":77},"Warnings",[],[],[],{"status":82,"reviewer":83,"date":83},"unverified",null,[],[86],"N05AG02",{"status":88,"forms":89,"refs":102},"registered",[90,94,98],{"code":91,"en":92,"fa":93},"01997","PIMOZIDE 2MG TAB","قرص پیموزاید ۲ میلی‌گرم",{"code":95,"en":96,"fa":97},"01009","PIMOZIDE 4MG TAB","قرص پیموزاید ۴ میلی‌گرم",{"code":99,"en":100,"fa":101},"51964","PIMOZIDE 1MG TAB","قرص پیموزاید ۱ میلی‌گرم",[103],{"source":104,"section":105,"url":106},"darooyab-generic","G-1328\u002FPimozide","https:\u002F\u002Fwww.darooyab.ir\u002FG-1328\u002FPimozide",{"kind":108,"refs":109,"id":112},"ANDA",[110],{"source":33,"section":111},"SPL approval \u002F marketing category","ANDA204521",[114,117,121,124,127],{"kind":115,"url":116,"label":112},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204521",{"kind":118,"url":119,"label":120},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=70b079e2-a1f7-4a93-8685-d60a4d7c1280","FDA Pimozide",{"kind":122,"url":123,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa686018.html",{"kind":125,"url":126,"label":86},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AG02",{"kind":128,"url":106,"label":8},"darooyab",{"pregnancy":130,"lactation":139,"pediatric":148},{"level":131,"text":132,"quote":135,"refs":136},"caution",{"fa":133,"en":134},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pimozide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[137],{"source":33,"section":138},"Pregnancy:",{"level":140,"text":141,"quote":144,"refs":145},"avoid",{"fa":142,"en":143},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for tumorigenicity and unknown cardiovascular effects in the infant, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[146],{"source":33,"section":147},"Nursing Mothers",{"level":131,"text":149,"quote":152,"refs":153},{"fa":150,"en":151},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Although Tourette's Disorder most often has its onset between the ages of 2 and 15 years, information on the use and efficacy of pimozide in patients less than 12 years of age is limited.",[154],{"source":33,"section":155},"Pediatric Use",1792191561443]