[{"data":1,"prerenderedAt":278},["ShallowReactive",2],{"drug-leucovorin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":46,"contraindications":100,"warnings":110,"renal":117,"monitoring":118,"interactions":119,"review":120,"examples":123,"atc":136,"iran":138,"links":218,"populations":239,"usApproval":273},"leucovorin",1,{"fa":7,"en":8},"لکوورین (فولینیک اسید)","Leucovorin (folinic acid)","various",{"fa":11,"en":12},"آنالوگ فولات (نجات‌دهنده)","Folate analogue (rescue agent)",[14],{"name":15,"market":16},"Leucovorin","US",[18,19,20,21,22],"folinic acid","calcium folinate","فولینیک اسید","لکوورین","کلسیم فولینات",[24,38],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"vial-100","powder-for-injection","iv","100 mg vial",{"amount":30,"unit":31,"perUnit":32},100,"mg","vial",[16],[35],{"source":36,"section":37},"fda-leucovorin","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"vial-350","350 mg vial",{"amount":42,"unit":31,"perUnit":32},350,[16],[45],{"source":36,"section":37},[47,70],{"id":48,"disease":49,"label":50,"population":53,"type":54,"unit":31,"dose":55,"refs":58,"notes":61},"mtx","methotrexate-toxicity",{"fa":51,"en":52},"نجات پس از متوترکسات با دوز بالا — ۱۵ mg (حدود ۱۰ mg\u002Fm²) هر ۶ ساعت، ۱۰ دوز از ۲۴ ساعت پس از شروع متوترکسات","Rescue after high-dose methotrexate — 15 mg (about 10 mg\u002Fm²) every 6 h for 10 doses from 24 h after methotrexate start",{},"fixed",{"perDose":56,"dosesPerDay":57},15,4,[59],{"source":36,"section":60},"Dosage and Administration",[62],{"text":63,"refs":66},{"fa":64,"en":65},"تنظیم بر اساس کراتینین و سطح متوترکسات (جدول برچسب). هرگز داخل نخاعی. وریدی حداکثر ۱۶۰ mg\u002Fدقیقه (کلسیم).","Adjust by creatinine and methotrexate levels (label table). Never intrathecal. IV no faster than 160 mg\u002Fmin (calcium).",[67,68],{"source":36,"section":60},{"source":36,"section":69},"Warnings",{"id":71,"disease":72,"label":73,"population":76,"type":80,"unit":31,"dose":81,"refs":83,"durationDays":85,"notes":87},"crc","colorectal-cancer",{"fa":74,"en":75},"سرطان کولورکتال پیشرفته — ۲۰۰ mg\u002Fm² وریدی آهسته، سپس فلوئورویوراسیل ۳۷۰ mg\u002Fm²، روزانه ۵ روز","Advanced colorectal cancer — 200 mg\u002Fm² slow IV, then fluorouracil 370 mg\u002Fm², daily for 5 days",{"minAge":77},{"value":78,"unit":79},18,"year","bsa",{"perM2PerDay":82,"dividedDoses":5},200,[84],{"source":36,"section":60},{"min":86,"max":86},5,[88,94],{"text":89,"refs":92},{"fa":90,"en":91},"یا ۲۰ mg\u002Fm² سپس فلوئورویوراسیل ۴۲۵ mg\u002Fm². در یک انفوزیون با فلوئورویوراسیل مخلوط نشود.","Or 20 mg\u002Fm² then fluorouracil 425 mg\u002Fm². Do not mix with fluorouracil in one infusion.",[93],{"source":36,"section":60},{"text":95,"refs":98},{"fa":96,"en":97},"فقط زیر نظر پزشک متخصص انکولوژی؛ پروتکل، فاصله دوره‌ها و تنظیم با تیم درمان.","Only under an oncologist; protocol, cycle interval and adjustment rest with the treating team.",[99],{"source":36,"section":60},[101],{"id":102,"severity":103,"text":104,"refs":107},"ci","block",{"fa":105,"en":106},"کم‌خونی پرنیشیوز و سایر کم‌خونی‌های مگالوبلاستیک ناشی از کمبود B12.","Pernicious anaemia and other megaloblastic anaemias from vitamin B12 deficiency.",[108],{"source":36,"section":109},"Contraindications",[111],{"text":112,"refs":115},{"fa":113,"en":114},"داخل نخاعی کشنده است؛ هرچه زودتر پس از مسمومیت ضدفولات؛ با فلوئورویوراسیل سمیت بیشتر (به‌ویژه سالمند).","Fatal if given intrathecally; give as soon as possible after antifolate overdose; enhances fluorouracil toxicity (especially elderly).",[116],{"source":36,"section":69},[],[],[],{"status":121,"reviewer":122,"date":122},"unverified",null,[124,129],{"regimen":48,"formulation":25,"input":125,"expect":128},{"ageYears":126,"weightKg":127},30,70,{"perDose":56},{"regimen":71,"formulation":39,"input":130,"expect":134},{"ageYears":131,"weightKg":132,"heightCm":133},55,80,180,{"perDose":135},400,[137],"V03AF03",{"status":139,"forms":140,"refs":213},"registered",[141,145,149,153,157,161,165,169,173,177,181,185,189,193,197,201,205,209],{"code":142,"en":143,"fa":144},"21945","CALCIUM FOLINATE 1000MG\u002F100ML VIAL","ویال کلسیم فولینات ۱۰۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":146,"en":147,"fa":148},"16766","CALCIUM FOLINATE 100MG VIAL","ویال کلسیم فولینات ۱۰۰ میلی‌گرم",{"code":150,"en":151,"fa":152},"09570","CALCIUM FOLINATE 100MG\u002F10ML VIAL","ویال کلسیم فولینات ۱۰۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":154,"en":155,"fa":156},"11886","CALCIUM FOLINATE 10MG\u002FML 10ML AMP","آمپول کلسیم فولینات ۱۰ میلی‌گرم \u002F میلی‌لیتر ۱۰ میلی‌لیتر",{"code":158,"en":159,"fa":160},"11889","CALCIUM FOLINATE 10MG\u002FML 5ML AMP","آمپول کلسیم فولینات ۱۰ میلی‌گرم \u002F میلی‌لیتر ۵ میلی‌لیتر",{"code":162,"en":163,"fa":164},"00738","CALCIUM FOLINATE 15MG TAB","قرص کلسیم فولینات ۱۵ میلی‌گرم",{"code":166,"en":167,"fa":168},"09572","CALCIUM FOLINATE 200MG\u002F20ML VIAL","ویال کلسیم فولینات ۲۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":170,"en":171,"fa":172},"00739","CALCIUM FOLINATE 25MG TAB","قرص کلسیم فولینات ۲۵ میلی‌گرم",{"code":174,"en":175,"fa":176},"01567","CALCIUM FOLINATE 25MG\u002F5ML AMP","آمپول کلسیم فولینات ۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":178,"en":179,"fa":180},"02382","CALCIUM FOLINATE 30MG FOR INJ","فرآورده تزریقی کلسیم فولینات ۳۰ میلی‌گرم",{"code":182,"en":183,"fa":184},"10521","CALCIUM FOLINATE 30MG TAB","قرص کلسیم فولینات ۳۰ میلی‌گرم",{"code":186,"en":187,"fa":188},"00736","CALCIUM FOLINATE 30MG\u002F3ML AMP","آمپول کلسیم فولینات ۳۰ میلی‌گرم \u002F ۳ میلی‌لیتر",{"code":190,"en":191,"fa":192},"00737","CALCIUM FOLINATE 3MG\u002FML AMP","آمپول کلسیم فولینات ۳ میلی‌گرم \u002F میلی‌لیتر",{"code":194,"en":195,"fa":196},"09573","CALCIUM FOLINATE 400MG\u002F40ML VIAL","ویال کلسیم فولینات ۴۰۰ میلی‌گرم \u002F ۴۰ میلی‌لیتر",{"code":198,"en":199,"fa":200},"19476","CALCIUM FOLINATE 500MG\u002F50ML VIAL","ویال کلسیم فولینات ۵۰۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",{"code":202,"en":203,"fa":204},"00740","CALCIUM FOLINATE 5MG TAB","قرص کلسیم فولینات ۵ میلی‌گرم",{"code":206,"en":207,"fa":208},"21946","CALCIUM FOLINATE 800MG\u002F80ML VIAL","ویال کلسیم فولینات ۸۰۰ میلی‌گرم \u002F ۸۰ میلی‌لیتر",{"code":210,"en":211,"fa":212},"52936","CALCIUM FOLINATE INJECTION, POWDER PARENTERAL 200 mg","پودر تزریقی کلسیم فولینات ۲۰۰ میلی‌گرم",[214],{"source":215,"section":216,"url":217},"darooyab-generic","G-2883\u002FCalcium-Folinate","https:\u002F\u002Fwww.darooyab.ir\u002FG-2883\u002FCalcium-Folinate",[219,223,227,230,233,236],{"kind":220,"url":221,"label":222},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200753","ANDA200753",{"kind":224,"url":225,"label":226},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9d0e5356-ff39-4a8e-944c-e808a21ef4b2","FDA Leucovorin inj",{"kind":228,"url":229,"label":15},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682336.html",{"kind":228,"url":231,"label":232},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa608038.html","Leucovorin Injection",{"kind":234,"url":235,"label":137},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AF03",{"kind":237,"url":217,"label":238},"darooyab","Calcium-Folinate",{"pregnancy":240,"lactation":249,"pediatric":257,"geriatric":265},{"level":241,"text":242,"quote":245,"refs":246},"caution",{"fa":243,"en":244},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category C Adequate animal reproduction studies have not been conducted with leucovorin.",[247],{"source":36,"section":248},"Pregnancy",{"level":241,"text":250,"quote":253,"refs":254},{"fa":251,"en":252},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when leucovorin is administered to a nursing mother.",[255],{"source":36,"section":256},"Nursing Mothers",{"level":241,"text":258,"quote":261,"refs":262},{"fa":259,"en":260},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See PRECAUTIONS, Drug Interactions .",[263],{"source":36,"section":264},"Pediatric Use",{"level":241,"text":266,"quote":269,"refs":270},{"fa":267,"en":268},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elder patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[271],{"source":36,"section":272},"Geriatric Use",{"kind":274,"refs":275,"id":222},"ANDA",[276],{"source":36,"section":277},"SPL approval \u002F marketing category",1792444406920]