[{"data":1,"prerenderedAt":181},["ShallowReactive",2],{"drug-imipramine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":54,"contraindications":128,"warnings":159,"renal":160,"monitoring":161,"interactions":162,"review":163,"examples":166},"imipramine",1,{"fa":7,"en":8},"ایمی‌پرامین","Imipramine","psychiatry",{"fa":11,"en":12},"ضدافسردگی سه‌حلقه‌ای","Tricyclic antidepressant",[14],{"name":15,"market":16},"Tofranil","US",[18,19,20,21,22],"tofranil","توفرانیل","ایمی پرامین","ایمیپرامین","شب ادراری",[24,38,46],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-10","tablet","oral","10 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},10,"mg",false,[16],[35],{"source":36,"section":37},"fda-imipramine","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"tab-25","25 mg tablet",{"amount":42,"unit":31,"perUnit":26,"scored":32},25,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"tab-50","50 mg tablet",{"amount":50,"unit":31,"perUnit":26,"scored":32},50,[16],[53],{"source":36,"section":37},[55,81,106],{"id":56,"disease":56,"label":57,"population":60,"type":64,"unit":31,"dose":65,"refs":67,"limits":70,"notes":74},"mdd",{"fa":58,"en":59},"افسردگی — بزرگسال سرپایی: ۷۵ mg\u002Fday (تا ۱۵۰)","Depression — adult outpatients: 75 mg\u002Fday (up to 150)",{"minAge":61},{"value":62,"unit":63},18,"year","fixed",{"perDose":42,"dosesPerDay":66},3,[68],{"source":36,"section":69},"Dosage and Administration",{"maxPerDay":71,"refs":72},200,[73],{"source":36,"section":69},[75],{"text":76,"refs":79},{"fa":77,"en":78},"بستری: ۱۰۰ mg\u002Fday تا ۲۰۰؛ بالای ۲۰۰ mg\u002Fday توصیه نمی‌شود (جز بستری‌های مقاوم). نگهدارنده ۵۰ تا ۱۵۰ mg\u002Fday.","Inpatients: 100 mg\u002Fday up to 200; over 200 mg\u002Fday not recommended (except resistant inpatients). Maintenance 50–150 mg\u002Fday.",[80],{"source":36,"section":69},{"id":82,"disease":83,"label":84,"population":87,"type":64,"unit":31,"dose":92,"refs":93,"limits":95,"notes":99},"enuresis-6-11","nocturnal-enuresis",{"fa":85,"en":86},"شب‌ادراری — ۶ تا ۱۱ سال: ۲۵ mg یک ساعت قبل از خواب","Enuresis — 6–11 y: 25 mg one hour before bedtime",{"minAge":88,"maxAge":90},{"value":89,"unit":63},6,{"value":91,"unit":63},12,{"perDose":42,"dosesPerDay":5},[94],{"source":36,"section":69},{"maxPerKgPerDay":96,"refs":97},2.5,[98],{"source":36,"section":69},[100],{"text":101,"refs":104},{"fa":102,"en":103},"اگر پس از یک هفته پاسخ نبود ۵۰ mg شبانه. بیش از ۲٫۵ mg\u002Fkg\u002Fday نشود.","If no response after one week, 50 mg nightly. Do not exceed 2.5 mg\u002Fkg\u002Fday.",[105],{"source":36,"section":69},{"id":107,"disease":83,"label":108,"population":111,"type":64,"unit":31,"dose":114,"refs":115,"limits":117,"notes":121},"enuresis-12",{"fa":109,"en":110},"شب‌ادراری — ۱۲ سال به بالا: ۲۵ mg قبل از خواب","Enuresis — ≥12 y: 25 mg before bedtime",{"minAge":112,"maxAge":113},{"value":91,"unit":63},{"value":62,"unit":63},{"perDose":42,"dosesPerDay":5},[116],{"source":36,"section":69},{"maxPerKgPerDay":96,"maxPerDay":118,"refs":119},75,[120],{"source":36,"section":69},[122],{"text":123,"refs":126},{"fa":124,"en":125},"در صورت نیاز تا ۷۵ mg شبانه؛ بالاتر اثر بیشتری ندارد.","Up to 75 mg nightly if needed; higher adds no efficacy.",[127],{"source":36,"section":69},[129,138,148],{"id":130,"severity":131,"text":132,"refs":135},"ci","block",{"fa":133,"en":134},"همراه MAOI؛ دوره بهبود حاد پس از MI.","With MAOIs; acute recovery period after MI.",[136],{"source":36,"section":137},"Contraindications",{"id":139,"severity":131,"rule":140,"text":142,"refs":145},"under-6",{"maxAge":141},{"value":89,"unit":63},{"fa":143,"en":144},"زیر ۶ سال ثابت نشده.","Not established under 6 years.",[146],{"source":36,"section":147},"Pediatric Use",{"id":149,"severity":150,"rule":151,"text":153,"refs":156},"suicide","warn",{"maxAge":152},{"value":42,"unit":63},{"fa":154,"en":155},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[157],{"source":36,"section":158},"Boxed Warning",[],[],[],[],{"status":164,"reviewer":165,"date":165},"unverified",null,[167,172,176],{"regimen":56,"formulation":39,"input":168,"expect":171},{"ageYears":169,"weightKg":170},40,70,{"perDose":42,"perDay":118},{"regimen":82,"formulation":39,"input":173,"expect":175},{"ageYears":174,"weightKg":42},8,{"perDose":42},{"regimen":107,"formulation":39,"input":177,"expect":180},{"ageYears":178,"weightKg":179},13,45,{"perDose":42},1792078536315]