[{"data":1,"prerenderedAt":249},["ShallowReactive",2],{"drug-mycophenolate":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":38,"contraindications":104,"warnings":114,"renal":122,"monitoring":123,"interactions":124,"review":125,"examples":128,"atc":146,"iran":148,"usApproval":180,"links":186,"populations":207},"mycophenolate",1,{"fa":7,"en":8},"مایکوفنولات موفتیل","Mycophenolate mofetil","antineoplastic-immunomodulating",{"fa":11,"en":12},"سرکوب‌کننده ایمنی (آنتی‌متابولیت)","Immunosuppressant (antimetabolite)",[14],{"name":15,"market":16},"CellCept","US",[18,19,20,21,22],"cellcept","سل سپت","MMF","مایکوفنولات","cellmune",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"cap-250","capsule","oral","250 mg capsule",{"amount":30,"unit":31,"perUnit":26,"scored":32},250,"mg",false,[16],[35],{"source":36,"section":37},"fda-mycophenolate","3",[39,64,78],{"id":40,"disease":41,"label":42,"population":45,"type":49,"unit":31,"dose":50,"refs":53,"notes":56},"kidney","transplant-rejection",{"fa":43,"en":44},"پیوند کلیه — بزرگسال ۱ g دو بار در روز","Kidney transplant — adult 1 g twice daily",{"minAge":46},{"value":47,"unit":48},18,"year","fixed",{"perDose":51,"dosesPerDay":52},1000,2,[54],{"source":36,"section":55},"2.2",[57],{"text":58,"refs":61},{"fa":59,"en":60},"همراه سیکلوسپورین یا تاکرولیموس و کورتون. GFR زیر ۲۵ در کلیه پیوندی: بیش از ۱ g دو بار در روز نه. ANC زیر ۱۳۰۰: قطع یا کاهش.","With cyclosporine or tacrolimus and steroids. Graft GFR \u003C25: no more than 1 g twice daily. ANC \u003C1300: interrupt or reduce.",[62],{"source":36,"section":63},"2.5",{"id":65,"disease":41,"label":66,"population":69,"type":49,"unit":31,"dose":71,"refs":73},"heart",{"fa":67,"en":68},"پیوند قلب یا کبد — بزرگسال ۱٫۵ g دو بار در روز","Heart or liver transplant — adult 1.5 g twice daily",{"minAge":70},{"value":47,"unit":48},{"perDose":72,"dosesPerDay":52},1500,[74,76],{"source":36,"section":75},"2.3",{"source":36,"section":77},"2.4",{"id":79,"disease":41,"label":80,"population":83,"type":88,"unit":31,"dose":89,"refs":91,"limits":93,"notes":97},"child",{"fa":81,"en":82},"پیوند کلیه کودک (۳ ماه به بالا) — ۶۰۰ mg\u002Fm² دو بار در روز (حداکثر ۲ g\u002Fروز)","Pediatric kidney transplant (≥3 months) — 600 mg\u002Fm² twice daily (max 2 g\u002Fday)",{"minAge":84,"maxAge":87},{"value":85,"unit":86},3,"month",{"value":47,"unit":48},"bsa",{"perM2PerDay":90,"dividedDoses":52},1200,[92],{"source":36,"section":55},{"maxPerDay":94,"refs":95},2000,[96],{"source":36,"section":55},[98],{"text":99,"refs":102},{"fa":100,"en":101},"کودک معمولاً سوسپانسیون CellCept؛ کپسول برای کودکی که قادر به بلع باشد.","Children usually receive CellCept oral suspension; capsules if able to swallow.",[103],{"source":36,"section":55},[105],{"id":106,"severity":107,"text":108,"refs":111},"hyper","block",{"fa":109,"en":110},"حساسیت به مایکوفنولات یا مایکوفنولیک اسید.","Hypersensitivity to mycophenolate mofetil or mycophenolic acid.",[112],{"source":36,"section":113},"4",[115],{"text":116,"refs":119},{"fa":117,"en":118},"هشدار جعبه‌ای: سقط و ناهنجاری جنینی (پیشگیری از بارداری لازم)، لنفوم و بدخیمی پوست، عفونت جدی.","Boxed warning: first-trimester loss and congenital malformations (contraception required), lymphoma and skin malignancy, serious infections.",[120],{"source":36,"section":121},"Boxed Warning",[],[],[],{"status":126,"reviewer":127,"date":127},"unverified",null,[129,135,139],{"regimen":40,"formulation":25,"input":130,"expect":133},{"ageYears":131,"weightKg":132},45,70,{"perDose":51,"tabletsPerDoseRounded":134},4,{"regimen":65,"formulation":25,"input":136,"expect":137},{"ageYears":131,"weightKg":132},{"perDose":72,"tabletsPerDoseRounded":138},6,{"regimen":79,"formulation":25,"input":140,"expect":144},{"ageYears":141,"weightKg":142,"heightCm":143},12,37.5,150,{"perDose":145,"tabletsPerDoseRounded":85},750,[147],"L04AA06",{"status":149,"forms":150,"refs":175},"registered",[151,155,159,163,167,171],{"code":152,"en":153,"fa":154},"01755","MYCOPHENOLATE MOFETIL 250MG CAP","کپسول مایکوفنولات موفتیل ۲۵۰ میلی‌گرم",{"code":156,"en":157,"fa":158},"01752","MYCOPHENOLATE MOFETIL 250MG TAB","قرص مایکوفنولات موفتیل ۲۵۰ میلی‌گرم",{"code":160,"en":161,"fa":162},"01753","MYCOPHENOLATE MOFETIL 500MG TAB","قرص مایکوفنولات موفتیل ۵۰۰ میلی‌گرم",{"code":164,"en":165,"fa":166},"11606","MYCOPHENOLATE SODIUM 180MG TAB","قرص مایکوفنولات سدیم ۱۸۰ میلی‌گرم",{"code":168,"en":169,"fa":170},"11607","MYCOPHENOLATE SODIUM 360MG TAB","قرص مایکوفنولات سدیم ۳۶۰ میلی‌گرم",{"code":172,"en":173,"fa":174},"50710","MYCOPHENOLATE MOFETIL POWDER, FOR SUSPENSION ORAL 1 g\u002F5mL 110 g","سوسپانسیون خوراکی مایکوفنولات موفتیل ۱ گرم \u002F ۵ میلی‌لیتر ۱۱۰ گرم",[176],{"source":177,"section":178,"url":179},"darooyab-generic","G-2741\u002FMycophenolate-Mofetil","https:\u002F\u002Fwww.darooyab.ir\u002FG-2741\u002FMycophenolate-Mofetil",{"kind":181,"refs":182,"id":185},"ANDA",[183],{"source":36,"section":184},"SPL approval \u002F marketing category","ANDA217828",[187,190,194,198,201,204],{"kind":188,"url":189,"label":185},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=217828",{"kind":191,"url":192,"label":193},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3eb584dc-f72d-4545-96fa-ab3d47be41ce","FDA Mycophenolate",{"kind":195,"url":196,"label":197},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601081.html","Mycophenolate",{"kind":195,"url":199,"label":200},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa622068.html","Mycophenolate Injection",{"kind":202,"url":203,"label":147},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L04AA06",{"kind":205,"url":179,"label":206},"darooyab","Mycophenolate-Mofetil",{"pregnancy":208,"lactation":216,"pediatric":225,"geriatric":233,"reproductive":241},{"level":209,"text":210,"quote":213,"refs":214},"avoid",{"fa":211,"en":212},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","WARNING: EMBRYOFETAL TOXICITY, MALIGNANCIES and SERIOUS INFECTIONS See full prescribing information for complete boxed warning Use during pregnancy is associated with increased risks of first trimester pregnancy loss and congenital malformations.",[215],{"source":36,"section":121},{"level":217,"text":218,"quote":221,"refs":222},"caution",{"fa":219,"en":220},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of mycophenolate in human milk, or the effects on milk production.",[223],{"source":36,"section":224},"8.2",{"level":217,"text":226,"quote":229,"refs":230},{"fa":227,"en":228},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness have been established in pediatric patients 3 months and older for the prophylaxis of organ rejection of allogenic kidney, heart or liver transplants.",[231],{"source":36,"section":232},"8.4",{"level":217,"text":234,"quote":237,"refs":238},{"fa":235,"en":236},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for a geriatric patient should take into consideration the presence of decreased hepatic, renal or cardiac function and of concomitant drug therapies [see Adverse Reactions (6.1) , Drug Interactions (7) ].",[239],{"source":36,"section":240},"8.5",{"level":217,"text":242,"quote":245,"refs":246},{"fa":243,"en":244},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Female Patients Females of reproductive potential taking mycophenolate mofetil must receive contraceptive counseling and use acceptable contraception (see Table 9 for acceptable contraception methods).",[247],{"source":36,"section":248},"8.3",1792156188298]