[{"data":1,"prerenderedAt":170},["ShallowReactive",2],{"drug-pentoxifylline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":60,"warnings":70,"renal":71,"monitoring":72,"interactions":73,"review":74,"examples":77,"atc":83,"iran":85,"links":113,"populations":130,"usApproval":165},"pentoxifylline",1,{"fa":7,"en":8},"پنتوکسی‌فیلین","Pentoxifylline","cardiovascular",{"fa":11,"en":12},"مشتق گزانتین (بهبود جریان خون)","Xanthine derivative (haemorheologic)",[14],{"name":15,"market":16},"Trental","US",[18,19,20],"trental","ترنتال","پنتوکسی فیلین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-400","tablet","oral","400 mg extended-release tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},400,"mg",false,[16],[33],{"source":34,"section":35},"fda-pentoxifylline","How Supplied",[37],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":29,"dose":48,"refs":50,"notes":53},"std","intermittent-claudication",{"fa":41,"en":42},"لنگش متناوب — ۴۰۰ mg سه بار در روز با غذا","Intermittent claudication — 400 mg three times daily with meals",{"minAge":44},{"value":45,"unit":46},18,"year","fixed",{"perDose":28,"dosesPerDay":49},3,[51],{"source":34,"section":52},"Dosage and Administration",[54],{"text":55,"refs":58},{"fa":56,"en":57},"دست‌کم ۸ هفته ادامه. با عوارض گوارشی یا عصبی: ۴۰۰ mg دو بار. CrCl زیر ۳۰: ۴۰۰ mg یک بار در روز.","Continue at least 8 weeks. With GI or CNS effects: 400 mg twice daily. CrCl \u003C30: 400 mg once daily.",[59],{"source":34,"section":52},[61],{"id":62,"severity":63,"text":64,"refs":67},"ci","block",{"fa":65,"en":66},"خونریزی اخیر مغزی یا شبکیه؛ عدم تحمل به پنتوکسی‌فیلین یا متیل‌گزانتین‌ها (کافئین، تئوفیلین).","Recent cerebral or retinal haemorrhage; intolerance to pentoxifylline or methylxanthines (caffeine, theophylline).",[68],{"source":34,"section":69},"Contraindications",[],[],[],[],{"status":75,"reviewer":76,"date":76},"unverified",null,[78],{"regimen":38,"formulation":23,"input":79,"expect":82},{"ageYears":80,"weightKg":81},65,75,{"perDose":28,"tabletsPerDoseRounded":5},[84],"C04AD03",{"status":86,"forms":87,"refs":108},"registered",[88,92,96,100,104],{"code":89,"en":90,"fa":91},"07090","PENTOXIFYLLINE 100MG INJ","فرآورده تزریقی پنتوکسی‌فیلین ۱۰۰ میلی‌گرم",{"code":93,"en":94,"fa":95},"07137","PENTOXIFYLLINE 300MG INJ","فرآورده تزریقی پنتوکسی‌فیلین ۳۰۰ میلی‌گرم",{"code":97,"en":98,"fa":99},"00970","PENTOXIFYLLINE 400MG TAB","قرص پنتوکسی‌فیلین ۴۰۰ میلی‌گرم",{"code":101,"en":102,"fa":103},"19809","PENTOXIFYLLINE 600MG TAB","قرص پنتوکسی‌فیلین ۶۰۰ میلی‌گرم",{"code":105,"en":106,"fa":107},"18076","PHENTOXIFYLINE 400 MG  TAB.","قرص فنتوکسیفیلین ۴۰۰ میلی‌گرم .",[109],{"source":110,"section":111,"url":112},"darooyab-generic","G-1825\u002FPentoxifylline","https:\u002F\u002Fwww.darooyab.ir\u002FG-1825\u002FPentoxifylline",[114,118,122,125,128],{"kind":115,"url":116,"label":117},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=018631","NDA018631",{"kind":119,"url":120,"label":121},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2141f08f-1623-4c88-a157-8dc4aebd3bda","FDA Pentoxifylline ER",{"kind":123,"url":124,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa685027.html",{"kind":126,"url":127,"label":84},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C04AD03",{"kind":129,"url":112,"label":8},"darooyab",{"pregnancy":131,"lactation":140,"pediatric":148,"geriatric":157},{"level":132,"text":133,"quote":136,"refs":137},"caution",{"fa":134,"en":135},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","There are no adequate and well controlled studies in pregnant women. pentoxifylline extended-release tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[138],{"source":34,"section":139},"Pregnancy",{"level":132,"text":141,"quote":144,"refs":145},{"fa":142,"en":143},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Pentoxifylline and its metabolites are excreted in human milk.",[146],{"source":34,"section":147},"Nursing Mothers",{"level":149,"text":150,"quote":153,"refs":154},"not-established",{"fa":151,"en":152},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[155],{"source":34,"section":156},"Pediatric Use",{"level":132,"text":158,"quote":161,"refs":162},{"fa":159,"en":160},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[163],{"source":34,"section":164},"Geriatric Use",{"kind":166,"refs":167,"id":117},"NDA authorized generic",[168],{"source":34,"section":169},"SPL approval \u002F marketing category",1792111464009]