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do not crush or chew.",[73,74],{"source":32,"section":65},{"source":32,"section":75},"2.2",{"id":77,"disease":78,"label":79,"population":82,"type":61,"unit":28,"dose":84,"refs":85,"allowedFormulations":87},"cic","chronic-idiopathic-constipation",{"fa":80,"en":81},"یبوست مزمن ایدیوپاتیک — بزرگسال: ۱۴۵ mcg (یا ۷۲ mcg) یک بار در روز","Chronic idiopathic constipation — adult: 145 mcg (or 72 mcg) once daily",{"minAge":83},{"value":59,"unit":60},{"perDose":38,"dosesPerDay":5},[86],{"source":32,"section":65},[35],{"id":89,"disease":53,"label":90,"population":93,"type":61,"unit":28,"dose":97,"refs":98,"allowedFormulations":100},"ibsc-child",{"fa":91,"en":92},"IBS-C — کودک ۷ سال به بالا: ۱۴۵ mcg یک بار در روز","IBS-C — child ≥7 y: 145 mcg once daily",{"minAge":94,"maxAge":96},{"value":95,"unit":60},7,{"value":59,"unit":60},{"perDose":38,"dosesPerDay":5},[99],{"source":32,"section":65},[35],{"id":102,"disease":103,"label":104,"population":107,"type":61,"unit":28,"dose":111,"refs":112,"allowedFormulations":114},"fc-child","constipation",{"fa":105,"en":106},"یبوست عملکردی — کودک ۲ سال به بالا: ۷۲ mcg یک بار در روز","Functional constipation — child ≥2 y: 72 mcg once daily",{"minAge":108,"maxAge":110},{"value":109,"unit":60},2,{"value":59,"unit":60},{"perDose":27,"dosesPerDay":5},[113],{"source":32,"section":65},[22],[116,127],{"id":117,"severity":118,"text":119,"refs":122,"rule":125},"lt2","block",{"fa":120,"en":121},"زیر ۲ سال (خطر کم‌آبی شدید).","Under 2 years (risk of serious dehydration).",[123],{"source":32,"section":124},"4",{"maxAge":126},{"value":109,"unit":60},{"id":128,"severity":118,"text":129,"refs":132},"obst",{"fa":130,"en":131},"انسداد مکانیکی گوارشی شناخته‌شده یا مشکوک.","Known or suspected mechanical GI obstruction.",[133],{"source":32,"section":124},[],[],[],[],{"status":139,"reviewer":140,"date":140},"unverified",null,[142,147,150,155],{"regimen":52,"formulation":43,"input":143,"expect":146},{"ageYears":144,"weightKg":145},35,60,{"perDose":46,"tabletsPerDoseRounded":5},{"regimen":77,"formulation":35,"input":148,"expect":149},{"ageYears":144,"weightKg":145},{"perDose":38,"tabletsPerDoseRounded":5},{"regimen":89,"formulation":35,"input":151,"expect":154},{"ageYears":152,"weightKg":153},10,30,{"perDose":38,"tabletsPerDoseRounded":5},{"regimen":102,"formulation":22,"input":156,"expect":159},{"ageYears":157,"weightKg":158},4,16,{"perDose":27,"tabletsPerDoseRounded":5},[161],"A06AX04",{"status":163,"forms":164,"refs":177},"registered",[165,169,173],{"code":166,"en":167,"fa":168},"50833","LINACLOTIDE 145 mcg CAPSULE","کپسول لیناکلوتاید ۱۴۵ میکروگرم",{"code":170,"en":171,"fa":172},"53263","LINACLOTIDE 72 mcg CAPSULE","کپسول لیناکلوتاید ۷۲ میکروگرم",{"code":174,"en":175,"fa":176},"52508","LINACLOTIDE 290 mcg CAPSULE","کپسول لیناکلوتاید ۲۹۰ میکروگرم",[178],{"source":179,"section":180,"url":181},"darooyab-generic","G-5499\u002FLinaclotide","https:\u002F\u002Fwww.darooyab.ir\u002FG-5499\u002FLinaclotide",{"kind":183,"refs":184,"id":187},"NDA",[185],{"source":32,"section":186},"SPL approval \u002F marketing category","NDA202811",[189,192,196,199,202],{"kind":190,"url":191,"label":187},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=202811",{"kind":193,"url":194,"label":195},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=09beda19-56d6-4a56-afdc-9a77b70b2ef3","FDA Linzess",{"kind":197,"url":198,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa613007.html",{"kind":200,"url":201,"label":161},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A06AX04",{"kind":203,"url":181,"label":8},"darooyab",{"lactation":205,"pediatric":214,"geriatric":222,"pregnancy":230},{"level":206,"text":207,"quote":210,"refs":211},"ok",{"fa":208,"en":209},"برچسب: مواجهه شیرخوار انتظار نمی‌رود.","Label: infant exposure not expected.","Maternal use of LINZESS is not expected to result in exposure to linaclotide or its active metabolite in breastfed infants.",[212],{"source":32,"section":213},"8.2",{"level":215,"text":216,"quote":219,"refs":220},"caution",{"fa":217,"en":218},"برچسب: زیر ۲ سال ممنوع (کم‌آبی شدید)؛ یبوست عملکردی از ۲ سال و IBS-C از ۷ سال تأیید شده.","Label: contraindicated under 2 years (serious dehydration); approved for functional constipation from 2 y and IBS-C from 7 y.","LINZESS is contraindicated in: Patients less than 2 years of age due to the risk of serious dehydration",[221],{"source":32,"section":124},{"level":215,"text":223,"quote":226,"refs":227},{"fa":224,"en":225},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy.",[228],{"source":32,"section":229},"8.5",{"level":215,"quote":231,"text":232,"refs":235},"مصرف در بارداری لیناکلوتاید گروه C در شرايط خاص و نظارت ويژه پزشك قابل استفاده است:",{"fa":233,"en":234},"دارویاب: گروه C — فقط اگر فایده بیشتر از خطر باشد.","Darooyab: category C — only if benefit outweighs risk.",[236],{"source":179,"section":237,"url":181},"G-5499\u002FLinaclotide — مصرف در بارداری",1792111459218]