[{"data":1,"prerenderedAt":207},["ShallowReactive",2],{"drug-phytonadione":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":37,"contraindications":87,"warnings":97,"renal":107,"monitoring":108,"interactions":109,"review":110,"examples":113,"atc":125,"iran":127,"links":155,"populations":176,"usApproval":202},"phytonadione",1,{"fa":7,"en":8},"ویتامین K1 (فیتونادیون)","Phytonadione (vitamin K1)","blood",{"fa":11,"en":12},"ویتامین K","Vitamin K",[14],{"name":15,"market":16},"AquaMephyton","US",[18,19,20,21,22],"vitamin k","ویتامین کا","فیتومنادیون","کناکیون","phytomenadione",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":32,"refs":33},"syr-1","injection","im","1 mg\u002F0.5 mL prefilled syringe (neonatal)",{"amount":5,"unit":30,"perVolumeMl":31},"mg",0.5,[16],[34],{"source":35,"section":36},"fda-phytonadione","3",[38,53,70],{"id":39,"disease":40,"label":41,"population":44,"type":47,"unit":30,"dose":48,"refs":49,"durationDays":52},"neo-proph","vitamin-k-deficiency-bleeding",{"fa":42,"en":43},"پیشگیری خونریزی نوزاد — ۰٫۵ تا ۱ mg عضلانی یک بار در ساعت اول تولد","Neonatal prophylaxis — 0.5–1 mg IM once within 1 h of birth",{"maxAge":45},{"value":5,"unit":46},"month","fixed",{"perDose":31,"perDoseMax":5,"dosesPerDay":5},[50],{"source":35,"section":51},"2.3",{"min":5,"max":5},{"id":54,"disease":40,"label":55,"population":58,"type":47,"unit":30,"dose":60,"refs":61,"notes":63},"neo-tx",{"fa":56,"en":57},"درمان خونریزی نوزاد — ۱ mg زیرجلدی یا عضلانی","Neonatal treatment — 1 mg SC or IM",{"maxAge":59},{"value":5,"unit":46},{"perDose":5,"dosesPerDay":5},[62],{"source":35,"section":51},[64],{"text":65,"refs":68},{"fa":66,"en":67},"اگر مادر ضدانعقاد خوراکی می‌گرفته، دوز بالاتر در نظر گرفته شود.","Consider higher doses if the mother was on oral anticoagulants.",[69],{"source":35,"section":51},{"id":71,"disease":40,"label":72,"population":75,"type":79,"unit":30,"dose":80,"refs":84},"adult",{"fa":73,"en":74},"بزرگسال — ناشی از ضدانعقاد یا علل دیگر","Adult — anticoagulant-induced or other causes",{"minAge":76},{"value":77,"unit":78},18,"year","notCalculated",{"reason":81},{"fa":82,"en":83},"ناشی از ضدانعقاد: ۲٫۵ تا ۱۰ mg یا بیشتر (تا ۲۵ تا ۵۰ mg تک‌دوز)؛ علل دیگر: ۲٫۵ تا ۲۵ mg یا بیشتر (تا ۵۰ mg). این فرآورده ۱ mg است؛ برای بزرگسال از قدرت مناسب استفاده شود. INR پس از ۶ تا ۸ ساعت.","Anticoagulant-induced: 2.5–10 mg or more (up to 25–50 mg single dose); other causes: 2.5–25 mg or more (up to 50 mg). This product is 1 mg; use an adult strength. Check INR after 6–8 h.",[85],{"source":35,"section":86},"2.2",[88],{"id":89,"severity":90,"text":91,"refs":94},"hyper","block",{"fa":92,"en":93},"حساسیت به فیتونادیون یا اجزا.","Hypersensitivity to phytonadione or components.",[95],{"source":35,"section":96},"4",[98],{"text":99,"refs":102},{"fa":100,"en":101},"هشدار جعبه‌ای: واکنش شدید ازدیاد حساسیت و مرگ با تزریق وریدی و عضلانی؛ تا حد امکان زیرجلدی؛ وریدی حداکثر ۱ mg\u002Fmin.","Boxed warning: severe hypersensitivity reactions and fatalities with IV and IM use; give SC whenever possible; IV no faster than 1 mg\u002Fmin.",[103,105],{"source":35,"section":104},"Boxed Warning",{"source":35,"section":106},"2.1",[],[],[],{"status":111,"reviewer":112,"date":112},"unverified",null,[114,120],{"regimen":39,"formulation":25,"input":115,"expect":118},{"ageDays":116,"weightKg":117},0,3.2,{"perDose":31,"mlPerDose":119,"upperPerDose":5},0.25,{"regimen":54,"formulation":25,"input":121,"expect":124},{"ageDays":122,"weightKg":123},5,3.5,{"perDose":5,"mlPerDose":31},[126],"B02BA01",{"status":128,"forms":129,"refs":150},"registered",[130,134,138,142,146],{"code":131,"en":132,"fa":133},"01856","VITAMIN K 2MG AMP","آمپول ویتامین K ۲ میلی‌گرم",{"code":135,"en":136,"fa":137},"01003","VITAMIN K1 (PHYTOMENADIONE) 10MG\u002F1ML AMP","آمپول ویتامین K ۱ (فیتومنادیون) ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":139,"en":140,"fa":141},"01004","VITAMIN K1 (PHYTOMENADIONE) 1MG\u002F0.5ML AMP","آمپول ویتامین K ۱ (فیتومنادیون) ۱ میلی‌گرم \u002F ۰٫۵ میلی‌لیتر",{"code":143,"en":144,"fa":145},"01005","VITAMIN K1 (PHYTOMENADOINE) 10MG TAB","قرص ویتامین K ۱ (فیتومنادوین) ۱۰ میلی‌گرم",{"code":147,"en":148,"fa":149},"52467","VITAMIN K1 (PHYTOMENADIONE) TABLET, CHEWABLE ORAL 10 mg","قرص جویدنی ویتامین K ۱ (فیتومنادیون) ۱۰ میلی‌گرم",[151],{"source":152,"section":153,"url":154},"darooyab-generic","G-2954\u002FPhytonadione","https:\u002F\u002Fwww.darooyab.ir\u002FG-2954\u002FPhytonadione",[156,160,164,168,171,174],{"kind":157,"url":158,"label":159},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=215820","ANDA215820",{"kind":161,"url":162,"label":163},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=226c0a5c-3e04-65a9-01ac-e67aad9a430a","FDA Phytonadione inj.",{"kind":165,"url":166,"label":167},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682659.html","Phytonadione",{"kind":165,"url":169,"label":170},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa626026.html","Phytonadione Injection",{"kind":172,"url":173,"label":126},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B02BA01",{"kind":175,"url":154,"label":167},"darooyab",{"pregnancy":177,"lactation":186,"pediatric":194},{"level":178,"text":179,"quote":182,"refs":183},"caution",{"fa":180,"en":181},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary If Phytonadione is needed during pregnancy, consider using a preservative-free formulation .",[184],{"source":35,"section":185},"8.1",{"level":178,"text":187,"quote":190,"refs":191},{"fa":188,"en":189},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary If available, preservative-free Phytonadione is recommended when Phytonadione is needed during lactation [ Use in Specific Populations ( 8.4 )] .",[192],{"source":35,"section":193},"8.2",{"level":178,"text":195,"quote":198,"refs":199},{"fa":196,"en":197},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of Phytonadione Injectable Emulsion for prophylaxis and treatment of vitamin K deficiency have been established in neonates.",[200],{"source":35,"section":201},"8.4",{"kind":203,"refs":204,"id":159},"ANDA",[205],{"source":35,"section":206},"SPL approval \u002F marketing category",1792091066713]