[{"data":1,"prerenderedAt":187},["ShallowReactive",2],{"drug-milrinone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":85,"warnings":95,"renal":102,"monitoring":103,"interactions":104,"review":105,"examples":108,"atc":123,"iran":125,"usApproval":137,"links":143,"populations":160},"milrinone",1,{"fa":7,"en":8},"میلرینون","Milrinone","cardiovascular",{"fa":11,"en":12},"مهارکننده فسفودی‌استراز ۳ (اینوتروپ)","PDE3 inhibitor (inotrope)",[14],{"name":15,"market":16},"Primacor","US",[18,7,19],"primacor","میلرینون لاکتات",[21,34],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"dil-200","injection","iv","Diluted to 200 mcg\u002FmL (per label table)",{"amount":27,"unit":28,"perVolumeMl":5},200,"mcg",[16],[31],{"source":32,"section":33},"fda-milrinone","Dosage and Administration",{"id":35,"form":23,"route":24,"label":36,"concentration":37,"markets":39,"refs":40},"vial-1","1 mg\u002FmL vial (= 1000 mcg\u002FmL, for loading)",{"amount":38,"unit":28,"perVolumeMl":5},1000,[16],[41],{"source":32,"section":42},"How Supplied",[44,62],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":58,"durationDays":60,"allowedFormulations":61},"load","heart-failure",{"fa":48,"en":49},"نارسایی حاد قلب — دوز بارگذاری ۵۰ mcg\u002Fkg آهسته در ۱۰ دقیقه","Acute decompensated heart failure — loading 50 mcg\u002Fkg slowly over 10 min",{"minAge":51},{"value":52,"unit":53},18,"year","weightBased",{"perKgPerDose":56,"intervalHours":57},50,24,[59],{"source":32,"section":33},{"min":5,"max":5},[35],{"id":63,"disease":46,"label":64,"population":67,"type":69,"unit":28,"dose":70,"refs":73,"allowedFormulations":75,"notes":76},"maint",{"fa":65,"en":66},"نگهدارنده — ۰٫۳۷۵ تا ۰٫۷۵ mcg\u002Fkg\u002Fدقیقه (استاندارد ۰٫۵)","Maintenance — 0.375–0.75 mcg\u002Fkg\u002Fmin (standard 0.5)",{"minAge":68},{"value":52,"unit":53},"infusion",{"perKgPerMin":71,"perKgPerMinMax":72},0.375,0.75,[74],{"source":32,"section":33},[22],[77],{"text":78,"refs":81},{"fa":79,"en":80},"بیش از ۴۸ ساعت ایمنی یا اثر ثابت نشده. نارسایی کلیه: کاهش سرعت طبق جدول برچسب.","Not shown safe or effective beyond 48 h. Renal impairment: reduce rate per label table.",[82,84],{"source":32,"section":83},"Warnings",{"source":32,"section":33},[86],{"id":87,"severity":88,"text":89,"refs":92},"hyper","block",{"fa":90,"en":91},"حساسیت به میلرینون.","Hypersensitivity to milrinone.",[93],{"source":32,"section":94},"Contraindications",[96],{"text":97,"refs":100},{"fa":98,"en":99},"آریتمی بطنی و فوق‌بطنی؛ افت فشار؛ مصرف طولانی خوراکی در نارسایی شدید مرگ بیشتر.","Ventricular and supraventricular arrhythmias; hypotension; long-term oral use in severe HF increased mortality.",[101],{"source":32,"section":83},[],[],[],{"status":106,"reviewer":107,"date":107},"unverified",null,[109,116],{"regimen":45,"formulation":35,"input":110,"expect":113},{"ageYears":111,"weightKg":112},60,70,{"perDose":114,"mlPerDose":115},3500,3.5,{"regimen":63,"formulation":22,"input":117,"expect":118},{"ageYears":111,"weightKg":112},{"perMin":119,"mlPerHour":120,"upperPerMin":121,"upperMlPerHour":122},26.25,7.88,52.5,15.75,[124],"C01CE02",{"status":126,"forms":127,"refs":132},"registered",[128],{"code":129,"en":130,"fa":131},"01877","MILRINONE LACTATE 10MG\u002F10ML INJ","فرآورده تزریقی میلرینون لاکتات ۱۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",[133],{"source":134,"section":135,"url":136},"darooyab-generic","G-1772\u002FMilrinone","https:\u002F\u002Fwww.darooyab.ir\u002FG-1772\u002FMilrinone",{"kind":138,"refs":139,"id":142},"ANDA",[140],{"source":32,"section":141},"SPL approval \u002F marketing category","ANDA216373",[144,147,151,155,158],{"kind":145,"url":146,"label":142},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=216373",{"kind":148,"url":149,"label":150},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=07dddead-22ed-004c-e063-6294a90a76fc","FDA Milrinone",{"kind":152,"url":153,"label":154},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa626002.html","Milrinone Injection",{"kind":156,"url":157,"label":124},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C01CE02",{"kind":159,"url":136,"label":8},"darooyab",{"pregnancy":161,"lactation":170,"pediatric":178},{"level":162,"text":163,"quote":166,"refs":167},"caution",{"fa":164,"en":165},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Milrinone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[168],{"source":32,"section":169},"Pregnancy",{"level":162,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","",[176],{"source":32,"section":177},"Nursing Mothers",{"level":179,"text":180,"quote":183,"refs":184},"not-established",{"fa":181,"en":182},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[185],{"source":32,"section":186},"Pediatric Use",1792191555682]