[{"data":1,"prerenderedAt":227},["ShallowReactive",2],{"drug-methadone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":58,"warnings":68,"renal":78,"monitoring":79,"interactions":80,"review":81,"examples":84,"atc":85,"iran":87,"usApproval":159,"links":165,"populations":184},"methadone",1,{"fa":7,"en":8},"متادون","Methadone","nervous-system",{"fa":11,"en":12},"آگونیست اپیوئید (درمان نگهدارنده اعتیاد)","Opioid agonist (OUD maintenance)",[14],{"name":15,"market":16},"Diskets","US",[18,19,7,20],"diskets","dolophine","شربت متادون",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"disp-40","tablet","oral","40 mg dispersible tablet (quadrisected; disperse in ~120 mL liquid)",{"amount":28,"unit":29,"perUnit":24},40,"mg",[16],[32],{"source":33,"section":34},"fda-methadone","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":51},"induction","opioid-use-disorder",{"fa":40,"en":41},"القای درمان اعتیاد — ۲۰ تا ۳۰ mg دوز اول (حداکثر ۳۰ mg)","OUD induction — first dose 20–30 mg (max 30 mg)",{"minAge":43},{"value":44,"unit":45},18,"year","notCalculated",{"reason":48},{"fa":49,"en":50},"فقط در مراکز مجاز درمان اعتیاد. دوز اول ۲۰ تا ۳۰ mg تحت نظر، وقتی بیمار علائم ترک دارد و خواب‌آلود نیست؛ دوز اول بیش از ۳۰ mg نشود. اگر پس از ۲ تا ۴ ساعت علائم ترک ماند، ۵ تا ۱۰ mg دیگر. تنظیم‌های بعدی طبق برچسب. قرص در آب یا آب‌میوه حل شود؛ هرگز تزریق نشود.","Only in certified opioid treatment programmes. First dose 20–30 mg supervised, when the patient shows withdrawal and is not sedated; the first dose must not exceed 30 mg. If withdrawal persists after 2–4 h, give 5–10 mg more. Further titration per label. Disperse in water or juice; never inject.",[52,54,56],{"source":33,"section":53},"2.5",{"source":33,"section":55},"2.1",{"source":33,"section":57},"2.4",[59],{"id":60,"severity":61,"text":62,"refs":65},"ci","block",{"fa":63,"en":64},"دپرسیون تنفسی قابل‌توجه؛ آسم حاد یا شدید بدون پایش؛ انسداد گوارشی یا ایلئوس؛ حساسیت.","Significant respiratory depression; acute or severe asthma without monitoring; GI obstruction or ileus; hypersensitivity.",[66],{"source":33,"section":67},"4",[69],{"text":70,"refs":73},{"fa":71,"en":72},"هشدار جعبه‌ای: دپرسیون تنفسی کشنده (اوج اثر دیرتر و طولانی‌تر از اثر ضددرد)، طولانی شدن QT، مصرف تصادفی در کودک و تداخل با بنزودیازپین‌ها.","Boxed warning: life-threatening respiratory depression (peak later and longer than the analgesic effect), QT prolongation, accidental pediatric ingestion and benzodiazepine interactions.",[74,76],{"source":33,"section":75},"Boxed Warning",{"source":33,"section":77},"2.2",[],[],[],{"status":82,"reviewer":83,"date":83},"unverified",null,[],[86],"N07BC02",{"status":88,"forms":89,"refs":154},"registered",[90,94,98,102,106,110,114,118,122,126,130,134,138,142,146,150],{"code":91,"en":92,"fa":93},"01586","METHADONE 10MG\u002FML AMP","آمپول متادون ۱۰ میلی‌گرم \u002F میلی‌لیتر",{"code":95,"en":96,"fa":97},"10456","METHADONE 25MG\u002F5ML 120ML ORAL SOLUTION","محلول خوراکی متادون ۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":99,"en":100,"fa":101},"02444","METHADONE 25MG\u002F5ML 250ML ORAL SOLUTION","محلول خوراکی متادون ۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",{"code":103,"en":104,"fa":105},"00818","METHADONE 5MG TAB","قرص متادون ۵ میلی‌گرم",{"code":107,"en":108,"fa":109},"00819","METHADONE 5MG\u002F1ML AMP","آمپول متادون ۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":111,"en":112,"fa":113},"14076","METHADONE 5MG\u002F5ML 120ML SYRUP","شربت متادون ۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":115,"en":116,"fa":117},"06394","METHADONE 5MG\u002F5ML 250ML SYRUP","شربت متادون ۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",{"code":119,"en":120,"fa":121},"13770","METHADONE HCL 20MG DISPERSIBLE TAB","قرص پراکنده‌شونده متادون هیدروکلراید ۲۰ میلی‌گرم",{"code":123,"en":124,"fa":125},"02705","METHADONE HCL 20MG TAB","قرص متادون هیدروکلراید ۲۰ میلی‌گرم",{"code":127,"en":128,"fa":129},"13771","METHADONE HCL 40MG DISPERSIBLE TAB","قرص پراکنده‌شونده متادون هیدروکلراید ۴۰ میلی‌گرم",{"code":131,"en":132,"fa":133},"02706","METHADONE HCL 40MG TAB","قرص متادون هیدروکلراید ۴۰ میلی‌گرم",{"code":135,"en":136,"fa":137},"01362","METHADONE POWDER","پودر متادون",{"code":139,"en":140,"fa":141},"51978","METHADONE HYDROCHLORIDE SOLUTION ORAL 5 mg\u002F5 mL 240 mL","محلول خوراکی متادون هیدروکلراید ۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۴۰ میلی‌لیتر",{"code":143,"en":144,"fa":145},"51871","METHADONE HYDROCHLORIDE TABLET, FOR SUSPENSION ORAL 40 mg","سوسپانسیون خوراکی متادون هیدروکلراید ۴۰ میلی‌گرم",{"code":147,"en":148,"fa":149},"51870","METHADONE HYDROCHLORIDE TABLET, FOR SUSPENSION ORAL 20 mg","سوسپانسیون خوراکی متادون هیدروکلراید ۲۰ میلی‌گرم",{"code":151,"en":152,"fa":153},"52833","METHADONE HYDROCHLORIDE SOLUTION ORAL 25 mg\u002F5 mL 15 mL","محلول خوراکی متادون هیدروکلراید ۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۵ میلی‌لیتر",[155],{"source":156,"section":157,"url":158},"darooyab-generic","G-127\u002FMethadone","https:\u002F\u002Fwww.darooyab.ir\u002FG-127\u002FMethadone",{"kind":160,"refs":161,"id":164},"ANDA",[162],{"source":33,"section":163},"SPL approval \u002F marketing category","ANDA075082",[166,169,173,176,179,182],{"kind":167,"url":168,"label":164},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=075082",{"kind":170,"url":171,"label":172},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=c54baaee-8ea4-45f5-a5c8-bb84cf86832f","FDA Methadone 40 mg",{"kind":174,"url":175,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682134.html",{"kind":174,"url":177,"label":178},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa624014.html","Methadone Injection",{"kind":180,"url":181,"label":86},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N07BC02",{"kind":183,"url":158,"label":8},"darooyab",{"pregnancy":185,"lactation":194,"pediatric":202,"geriatric":211,"reproductive":219},{"level":186,"text":187,"quote":190,"refs":191},"caution",{"fa":188,"en":189},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The majority of available data from clinical trials, observational studies, case series, and case reports on methadone use in pregnancy do not indicate an increased risk of major malformations specifically due to methadone.",[192],{"source":33,"section":193},"8.1",{"level":186,"text":195,"quote":198,"refs":199},{"fa":196,"en":197},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Based on two small clinical studies, methadone was present in low levels in human milk, but the exposed infants in these studies did not show adverse reactions.",[200],{"source":33,"section":201},"8.2",{"level":203,"text":204,"quote":207,"refs":208},"not-established",{"fa":205,"en":206},"برچسب: زیر ۱۸ سال ثابت نشده. مصرف تصادفی در کودک کشنده است.","Label: not established under 18. Accidental ingestion by a child is fatal.","The safety, effectiveness, and pharmacokinetics of methadone in pediatric patients below the age of 18 years have not been established.",[209],{"source":33,"section":210},"8.4",{"level":186,"text":212,"quote":215,"refs":216},{"fa":213,"en":214},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[217],{"source":33,"section":218},"8.5",{"level":186,"text":220,"quote":223,"refs":224},{"fa":221,"en":222},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility The effect of methadone hydrochloride tablets for oral suspension on fertility is unknown.",[225],{"source":33,"section":226},"8.3",1792115188031]