[{"data":1,"prerenderedAt":175},["ShallowReactive",2],{"drug-methylene-blue":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":60,"warnings":70,"renal":78,"monitoring":79,"interactions":80,"review":88,"examples":91,"atc":98,"iran":100,"links":120,"populations":135,"usApproval":170},"methylene-blue",1,{"fa":7,"en":8},"متیلن بلو (تزریقی)","Methylene blue (injection)","various",{"fa":11,"en":12},"پادزهر مت‌هموگلوبینمی","Methaemoglobinaemia antidote",[14],{"name":15,"market":16},"ProvayBlue","US",[18,19,20],"provayblue","متیلن بلو","آبی متیلن",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"amp-5","injection","iv","5 mg\u002FmL (10 mg\u002F2 mL; 50 mg\u002F10 mL)",{"amount":28,"unit":29,"perVolumeMl":5},5,"mg",[16],[32],{"source":33,"section":34},"fda-provayblue","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":43,"unit":29,"dose":44,"refs":45,"durationDays":48,"notes":49},"std","methemoglobinemia",{"fa":40,"en":41},"مت‌هموگلوبینمی اکتسابی — ۱ mg\u002Fkg وریدی در ۵ تا ۳۰ دقیقه","Acquired methaemoglobinaemia — 1 mg\u002Fkg IV over 5–30 min",{},"weightBased",{"perKgPerDay":5,"dividedDoses":5},[46],{"source":33,"section":47},"2.1",{"min":5,"max":5},[50],{"text":51,"refs":54},{"fa":52,"en":53},"اگر مت‌هموگلوبین بالای ۳۰٪ ماند یا علائم ادامه یافت، ۱ mg\u002Fkg دیگر پس از ۱ ساعت؛ پس از ۲ دوز درمان دیگر. نارسایی متوسط تا شدید کلیه: فقط یک دوز. با D5W رقیق شود نه سالین؛ زیرجلدی نه.","If methaemoglobin stays >30% or symptoms persist, one more 1 mg\u002Fkg after 1 h; after 2 doses use other treatment. Moderate–severe renal impairment: single dose only. Dilute in D5W, not saline; never subcutaneous.",[55,56,58],{"source":33,"section":47},{"source":33,"section":57},"2.2",{"source":33,"section":59},"2.3",[61],{"id":62,"severity":63,"text":64,"refs":67},"ci","block",{"fa":65,"en":66},"حساسیت شدید به متیلن بلو یا رنگ‌های تیازینی؛ کمبود G6PD (همولیز).","Severe hypersensitivity to methylene blue or thiazine dyes; G6PD deficiency (haemolysis).",[68],{"source":33,"section":69},"4",[71],{"text":72,"refs":75},{"fa":73,"en":74},"هشدار جعبه‌ای: سندرم سروتونین با SSRI، SNRI، MAOI و اپیوئیدها — همزمان مصرف نشود.","Boxed warning: serotonin syndrome with SSRIs, SNRIs, MAOIs and opioids — avoid concomitant use.",[76],{"source":33,"section":77},"Boxed Warning",[],[],[81],{"with":82,"text":83,"refs":86},"serotonergic",{"fa":84,"en":85},"SSRI، SNRI، MAOI و اپیوئیدها: سندرم سروتونین جدی یا کشنده.","SSRIs, SNRIs, MAOIs and opioids: serious or fatal serotonin syndrome.",[87],{"source":33,"section":77},{"status":89,"reviewer":90,"date":90},"unverified",null,[92],{"regimen":37,"formulation":23,"input":93,"expect":96},{"ageYears":94,"weightKg":95},40,70,{"perDose":95,"mlPerDose":97},14,[99],"V03AB17",{"status":101,"forms":102,"refs":115},"registered",[103,107,111],{"code":104,"en":105,"fa":106},"01589","METHYLENE BLUE 100MG\u002F10ML AMP","آمپول متیلن بلو ۱۰۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":108,"en":109,"fa":110},"05979","METHYLENE BLUE 50MG\u002F5ML AMP","آمپول متیلن بلو ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":112,"en":113,"fa":114},"51920","METHYLENE BLUE INJECTION PARENTERAL 10 mg\u002F1mL 1 mL","فرآورده تزریقی متیلن بلو ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۱ میلی‌لیتر",[116],{"source":117,"section":118,"url":119},"darooyab-generic","G-1965\u002FMethylene-Blue","https:\u002F\u002Fwww.darooyab.ir\u002FG-1965\u002FMethylene-Blue",[121,125,129,132],{"kind":122,"url":123,"label":124},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204630","NDA204630",{"kind":126,"url":127,"label":128},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4f6848e5-35ed-4046-b13c-3032b5ba3232","FDA ProvayBlue",{"kind":130,"url":131,"label":99},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB17",{"kind":133,"url":119,"label":134},"darooyab","Methylene-Blue",{"pregnancy":136,"lactation":145,"pediatric":154,"geriatric":162},{"level":137,"text":138,"quote":141,"refs":142},"avoid",{"fa":139,"en":140},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary PROVAYBLUE may cause fetal harm when administered to a pregnant woman.",[143],{"source":33,"section":144},"8.1",{"level":146,"text":147,"quote":150,"refs":151},"caution",{"fa":148,"en":149},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information regarding the presence of methylene blue in human milk, the effects on the breastfed infant, or the effects on milk production.",[152],{"source":33,"section":153},"8.2",{"level":146,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of PROVAYBLUE for the treatment of acquired methemoglobinemia have been established in pediatric patients.",[160],{"source":33,"section":161},"8.4",{"level":146,"text":163,"quote":166,"refs":167},{"fa":164,"en":165},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of PROVAYBLUE did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.",[168],{"source":33,"section":169},"8.5",{"kind":171,"refs":172,"id":124},"NDA",[173],{"source":33,"section":174},"SPL approval \u002F marketing category",1792108430372]