[{"data":1,"prerenderedAt":306},["ShallowReactive",2],{"drug-levothyroxine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":117,"contraindications":254,"warnings":264,"renal":272,"monitoring":273,"interactions":274,"review":275,"examples":278},"levothyroxine",1,{"fa":7,"en":8},"لووتیروکسین","Levothyroxine","endocrine",{"fa":11,"en":12},"هورمون تیروئید","Thyroid hormone",[14],{"name":15,"market":16},"Synthroid","US",[7,18,19,20,21],"لوتیروکسین","T4","synthroid","قرص تیروئید",[23,37,45,53,61,69,77,85,93,101,109],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"tab-25","tablet","oral","25 mcg tablet",{"amount":29,"unit":30,"perUnit":25,"scored":31},25,"mcg",true,[16],[34],{"source":35,"section":36},"fda-levothyroxine","3",{"id":38,"form":25,"route":26,"label":39,"concentration":40,"markets":42,"refs":43},"tab-50","50 mcg tablet",{"amount":41,"unit":30,"perUnit":25,"scored":31},50,[16],[44],{"source":35,"section":36},{"id":46,"form":25,"route":26,"label":47,"concentration":48,"markets":50,"refs":51},"tab-75","75 mcg tablet",{"amount":49,"unit":30,"perUnit":25,"scored":31},75,[16],[52],{"source":35,"section":36},{"id":54,"form":25,"route":26,"label":55,"concentration":56,"markets":58,"refs":59},"tab-88","88 mcg tablet",{"amount":57,"unit":30,"perUnit":25,"scored":31},88,[16],[60],{"source":35,"section":36},{"id":62,"form":25,"route":26,"label":63,"concentration":64,"markets":66,"refs":67},"tab-100","100 mcg tablet",{"amount":65,"unit":30,"perUnit":25,"scored":31},100,[16],[68],{"source":35,"section":36},{"id":70,"form":25,"route":26,"label":71,"concentration":72,"markets":74,"refs":75},"tab-112","112 mcg tablet",{"amount":73,"unit":30,"perUnit":25,"scored":31},112,[16],[76],{"source":35,"section":36},{"id":78,"form":25,"route":26,"label":79,"concentration":80,"markets":82,"refs":83},"tab-125","125 mcg tablet",{"amount":81,"unit":30,"perUnit":25,"scored":31},125,[16],[84],{"source":35,"section":36},{"id":86,"form":25,"route":26,"label":87,"concentration":88,"markets":90,"refs":91},"tab-137","137 mcg tablet",{"amount":89,"unit":30,"perUnit":25,"scored":31},137,[16],[92],{"source":35,"section":36},{"id":94,"form":25,"route":26,"label":95,"concentration":96,"markets":98,"refs":99},"tab-150","150 mcg tablet",{"amount":97,"unit":30,"perUnit":25,"scored":31},150,[16],[100],{"source":35,"section":36},{"id":102,"form":25,"route":26,"label":103,"concentration":104,"markets":106,"refs":107},"tab-175","175 mcg tablet",{"amount":105,"unit":30,"perUnit":25,"scored":31},175,[16],[108],{"source":35,"section":36},{"id":110,"form":25,"route":26,"label":111,"concentration":112,"markets":114,"refs":115},"tab-200","200 mcg tablet",{"amount":113,"unit":30,"perUnit":25,"scored":31},200,[16],[116],{"source":35,"section":36},[118,148,167,185,203,222,235],{"id":119,"disease":120,"label":121,"population":124,"type":131,"unit":30,"dose":132,"refs":135,"notes":138},"ped-0-3m","hypothyroidism",{"fa":122,"en":123},"کم‌کاری تیروئید — ۰ تا ۳ ماه: 10 تا 15 mcg\u002Fkg\u002Fday","Hypothyroidism — 0–3 months: 10–15 mcg\u002Fkg\u002Fday",{"minAge":125,"maxAge":128},{"value":126,"unit":127},0,"day",{"value":129,"unit":130},3,"month","weightBased",{"perKgPerDay":133,"perKgPerDayMax":134,"dividedDoses":5},10,15,[136],{"source":35,"section":137},"2.3, Table 2",[139],{"text":140,"refs":143},{"fa":141,"en":142},"دوز شروع روزانه؛ هر ۲ هفته بر اساس TSH یا T4 آزاد تنظیم شود. ناشتا، ۳۰ تا ۶۰ دقیقه قبل از صبحانه.","Starting daily dose; titrate every 2 weeks by TSH or free T4. Empty stomach, 30–60 min before breakfast.",[144,146],{"source":35,"section":145},"2.3",{"source":35,"section":147},"2.1",{"id":149,"disease":120,"label":150,"population":153,"type":131,"unit":30,"dose":157,"refs":159,"notes":161},"ped-3-6m",{"fa":151,"en":152},"کم‌کاری تیروئید — ۳ تا ۶ ماه: 8 تا 10 mcg\u002Fkg\u002Fday","Hypothyroidism — 3–6 months: 8–10 mcg\u002Fkg\u002Fday",{"minAge":154,"maxAge":155},{"value":129,"unit":130},{"value":156,"unit":130},6,{"perKgPerDay":158,"perKgPerDayMax":133,"dividedDoses":5},8,[160],{"source":35,"section":137},[162],{"text":163,"refs":164},{"fa":141,"en":142},[165,166],{"source":35,"section":145},{"source":35,"section":147},{"id":168,"disease":120,"label":169,"population":172,"type":131,"unit":30,"dose":176,"refs":177,"notes":179},"ped-6-12m",{"fa":170,"en":171},"کم‌کاری تیروئید — ۶ تا ۱۲ ماه: 6 تا 8 mcg\u002Fkg\u002Fday","Hypothyroidism — 6–12 months: 6–8 mcg\u002Fkg\u002Fday",{"minAge":173,"maxAge":174},{"value":156,"unit":130},{"value":5,"unit":175},"year",{"perKgPerDay":156,"perKgPerDayMax":158,"dividedDoses":5},[178],{"source":35,"section":137},[180],{"text":181,"refs":182},{"fa":141,"en":142},[183,184],{"source":35,"section":145},{"source":35,"section":147},{"id":186,"disease":120,"label":187,"population":190,"type":131,"unit":30,"dose":193,"refs":195,"notes":197},"ped-1-5y",{"fa":188,"en":189},"کم‌کاری تیروئید — ۱ تا ۵ سال: 5 تا 6 mcg\u002Fkg\u002Fday","Hypothyroidism — 1–5 years: 5–6 mcg\u002Fkg\u002Fday",{"minAge":191,"maxAge":192},{"value":5,"unit":175},{"value":156,"unit":175},{"perKgPerDay":194,"perKgPerDayMax":156,"dividedDoses":5},5,[196],{"source":35,"section":137},[198],{"text":199,"refs":200},{"fa":141,"en":142},[201,202],{"source":35,"section":145},{"source":35,"section":147},{"id":204,"disease":120,"label":205,"population":208,"type":131,"unit":30,"dose":212,"refs":214,"notes":216},"ped-6-12y",{"fa":206,"en":207},"کم‌کاری تیروئید — ۶ تا ۱۲ سال: 4 تا 5 mcg\u002Fkg\u002Fday","Hypothyroidism — 6–12 years: 4–5 mcg\u002Fkg\u002Fday",{"minAge":209,"maxAge":210},{"value":156,"unit":175},{"value":211,"unit":175},13,{"perKgPerDay":213,"perKgPerDayMax":194,"dividedDoses":5},4,[215],{"source":35,"section":137},[217],{"text":218,"refs":219},{"fa":141,"en":142},[220,221],{"source":35,"section":145},{"source":35,"section":147},{"id":223,"disease":120,"label":224,"population":227,"type":131,"unit":30,"dose":231,"refs":233},"ped-adolescent",{"fa":225,"en":226},"بالای ۱۲ سال با رشد ناکامل — ۲ تا ۳ mcg\u002Fkg\u002Fday",">12 years, growth incomplete — 2–3 mcg\u002Fkg\u002Fday",{"minAge":228,"maxAge":229},{"value":211,"unit":175},{"value":230,"unit":175},18,{"perKgPerDay":232,"perKgPerDayMax":129,"dividedDoses":5},2,[234],{"source":35,"section":137},{"id":236,"disease":120,"label":237,"population":240,"type":131,"unit":30,"dose":242,"refs":244,"notes":247},"adult",{"fa":238,"en":239},"بزرگسال — جایگزینی کامل ۱٫۶ mcg\u002Fkg\u002Fday","Adults — full replacement 1.6 mcg\u002Fkg\u002Fday",{"minAge":241},{"value":230,"unit":175},{"perKgPerDay":243,"dividedDoses":5},1.6,[245],{"source":35,"section":246},"2.3, Table 1",[248],{"text":249,"refs":252},{"fa":250,"en":251},"بیماران قلبی یا در خطر فیبریلاسیون دهلیزی: دوز شروع کمتر. افزایش ۱۲٫۵ تا ۲۵ mcg هر ۴ تا ۶ هفته.","Cardiac disease or AF risk: lower start. Titrate 12.5–25 mcg every 4–6 weeks.",[253],{"source":35,"section":246},[255],{"id":256,"severity":257,"text":258,"refs":261},"adrenal","block",{"fa":259,"en":260},"نارسایی آدرنال اصلاح‌نشده.","Uncorrected adrenal insufficiency.",[262],{"source":35,"section":263},"4",[265],{"text":266,"refs":269},{"fa":267,"en":268},"هشدار جعبه‌ای: برای درمان چاقی یا کاهش وزن مصرف نشود.","Boxed warning: not for obesity or weight loss.",[270],{"source":35,"section":271},"WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS",[],[],[],{"status":276,"reviewer":277,"date":277},"unverified",null,[279,282,287,291,295,298,302],{"regimen":186,"formulation":38,"input":280,"expect":281},{"ageYears":129,"weightKg":133},{"perDose":41,"tabletsPerDoseRounded":5},{"regimen":119,"formulation":24,"input":283,"expect":284},{"ageMonths":5,"weightKg":213},{"perDose":285,"tabletsPerDoseRounded":286},40,1.5,{"regimen":149,"formulation":24,"input":288,"expect":289},{"ageMonths":213,"weightKg":156},{"perDose":290,"tabletsPerDoseRounded":232},48,{"regimen":168,"formulation":24,"input":292,"expect":294},{"ageMonths":293,"weightKg":158},9,{"perDose":290,"tabletsPerDoseRounded":232},{"regimen":204,"formulation":62,"input":296,"expect":297},{"ageYears":293,"weightKg":29},{"perDose":65},{"regimen":223,"formulation":62,"input":299,"expect":301},{"ageYears":300,"weightKg":41},14,{"perDose":65},{"regimen":236,"formulation":70,"input":303,"expect":305},{"ageYears":285,"weightKg":304},70,{"perDose":73,"tabletsPerDoseRounded":5},1792078537135]