[{"data":1,"prerenderedAt":186},["ShallowReactive",2],{"drug-levomilnacipran":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":21,"regimens":60,"contraindications":86,"warnings":96,"renal":111,"monitoring":121,"interactions":122,"review":123,"examples":126,"atc":131,"iran":133,"usApproval":140,"links":146,"populations":160},"levomilnacipran",1,{"fa":7,"en":8},"لِوومیلناسیپران","Levomilnacipran","nervous-system",{"fa":11,"en":11},"SNRI",[13],{"name":14,"market":15},"Fetzima","US",[17,18,19,20],"fetzima","فتزیما","لووميلناسیپران","لوومیلناسیپران",[22,36,44,52],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"er-40","capsule","oral","40 mg ER capsule (swallow whole)",{"amount":28,"unit":29,"perUnit":24,"scored":30},40,"mg",false,[15],[33],{"source":34,"section":35},"fda-fetzima","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"er-20","20 mg ER capsule (swallow whole)",{"amount":40,"unit":29,"perUnit":24,"scored":30},20,[15],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"er-80","80 mg ER capsule (swallow whole)",{"amount":48,"unit":29,"perUnit":24,"scored":30},80,[15],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"er-120","120 mg ER capsule (swallow whole)",{"amount":56,"unit":29,"perUnit":24,"scored":30},120,[15],[59],{"source":34,"section":35},[61],{"id":62,"disease":62,"label":63,"population":66,"type":70,"unit":29,"dose":71,"refs":72,"notes":75},"mdd",{"fa":64,"en":65},"افسردگی اساسی بزرگسال — ۴۰ تا ۱۲۰ mg یک بار در روز","Major depressive disorder, adults — 40–120 mg once daily",{"minAge":67},{"value":68,"unit":69},18,"year","fixed",{"perDose":28,"perDoseMax":56,"dosesPerDay":5},[73],{"source":34,"section":74},"2.1",[76],{"text":77,"refs":80},{"fa":78,"en":79},"شروع ۲۰ mg دو روز، سپس ۴۰ mg؛ گام ۴۰ mg با فاصله ۲ روز یا بیشتر. کپسول باز یا جویده نشود. با مهارکننده قوی CYP3A4 حداکثر ۸۰ mg. قطع تدریجی.","Start 20 mg for 2 days, then 40 mg; 40 mg steps at ≥2-day intervals. Do not open or chew. With strong CYP3A4 inhibitors max 80 mg. Taper when stopping.",[81,82,84],{"source":34,"section":74},{"source":34,"section":83},"2.6",{"source":34,"section":85},"2.4",[87],{"id":88,"severity":89,"text":90,"refs":93},"ci","block",{"fa":91,"en":92},"حساسیت به لووميلناسیپران یا میلناسیپران؛ مهارکننده MAO همزمان، ظرف ۷ روز پس از قطع این دارو یا ۱۴ روز پس از قطع MAOI؛ لینزولید یا متیلن بلو وریدی.","Hypersensitivity to levomilnacipran or milnacipran; MAOIs concomitantly, within 7 days of stopping this drug or 14 days of stopping the MAOI; linezolid or IV methylene blue.",[94],{"source":34,"section":95},"4",[97,104],{"text":98,"refs":101},{"fa":99,"en":100},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان و جوانان — پایش بدتر شدن بالینی.","Boxed warning: increased suicidal thoughts and behaviours in children and young adults — monitor for clinical worsening.",[102],{"source":34,"section":103},"Boxed Warning",{"text":105,"refs":108},{"fa":106,"en":107},"سندرم سروتونین؛ افزایش فشار خون و ضربان؛ خونریزی؛ گلوکوم زاویه بسته؛ احتباس ادرار؛ هیپوناترمی.","Serotonin syndrome; raised blood pressure and heart rate; bleeding; angle-closure glaucoma; urinary retention; hyponatraemia.",[109],{"source":34,"section":110},"5",[112],{"egfrBelow":113,"severity":114,"text":115,"refs":118},60,"warn",{"fa":116,"en":117},"ClCr ۳۰ تا ۵۹: حداکثر ۸۰ mg؛ ۱۵ تا ۲۹: حداکثر ۴۰ mg. ESRD توصیه نمی‌شود.","CrCl 30–59: max 80 mg; 15–29: max 40 mg. ESRD not recommended.",[119],{"source":34,"section":120},"2.3",[],[],{"status":124,"reviewer":125,"date":125},"unverified",null,[127],{"regimen":62,"formulation":23,"input":128,"expect":130},{"ageYears":28,"weightKg":129},70,{"perDose":28,"tabletsPerDoseRounded":5,"upperPerDose":56},[132],"N06AX28",{"status":134,"refs":135},"not-found",[136],{"source":137,"section":138,"url":139},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Levomilnacipran",{"kind":141,"refs":142,"id":145},"NDA",[143],{"source":34,"section":144},"SPL approval \u002F marketing category","NDA204168",[147,150,154,157],{"kind":148,"url":149,"label":145},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204168",{"kind":151,"url":152,"label":153},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f371258d-91b3-4b6a-ac99-434a1964c3af","FDA Fetzima",{"kind":155,"url":156,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa613048.html",{"kind":158,"url":159,"label":132},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AX28",{"pregnancy":161,"lactation":170,"pediatric":178},{"level":162,"text":163,"quote":166,"refs":167},"caution",{"fa":164,"en":165},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Based on data from published observational studies, exposure to SNRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions ( 5.5 ) and Clinical Considerations] .",[168],{"source":34,"section":169},"8.1",{"level":162,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no available data on the presence of levomilnacipran in human milk; however, racemic milnacipran is present in human milk (see Data ).",[176],{"source":34,"section":177},"8.2",{"level":179,"text":180,"quote":183,"refs":184},"avoid",{"fa":181,"en":182},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies.",[185],{"source":34,"section":103},1792191552040]