[{"data":1,"prerenderedAt":132},["ShallowReactive",2],{"drug-nitroglycerin-ointment":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":54,"warnings":64,"renal":65,"monitoring":66,"interactions":67,"review":75,"examples":78,"atc":79,"iran":81,"usApproval":88,"links":94,"populations":105},"nitroglycerin-ointment",1,{"fa":7,"en":8},"پماد نیتروگلیسرین ۰٫۴٪ (شقاق مقعد)","Nitroglycerin 0.4% ointment (anal fissure)","cardiovascular",{"fa":11,"en":12},"نیترات موضعی","Topical nitrate",[14],{"name":15,"market":16},"Rectiv","US",[18,19,20],"rectiv","رکتیو","پماد نیتروگلیسرین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"oint","ointment","rectal","0.4% ointment (1 inch = 1.5 mg nitroglycerin)",{"amount":5,"unit":28,"perUnit":28},"application",[16],[31],{"source":32,"section":33},"fda-rectiv","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":46,"dose":47,"refs":51},"fissure","anal-fissure",{"fa":39,"en":40},"درد شقاق مزمن مقعد — ۱ اینچ (۱٫۵ mg) داخل مقعد هر ۱۲ ساعت تا ۳ هفته","Chronic anal fissure pain — 1 inch (1.5 mg) intra-anally every 12 h up to 3 weeks",{"minAge":42},{"value":43,"unit":44},18,"year","notCalculated","mg",{"reason":48},{"fa":49,"en":50},"با انگشت پوشیده (دستکش یا کاور)، به اندازه خط ۱ اینچی روی جعبه (۳۷۵ mg پماد = ۱٫۵ mg نیتروگلیسرین) آرام داخل مجرای مقعد؛ هر ۱۲ ساعت، حداکثر ۳ هفته.","With a covered finger, a 1-inch line as marked on the carton (375 mg ointment = 1.5 mg nitroglycerin) gently into the anal canal; every 12 h for up to 3 weeks.",[52],{"source":32,"section":53},"2",[55],{"id":56,"severity":57,"text":58,"refs":61},"ci","block",{"fa":59,"en":60},"مصرف مهارکننده‌های PDE5 (سیلدنافیل، تادالافیل، واردنافیل)؛ کم‌خونی شدید؛ افزایش فشار داخل جمجمه؛ حساسیت به نیترات‌ها.","PDE5 inhibitors (sildenafil, tadalafil, vardenafil); severe anaemia; raised intracranial pressure; nitrate hypersensitivity.",[62],{"source":32,"section":63},"4",[],[],[],[68],{"with":69,"text":70,"refs":73},"pde5",{"fa":71,"en":72},"سیلدنافیل، تادالافیل و واردنافیل: افت شدید فشار — ممنوع.","Sildenafil, tadalafil and vardenafil: severe hypotension — contraindicated.",[74],{"source":32,"section":63},{"status":76,"reviewer":77,"date":77},"unverified",null,[],[80],"C05AE01",{"status":82,"refs":83},"not-found",[84],{"source":85,"section":86,"url":87},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Nitroglycerin%200.4%25%20ointment",{"kind":89,"refs":90,"id":93},"NDA",[91],{"source":32,"section":92},"SPL approval \u002F marketing category","NDA021359",[95,98,102],{"kind":96,"url":97,"label":93},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021359",{"kind":99,"url":100,"label":101},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=603aa9ed-54c4-4a35-ade4-690fa44850e4","FDA Rectiv",{"kind":103,"url":104,"label":80},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C05AE01",{"pregnancy":106,"pediatric":115,"geriatric":124},{"level":107,"text":108,"quote":111,"refs":112},"caution",{"fa":109,"en":110},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no data on the use of nitroglycerin ointment intra-anally during pregnancy to determine a drug-associated risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes.",[113],{"source":32,"section":114},"8.1",{"level":116,"text":117,"quote":120,"refs":121},"not-established",{"fa":118,"en":119},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of RECTIV in pediatric patients under 18 years of age have not been established.",[122],{"source":32,"section":123},"8.4",{"level":107,"text":125,"quote":128,"refs":129},{"fa":126,"en":127},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of RECTIV did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.",[130],{"source":32,"section":131},"8.5",1792115190362]