[{"data":1,"prerenderedAt":191},["ShallowReactive",2],{"drug-midazolam-nasal":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":37,"contraindications":64,"warnings":84,"renal":92,"monitoring":93,"interactions":94,"review":95,"examples":98,"atc":104,"iran":106,"links":134,"populations":153,"usApproval":186},"midazolam-nasal",1,{"fa":7,"en":8},"میدازولام اسپری بینی","Midazolam nasal spray","nervous-system",{"fa":11,"en":12},"بنزودیازپین (ضدتشنج اورژانسی)","Benzodiazepine (rescue anticonvulsant)",[14],{"name":15,"market":16},"Nayzilam","US",[18,19,20,21],"nayzilam","midazolam","میدازولام","اسپری تشنج",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"spray-5","nasal-spray","nasal","5 mg\u002F0.1 mL single-dose nasal spray",{"amount":29,"unit":30,"perUnit":31},5,"mg","spray",[16],[34],{"source":35,"section":36},"fda-nayzilam","3",[38],{"id":39,"disease":40,"label":41,"population":44,"type":48,"unit":30,"dose":49,"refs":50,"limits":53,"notes":57},"cluster","status-epilepticus",{"fa":42,"en":43},"تشنج خوشه‌ای — ۱۲ سال به بالا: یک پاف ۵ mg در یک سوراخ بینی","Seizure cluster — ≥12 y: one 5 mg spray in one nostril",{"minAge":45},{"value":46,"unit":47},12,"year","fixed",{"perDose":29,"dosesPerDay":5},[51],{"source":35,"section":52},"2.2",{"maxPerDay":54,"refs":55},10,[56],{"source":35,"section":52},[58],{"text":59,"refs":62},{"fa":60,"en":61},"اگر پس از ۱۰ دقیقه پاسخ نبود، یک پاف دیگر در سوراخ دیگر. بیش از ۲ دوز برای یک حمله نه؛ حداکثر یک حمله هر ۳ روز و ۵ حمله در ماه.","If no response after 10 min, one more spray in the other nostril. No more than 2 doses per cluster; no more than one cluster every 3 days and 5 per month.",[63],{"source":35,"section":52},[65,74],{"id":66,"severity":67,"text":68,"refs":71},"hyper","block",{"fa":69,"en":70},"حساسیت به میدازولام؛ گلوکوم زاویه بسته حاد.","Hypersensitivity to midazolam; acute narrow-angle glaucoma.",[72],{"source":35,"section":73},"4",{"id":75,"severity":67,"rule":76,"text":78,"refs":81},"lt12",{"maxAge":77},{"value":46,"unit":47},{"fa":79,"en":80},"زیر ۱۲ سال در برچسب نیست.","Not labelled under 12 years.",[82],{"source":35,"section":83},"8.4",[85],{"text":86,"refs":89},{"fa":87,"en":88},"هشدار جعبه‌ای: با اپیوئیدها دپرسیون تنفسی و مرگ؛ سوءمصرف و وابستگی.","Boxed warning: with opioids respiratory depression and death; abuse and dependence.",[90],{"source":35,"section":91},"Boxed Warning",[],[],[],{"status":96,"reviewer":97,"date":97},"unverified",null,[99],{"regimen":39,"formulation":24,"input":100,"expect":103},{"ageYears":101,"weightKg":102},20,60,{"perDose":29},[105],"N05CD08",{"status":107,"forms":108,"refs":129},"registered",[109,113,117,121,125],{"code":110,"en":111,"fa":112},"17001","MIDAZOLAM 2.5MG\u002FML 100ML SYRUP","شربت میدازولام ۲٫۵ میلی‌گرم \u002F میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":114,"en":115,"fa":116},"01591","MIDAZOLAM HCL 15MG\u002F3ML AMP","آمپول میدازولام هیدروکلراید ۱۵ میلی‌گرم \u002F ۳ میلی‌لیتر",{"code":118,"en":119,"fa":120},"02010","MIDAZOLAM HCL 2MG\u002FML SYRUP","شربت میدازولام هیدروکلراید ۲ میلی‌گرم \u002F میلی‌لیتر",{"code":122,"en":123,"fa":124},"00852","MIDAZOLAM HCL 5MG\u002F1ML AMP","آمپول میدازولام هیدروکلراید ۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":126,"en":127,"fa":128},"17231","MIDAZOLAM MALEATE 50MG\u002F5ML BUCCAL LIQUID","مایع میدازولام مالئات ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر بوککال",[130],{"source":131,"section":132,"url":133},"darooyab-generic","G-1307\u002FMidazolam","https:\u002F\u002Fwww.darooyab.ir\u002FG-1307\u002FMidazolam",[135,139,143,147,150],{"kind":136,"url":137,"label":138},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=211321","NDA211321",{"kind":140,"url":141,"label":142},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2b29422e-54d5-4a49-8522-e9cf752368c3","FDA Nayzilam",{"kind":144,"url":145,"label":146},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa621044.html","Midazolam Nasal Spray",{"kind":148,"url":149,"label":105},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05CD08",{"kind":151,"url":133,"label":152},"darooyab","Midazolam",{"pregnancy":154,"lactation":163,"pediatric":171,"geriatric":178},{"level":155,"text":156,"quote":159,"refs":160},"caution",{"fa":157,"en":158},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and\u002For neonatal withdrawal [see Warnings and Precautions (5.9) and Clinical Considerations ].",[161],{"source":35,"section":162},"8.1",{"level":155,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Midazolam is excreted in human milk.",[169],{"source":35,"section":170},"8.2",{"level":155,"text":172,"quote":175,"refs":176},{"fa":173,"en":174},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness in pediatric patients below the age of 12 years have not been established.",[177],{"source":35,"section":83},{"level":155,"text":179,"quote":182,"refs":183},{"fa":180,"en":181},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","… ciated with rare reports of death under circumstances compatible with cardiorespiratory depression [see Warnings and Precautions (5.4) ].",[184],{"source":35,"section":185},"8.5",{"kind":187,"refs":188,"id":138},"NDA",[189],{"source":35,"section":190},"SPL approval \u002F marketing category",1792091064596]