[{"data":1,"prerenderedAt":200},["ShallowReactive",2],{"drug-lumateperone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":51,"contraindications":90,"warnings":100,"renal":115,"monitoring":116,"interactions":117,"review":118,"examples":121,"atc":130,"iran":132,"usApproval":139,"links":145,"populations":159},"lumateperone",1,{"fa":7,"en":8},"لوماتپرون","Lumateperone","nervous-system",{"fa":11,"en":12},"ضدروان‌پریشی آتیپیک","Atypical antipsychotic",[14],{"name":15,"market":16},"Caplyta","US",[18,19,7],"caplyta","کاپلیتا",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-42","capsule","oral","42 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},42,"mg",false,[16],[32],{"source":33,"section":34},"fda-caplyta","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"cap-21","21 mg capsule",{"amount":39,"unit":28,"perUnit":23,"scored":29},21,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"cap-10-5","10.5 mg capsule",{"amount":47,"unit":28,"perUnit":23,"scored":29},10.5,[16],[50],{"source":33,"section":34},[52,78],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":28,"dose":63,"refs":64,"allowedFormulations":67,"notes":68},"scz","schizophrenia",{"fa":56,"en":57},"اسکیزوفرنی بزرگسال — ۴۲ mg یک بار در روز (بدون تیتراسیون)","Schizophrenia, adults — 42 mg once daily (no titration)",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":27,"dosesPerDay":5},[65],{"source":33,"section":66},"2.1",[22],[69],{"text":70,"refs":73},{"fa":71,"en":72},"نارسایی متوسط\u002Fشدید کبد یا مهارکننده متوسط CYP3A4: ۲۱ mg؛ مهارکننده قوی CYP3A4: ۱۰٫۵ mg.","Moderate\u002Fsevere hepatic impairment or moderate CYP3A4 inhibitors: 21 mg; strong CYP3A4 inhibitors: 10.5 mg.",[74,76],{"source":33,"section":75},"2.3",{"source":33,"section":77},"2.2",{"id":79,"disease":80,"label":81,"population":84,"type":62,"unit":28,"dose":86,"refs":87,"allowedFormulations":89},"bpd","bipolar-depression",{"fa":82,"en":83},"افسردگی دوقطبی بزرگسال — ۴۲ mg یک بار در روز","Bipolar depression, adults — 42 mg once daily",{"minAge":85},{"value":60,"unit":61},{"perDose":27,"dosesPerDay":5},[88],{"source":33,"section":66},[22],[91],{"id":92,"severity":93,"text":94,"refs":97},"hyper","block",{"fa":95,"en":96},"سابقه حساسیت به لوماتپرون.","History of hypersensitivity to lumateperone.",[98],{"source":33,"section":99},"4",[101,108],{"text":102,"refs":105},{"fa":103,"en":104},"هشدار جعبه‌ای: افزایش مرگ در سالمندان با سایکوز دمانس؛ افکار خودکشی در کودکان و جوانان (ضدافسردگی).","Boxed warning: increased mortality in elderly patients with dementia-related psychosis; suicidal thoughts in children and young adults (antidepressant).",[106],{"source":33,"section":107},"Boxed Warning",{"text":109,"refs":112},{"fa":110,"en":111},"NMS؛ دیسکینزی دیررس؛ تغییرات متابولیک؛ لکوپنی؛ افت فشار وضعیتی؛ تشنج.","NMS; tardive dyskinesia; metabolic changes; leukopenia; orthostatic hypotension; seizures.",[113],{"source":33,"section":114},"5",[],[],[],{"status":119,"reviewer":120,"date":120},"unverified",null,[122,127],{"regimen":53,"formulation":22,"input":123,"expect":126},{"ageYears":124,"weightKg":125},30,70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":79,"formulation":22,"input":128,"expect":129},{"ageYears":124,"weightKg":125},{"perDose":27,"tabletsPerDoseRounded":5},[131],"N05AD10",{"status":133,"refs":134},"not-found",[135],{"source":136,"section":137,"url":138},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Lumateperone",{"kind":140,"refs":141,"id":144},"NDA",[142],{"source":33,"section":143},"SPL approval \u002F marketing category","NDA209500",[146,149,153,156],{"kind":147,"url":148,"label":144},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=209500",{"kind":150,"url":151,"label":152},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=db730b06-6351-47fd-8183-e61e61bbead5","FDA Caplyta",{"kind":154,"url":155,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa620014.html",{"kind":157,"url":158,"label":131},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AD10",{"pregnancy":160,"lactation":169,"pediatric":177,"geriatric":185,"reproductive":192},{"level":161,"text":162,"quote":165,"refs":166},"caution",{"fa":163,"en":164},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates exposed to antipsychotic drugs during the third trimester are at risk for extrapyramidal and\u002For withdrawal symptoms following delivery (see Clinical Considerations ).",[167],{"source":33,"section":168},"8.1",{"level":161,"text":170,"quote":173,"refs":174},{"fa":171,"en":172},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Lumateperone and its metabolites are present in human breast milk in low amounts.",[175],{"source":33,"section":176},"8.2",{"level":178,"text":179,"quote":182,"refs":183},"avoid",{"fa":180,"en":181},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Suicidal Thoughts and Behaviors Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adults in short-term studies.",[184],{"source":33,"section":107},{"level":178,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.",[191],{"source":33,"section":107},{"level":161,"text":193,"quote":196,"refs":197},{"fa":194,"en":195},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Based on findings from animal studies, lumateperone may impair male and female fertility [see Nonclinical Toxicology (13.1) ].",[198],{"source":33,"section":199},"8.3",1792191553401]