[{"data":1,"prerenderedAt":249},["ShallowReactive",2],{"drug-lenalidomide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":68,"contraindications":116,"warnings":126,"renal":134,"monitoring":144,"interactions":145,"review":146,"examples":149,"atc":158,"iran":160,"usApproval":184,"links":190,"populations":206},"lenalidomide",1,{"fa":7,"en":8},"لنالیدومید","Lenalidomide","antineoplastic-immunomodulating",{"fa":11,"en":12},"داروی تعدیل‌کننده ایمنی (مشتق تالیدومید)","Immunomodulatory drug (thalidomide analogue)",[14],{"name":15,"market":16},"Revlimid","US",[18,19,20],"revlimid","رولیمید","لنالیدوماید",[22,36,44,52,60],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"cap-25","capsule","oral","25 mg capsule",{"amount":28,"unit":29,"perUnit":24,"scored":30},25,"mg",false,[16],[33],{"source":34,"section":35},"fda-revlimid","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"cap-10","10 mg capsule",{"amount":40,"unit":29,"perUnit":24,"scored":30},10,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"cap-5","5 mg capsule",{"amount":48,"unit":29,"perUnit":24,"scored":30},5,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"cap-15","15 mg capsule",{"amount":56,"unit":29,"perUnit":24,"scored":30},15,[16],[59],{"source":34,"section":35},{"id":61,"form":24,"route":25,"label":62,"concentration":63,"markets":65,"refs":66},"cap-20","20 mg capsule",{"amount":64,"unit":29,"perUnit":24,"scored":30},20,[16],[67],{"source":34,"section":35},[69,103],{"id":70,"disease":71,"label":72,"population":75,"type":79,"unit":29,"dose":80,"refs":81,"allowedFormulations":84,"notes":85},"mm","multiple-myeloma",{"fa":73,"en":74},"مولتیپل میلوما (ترکیبی) — ۲۵ mg یک بار روزهای ۱ تا ۲۱ هر دوره ۲۸ روزه","Multiple myeloma (combination) — 25 mg once daily on days 1–21 of 28-day cycles",{"minAge":76},{"value":77,"unit":78},18,"year","fixed",{"perDose":28,"dosesPerDay":5},[82],{"source":34,"section":83},"2.1",[23],[86,96],{"text":87,"refs":90},{"fa":88,"en":89},"نگهدارنده پس از پیوند: ۱۰ mg روزانه مداوم. کپسول باز یا جویده نشود. فقط از طریق برنامه REMS.","Maintenance after auto-HSCT: 10 mg daily continuously. Do not open or chew. Only through the REMS programme.",[91,92,94],{"source":34,"section":83},{"source":34,"section":93},"2.7",{"source":34,"section":95},"5.2",{"text":97,"refs":100},{"fa":98,"en":99},"فقط زیر نظر پزشک متخصص انکولوژی؛ پروتکل، فاصله دوره‌ها و تنظیم با تیم درمان.","Only under an oncologist; protocol, cycle interval and adjustment rest with the treating team.",[101],{"source":34,"section":102},"2",{"id":104,"disease":105,"label":106,"population":109,"type":79,"unit":29,"dose":111,"refs":112,"allowedFormulations":115},"mds","myelodysplastic-syndrome",{"fa":107,"en":108},"سندرم میلودیسپلاستیک (del 5q) — ۱۰ mg یک بار در روز","Myelodysplastic syndrome (del 5q) — 10 mg once daily",{"minAge":110},{"value":77,"unit":78},{"perDose":40,"dosesPerDay":5},[113],{"source":34,"section":114},"2.2",[37],[117],{"id":118,"severity":119,"text":120,"refs":123},"ci","block",{"fa":121,"en":122},"بارداری؛ حساسیت شدید به لنالیدومید (آنژیوادم، SJS، TEN).","Pregnancy; severe hypersensitivity to lenalidomide (angioedema, SJS, TEN).",[124],{"source":34,"section":125},"4",[127],{"text":128,"refs":131},{"fa":129,"en":130},"هشدار جعبه‌ای: سمیت جنینی (دو تست بارداری منفی و دو روش پیشگیری)، سمیت خونی (نوتروپنی، ترومبوسیتوپنی)، ترومبوآمبولی وریدی و شریانی.","Boxed warning: embryo-fetal toxicity (two negative pregnancy tests and two contraceptive methods), haematologic toxicity (neutropenia, thrombocytopenia), venous and arterial thromboembolism.",[132],{"source":34,"section":133},"Boxed Warning",[135],{"egfrBelow":136,"severity":137,"text":138,"refs":141},60,"warn",{"fa":139,"en":140},"ClCr ۳۰ تا ۶۰: ۱۰ mg (نگهدارنده\u002FMDS: ۵ mg)؛ زیر ۳۰: طبق جدول ۳.","CrCl 30–60: 10 mg (maintenance\u002FMDS: 5 mg); below 30: per Table 3.",[142],{"source":34,"section":143},"2.6, Table 3",[],[],{"status":147,"reviewer":148,"date":148},"unverified",null,[150,154],{"regimen":70,"formulation":23,"input":151,"expect":153},{"ageYears":136,"weightKg":152},75,{"perDose":28,"tabletsPerDoseRounded":5},{"regimen":104,"formulation":37,"input":155,"expect":157},{"ageYears":156,"weightKg":156},70,{"perDose":40,"tabletsPerDoseRounded":5},[159],"L04AX04",{"status":161,"forms":162,"refs":179},"registered",[163,167,171,175],{"code":164,"en":165,"fa":166},"18193","LENALIDOMIDE 10 MG  CAP.","کپسول لنالیدوماید ۱۰ میلی‌گرم .",{"code":168,"en":169,"fa":170},"12847","LENALIDOMIDE 25MG  CAP","کپسول لنالیدوماید ۲۵ میلی‌گرم",{"code":172,"en":173,"fa":174},"50392","LENALIDOMIDE 15MG CAP","کپسول لنالیدوماید ۱۵ میلی‌گرم",{"code":176,"en":177,"fa":178},"51479","LENALIDOMIDE 5MG CAP","کپسول لنالیدوماید ۵ میلی‌گرم",[180],{"source":181,"section":182,"url":183},"darooyab-generic","G-4686\u002FLenalidomide","https:\u002F\u002Fwww.darooyab.ir\u002FG-4686\u002FLenalidomide",{"kind":185,"refs":186,"id":189},"NDA",[187],{"source":34,"section":188},"SPL approval \u002F marketing category","NDA021880",[191,194,198,201,204],{"kind":192,"url":193,"label":189},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021880",{"kind":195,"url":196,"label":197},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=5fa97bf5-28a2-48f1-8955-f56012d296be","FDA Revlimid",{"kind":199,"url":200,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa608001.html",{"kind":202,"url":203,"label":159},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L04AX04",{"kind":205,"url":183,"label":8},"darooyab",{"pregnancy":207,"lactation":215,"pediatric":224,"geriatric":233,"reproductive":241},{"level":208,"text":209,"quote":212,"refs":213},"contraindicated",{"fa":210,"en":211},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Due to the results of this developmental monkey study, and lenalidomide's structural similarities to thalidomide, a known human teratogen, lenalidomide is contraindicated in females who are pregnant [see Boxed Warning ].",[214],{"source":34,"section":125},{"level":216,"text":217,"quote":220,"refs":221},"avoid",{"fa":218,"en":219},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for adverse reactions in breastfed children from REVLIMID, advise women not to breastfeed during treatment with REVLIMID.",[222],{"source":34,"section":223},"8.2",{"level":225,"text":226,"quote":229,"refs":230},"caution",{"fa":227,"en":228},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness have not been established in pediatric patients.",[231],{"source":34,"section":232},"8.4",{"level":225,"text":234,"quote":237,"refs":238},{"fa":235,"en":236},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Since elderly patients are more likely to have decreased renal function, care should be taken in dose selection.",[239],{"source":34,"section":240},"8.5",{"level":225,"text":242,"quote":245,"refs":246},{"fa":243,"en":244},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Females of reproductive potential must commit either to abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control simultaneously: one highly effective form of contraception – tubal ligation, IUD, hormonal (birth control pills, injections, hormonal …",[247],{"source":34,"section":248},"8.3",1792444406809]