[{"data":1,"prerenderedAt":161},["ShallowReactive",2],{"drug-nefazodone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":18,"regimens":42,"contraindications":66,"warnings":76,"renal":84,"monitoring":85,"interactions":86,"review":87,"examples":90,"atc":96,"iran":98,"links":105,"populations":122,"usApproval":156},"nefazodone",1,{"fa":7,"en":8},"نفازودون","Nefazodone","nervous-system",{"fa":11,"en":12},"ضدافسردگی فنیل‌پیپرازین","Phenylpiperazine antidepressant",[14],{"name":8,"market":15},"US",[17,7],"serzone",[19,33],{"id":20,"form":21,"route":22,"label":23,"concentration":24,"markets":28,"refs":29},"tab-100","tablet","oral","100 mg tablet (scored)",{"amount":25,"unit":26,"perUnit":21,"scored":27},100,"mg",true,[15],[30],{"source":31,"section":32},"fda-nefazodone","How Supplied",{"id":34,"form":21,"route":22,"label":35,"concentration":36,"markets":39,"refs":40},"tab-50","50 mg tablet",{"amount":37,"unit":26,"perUnit":21,"scored":38},50,false,[15],[41],{"source":31,"section":32},[43],{"id":44,"disease":44,"label":45,"population":48,"type":52,"unit":26,"dose":53,"refs":56,"notes":59},"mdd",{"fa":46,"en":47},"افسردگی اساسی بزرگسال — شروع ۱۰۰ mg دو بار در روز؛ محدوده مؤثر ۳۰۰ تا ۶۰۰ mg\u002Fروز","Major depressive disorder, adults — start 100 mg twice daily; effective range 300–600 mg\u002Fday",{"minAge":49},{"value":50,"unit":51},18,"year","fixed",{"perDose":25,"perDoseMax":54,"dosesPerDay":55},300,2,[57],{"source":31,"section":58},"Dosage and Administration",[60],{"text":61,"refs":64},{"fa":62,"en":63},"افزایش ۱۰۰ تا ۲۰۰ mg\u002Fروز با فاصله دست‌کم ۱ هفته. سالمند یا ناتوان: شروع ۵۰ mg دو بار. خطر نارسایی کبد در انتخاب دارو لحاظ شود.","Increase by 100–200 mg\u002Fday at intervals of at least 1 week. Elderly or debilitated: start 50 mg twice daily. Weigh hepatic failure risk when choosing.",[65],{"source":31,"section":58},[67],{"id":68,"severity":69,"text":70,"refs":73},"ci","block",{"fa":71,"en":72},"ترفنادین، آستمیزول، سیزاپراید، پیموزاید یا کاربامازپین همزمان؛ سابقه قطع نفازودون به‌دلیل آسیب کبدی؛ حساسیت به نفازودون یا ضدافسردگی‌های فنیل‌پیپرازین. تریازولام در بیشتر بیماران پرهیز شود.","Concomitant terfenadine, astemizole, cisapride, pimozide or carbamazepine; prior withdrawal from nefazodone for liver injury; hypersensitivity to nefazodone or phenylpiperazine antidepressants. Avoid triazolam in most patients.",[74],{"source":31,"section":75},"Contraindications",[77],{"text":78,"refs":81},{"fa":79,"en":80},"هشدار جعبه‌ای: نارسایی کبد تهدیدکننده حیات (حدود ۱ مورد مرگ یا پیوند در ۲۵۰ تا ۳۰۰ هزار بیمار-سال)؛ خودکشی در کودکان و جوانان.","Boxed warning: life-threatening hepatic failure (about 1 death or transplant per 250,000–300,000 patient-years); suicidality in children and young adults.",[82],{"source":31,"section":83},"Boxed Warning",[],[],[],{"status":88,"reviewer":89,"date":89},"unverified",null,[91],{"regimen":44,"formulation":20,"input":92,"expect":95},{"ageYears":93,"weightKg":94},40,70,{"perDose":25,"tabletsPerDoseRounded":5,"upperPerDose":54},[97],"N06AX06",{"status":99,"refs":100},"not-found",[101],{"source":102,"section":103,"url":104},"darooyab-generic","G-599\u002FNefazodone","https:\u002F\u002Fwww.darooyab.ir\u002FG-599\u002FNefazodone",[106,110,114,117,120],{"kind":107,"url":108,"label":109},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=076037","ANDA076037",{"kind":111,"url":112,"label":113},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=51ff7db5-aaf9-4c3c-86e6-958ebf16b60f","FDA Nefazodone",{"kind":115,"url":116,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695005.html",{"kind":118,"url":119,"label":97},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AX06",{"kind":121,"url":104,"label":8},"darooyab",{"pregnancy":123,"lactation":132,"pediatric":140,"geriatric":148},{"level":124,"text":125,"quote":128,"refs":129},"caution",{"fa":126,"en":127},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy.",[130],{"source":31,"section":131},"Pregnancy",{"level":124,"text":133,"quote":136,"refs":137},{"fa":134,"en":135},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when nefazodone is administered to a nursing woman.",[138],{"source":31,"section":139},"Nursing Mothers",{"level":141,"text":142,"quote":145,"refs":146},"avoid",{"fa":143,"en":144},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Nefazodone hydrochloride tablets are not approved for use in pediatric patients (see WARNINGS, Clinical Worsening and Suicide Risk ;",[147],{"source":31,"section":83},{"level":124,"text":149,"quote":152,"refs":153},{"fa":150,"en":151},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The usual precautions should be observed in elderly patients who have concomitant medical illnesses or who are receiving concomitant drugs.",[154],{"source":31,"section":155},"Geriatric Use",{"kind":157,"refs":158,"id":109},"ANDA",[159],{"source":31,"section":160},"SPL approval \u002F marketing category",1792191557000]