[{"data":1,"prerenderedAt":141},["ShallowReactive",2],{"drug-hydroxocobalamin-cyanokit":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":62,"warnings":63,"renal":64,"monitoring":65,"interactions":66,"review":67,"examples":70,"atc":76,"iran":78,"links":85,"populations":101,"usApproval":136},"hydroxocobalamin-cyanokit",1,{"fa":7,"en":8},"هیدروکسوکوبالامین (سیانوکیت)","Hydroxocobalamin (Cyanokit)","various",{"fa":11,"en":12},"پادزهر سیانید","Cyanide antidote",[14],{"name":15,"market":16},"Cyanokit","US",[18,19,20],"cyanokit","سیانوکیت","پادزهر سیانور",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"vial-5g","powder-for-injection","iv","5 g vial (reconstitute with 200 mL; 25 mg\u002FmL)",{"amount":28,"unit":29,"perUnit":30},5000,"mg","vial",[16],[33],{"source":34,"section":35},"fda-cyanokit","3",[37],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":29,"dose":48,"refs":49,"durationDays":52,"notes":53},"adult","cyanide-poisoning",{"fa":41,"en":42},"مسمومیت با سیانید — بزرگسال: ۵ g وریدی در ۱۵ دقیقه","Cyanide poisoning — adult: 5 g IV over 15 min",{"minAge":44},{"value":45,"unit":46},18,"year","fixed",{"perDose":28,"dosesPerDay":5},[50],{"source":34,"section":51},"2.2",{"min":5,"max":5},[54],{"text":55,"refs":58},{"fa":56,"en":57},"در صورت شک بالا بی‌درنگ. بسته به شدت، دوز دوم ۵ g (مجموع ۱۰ g) در ۱۵ دقیقه تا ۲ ساعت. حمایت راه هوایی، اکسیژن و گردش خون نباید به تأخیر بیفتد.","Give without delay if suspicion is high. Depending on severity, a second 5 g dose (total 10 g) over 15 min to 2 h. Do not delay airway, oxygen and circulatory support.",[59,60],{"source":34,"section":51},{"source":34,"section":61},"2.1",[],[],[],[],[],{"status":68,"reviewer":69,"date":69},"unverified",null,[71],{"regimen":38,"formulation":23,"input":72,"expect":75},{"ageYears":73,"weightKg":74},40,70,{"perDose":28},[77],"V03AB33",{"status":79,"refs":80},"not-found",[81],{"source":82,"section":83,"url":84},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Hydroxocobalamin",[86,90,94,98],{"kind":87,"url":88,"label":89},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=022041","NDA022041",{"kind":91,"url":92,"label":93},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=d56fcc8d-bd64-46ab-b0c0-2124bd745a6b","FDA Cyanokit",{"kind":95,"url":96,"label":97},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605007.html","Cyanocobalamin Injection",{"kind":99,"url":100,"label":77},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB33",{"pregnancy":102,"lactation":111,"pediatric":120,"geriatric":128},{"level":103,"text":104,"quote":107,"refs":108},"caution",{"fa":105,"en":106},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from cases reported in the published literature and postmarketing surveillance with CYANOKIT use in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal and fetal outcomes.",[109],{"source":34,"section":110},"8.1",{"level":112,"text":113,"quote":116,"refs":117},"avoid",{"fa":114,"en":115},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Risk Summary Breastfeeding is not recommended during treatment with CYANOKIT.",[118],{"source":34,"section":119},"8.2",{"level":103,"text":121,"quote":124,"refs":125},{"fa":122,"en":123},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness of CYANOKIT have not been established in this population.",[126],{"source":34,"section":127},"8.4",{"level":103,"text":129,"quote":132,"refs":133},{"fa":130,"en":131},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Approximately 50 known or suspected cyanide poisoning victims aged 65 or older received hydroxocobalamin in clinical studies.",[134],{"source":34,"section":135},"8.5",{"kind":137,"refs":138,"id":89},"NDA",[139],{"source":34,"section":140},"SPL approval \u002F marketing category",1792108425572]