[{"data":1,"prerenderedAt":146},["ShallowReactive",2],{"drug-lifitegrast":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":33,"contraindications":57,"warnings":67,"renal":68,"monitoring":69,"interactions":70,"review":71,"examples":74,"atc":80,"iran":82,"usApproval":89,"links":95,"populations":110},"lifitegrast",1,{"fa":7,"en":8},"لیفیتگراست","Lifitegrast","sensory-organs",{"fa":11,"en":12},"آنتاگونیست LFA-1 (چشمی)","LFA-1 antagonist (ophthalmic)",[14],{"name":15,"market":16},"Xiidra","US",[18,19,7],"xiidra","زیدرا",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":28,"refs":29},"drops","eye-drops","ophthalmic","5% (50 mg\u002FmL) single-use containers",{"amount":5,"unit":27,"perUnit":27},"drop",[16],[30],{"source":31,"section":32},"fda-xiidra","3",[34],{"id":35,"disease":36,"label":37,"population":40,"type":44,"unit":27,"dose":45,"refs":47,"notes":50},"dry","dry-eye",{"fa":38,"en":39},"خشکی چشم — یک قطره در هر چشم دو بار در روز (حدود ۱۲ ساعت فاصله)","Dry eye disease — 1 drop in each eye twice daily (about 12 h apart)",{"minAge":41},{"value":42,"unit":43},17,"year","fixed",{"perDose":5,"dosesPerDay":46},2,[48],{"source":31,"section":49},"2",[51],{"text":52,"refs":55},{"fa":53,"en":54},"ظرف یک‌بارمصرف پس از استفاده دور ریخته شود؛ لنز تماسی پیش از قطره برداشته و ۱۵ دقیقه بعد گذاشته شود.","Discard the single-use container after use; remove contact lenses before and reinsert 15 min after.",[56],{"source":31,"section":49},[58],{"id":59,"severity":60,"text":61,"refs":64},"hyper","block",{"fa":62,"en":63},"حساسیت به لیفیتگراست.","Hypersensitivity to lifitegrast.",[65],{"source":31,"section":66},"4",[],[],[],[],{"status":72,"reviewer":73,"date":73},"unverified",null,[75],{"regimen":35,"formulation":22,"input":76,"expect":79},{"ageYears":77,"weightKg":78},45,65,{"perDose":5},[81],"S01XA25",{"status":83,"refs":84},"not-found",[85],{"source":86,"section":87,"url":88},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Lifitegrast",{"kind":90,"refs":91,"id":94},"NDA",[92],{"source":31,"section":93},"SPL approval \u002F marketing category","NDA208073",[96,99,103,107],{"kind":97,"url":98,"label":94},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=208073",{"kind":100,"url":101,"label":102},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=8589d376-ac10-4ddb-9c53-2e0c8d5675c4","FDA Xiidra",{"kind":104,"url":105,"label":106},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa616039.html","Lifitegrast Ophthalmic",{"kind":108,"url":109,"label":81},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=S01XA25",{"pregnancy":111,"lactation":120,"pediatric":128,"geriatric":137},{"level":112,"text":113,"quote":116,"refs":117},"caution",{"fa":114,"en":115},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no available data on Xiidra use in pregnant women to inform any drug-associated risks.",[118],{"source":31,"section":119},"8.1",{"level":112,"text":121,"quote":124,"refs":125},{"fa":122,"en":123},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of lifitegrast in human milk, the effects on the breastfed infant, or the effects on milk production.",[126],{"source":31,"section":127},"8.2",{"level":129,"text":130,"quote":133,"refs":134},"not-established",{"fa":131,"en":132},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and efficacy in pediatric patients below the age of 17 years have not been established.",[135],{"source":31,"section":136},"8.4",{"level":138,"text":139,"quote":142,"refs":143},"ok",{"fa":140,"en":141},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness have been observed between elderly and younger adult patients.",[144],{"source":31,"section":145},"8.5",1792191552448]