[{"data":1,"prerenderedAt":176},["ShallowReactive",2],{"drug-granisetron":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":33,"contraindications":56,"warnings":66,"renal":74,"monitoring":75,"interactions":76,"review":77,"examples":80,"atc":86,"iran":88,"links":116,"populations":136,"usApproval":171},"granisetron",1,{"fa":7,"en":8},"گرانیسترون","Granisetron","alimentary-metabolism",{"fa":11,"en":12},"آنتاگونیست 5-HT3 (ضدتهوع)","5-HT3 antagonist (antiemetic)",[14],{"name":15,"market":16},"Kytril","US",[18,7],"kytril",[20],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":28,"refs":29},"tab-1","tablet","oral","1 mg tablet",{"amount":5,"unit":26,"perUnit":22,"scored":27},"mg",false,[16],[30],{"source":31,"section":32},"fda-granisetron","How Supplied",[34],{"id":35,"disease":35,"label":36,"population":39,"type":43,"unit":26,"dose":44,"refs":46,"notes":49},"cinv",{"fa":37,"en":38},"پیشگیری از تهوع شیمی‌درمانی — ۲ mg یک بار (یا ۱ mg دو بار) فقط در روز شیمی‌درمانی","Chemotherapy nausea prevention — 2 mg once (or 1 mg twice) on chemotherapy days only",{"minAge":40},{"value":41,"unit":42},18,"year","fixed",{"perDose":45,"dosesPerDay":5},2,[47],{"source":31,"section":48},"Dosage and Administration",[50],{"text":51,"refs":54},{"fa":52,"en":53},"تا ۱ ساعت پیش از شیمی‌درمانی. رژیم دیگر: ۱ mg تا ۱ ساعت قبل و ۱ mg دوم ۱۲ ساعت بعد.","Up to 1 h before chemotherapy. Alternative: 1 mg up to 1 h before and a second 1 mg 12 h later.",[55],{"source":31,"section":48},[57],{"id":58,"severity":59,"text":60,"refs":63},"hyper","block",{"fa":61,"en":62},"حساسیت به گرانیسترون یا اجزای فرآورده.","Hypersensitivity to granisetron or its components.",[64],{"source":31,"section":65},"Contraindications",[67],{"text":68,"refs":71},{"fa":69,"en":70},"سندرم سروتونین با داروهای سروتونرژیک.","Serotonin syndrome with serotonergic drugs.",[72],{"source":31,"section":73},"Warnings",[],[],[],{"status":78,"reviewer":79,"date":79},"unverified",null,[81],{"regimen":35,"formulation":21,"input":82,"expect":85},{"ageYears":83,"weightKg":84},50,70,{"perDose":45,"tabletsPerDoseRounded":45},[87],"A04AA02",{"status":89,"forms":90,"refs":111},"registered",[91,95,99,103,107],{"code":92,"en":93,"fa":94},"05170","GRANISETRON 1MG\u002F1ML AMP","آمپول گرانیسترون ۱ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":96,"en":97,"fa":98},"08870","GRANISETRON 3MG\u002F3ML AMP","آمپول گرانیسترون ۳ میلی‌گرم \u002F ۳ میلی‌لیتر",{"code":100,"en":101,"fa":102},"00609","GRANISETRON HCL 1MG TAB","قرص گرانیسترون هیدروکلراید ۱ میلی‌گرم",{"code":104,"en":105,"fa":106},"00610","GRANISETRON HCL 3MG\u002F3ML VIAL","ویال گرانیسترون هیدروکلراید ۳ میلی‌گرم \u002F ۳ میلی‌لیتر",{"code":108,"en":109,"fa":110},"21313","GRANISETRON PATCH, EXTENDED RELEASE TRANSDERMAL 34.3 mg\u002F52cm2","پچ پوستی گرانیسترون ۳۴٫۳ میلی‌گرم \u002F ۵۲ سانتی‌متر ۲",[112],{"source":113,"section":114,"url":115},"darooyab-generic","G-2590\u002FGranisetron","https:\u002F\u002Fwww.darooyab.ir\u002FG-2590\u002FGranisetron",[117,121,125,128,131,134],{"kind":118,"url":119,"label":120},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078969","ANDA078969",{"kind":122,"url":123,"label":124},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=df4b6775-4337-41e0-815a-b064d98c3fe1","FDA Granisetron tab",{"kind":126,"url":127,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601211.html",{"kind":126,"url":129,"label":130},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa694011.html","Granisetron Injection",{"kind":132,"url":133,"label":87},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A04AA02",{"kind":135,"url":115,"label":8},"darooyab",{"pregnancy":137,"lactation":146,"pediatric":154,"geriatric":163},{"level":138,"text":139,"quote":142,"refs":143},"caution",{"fa":140,"en":141},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category B Reproduction studies have been performed in pregnant rats at oral doses up to 125 mg\u002Fkg\u002Fday (750 mg\u002Fm 2 \u002Fday, 507 times the recommended human dose based on body surface area) and pregnant rabbits at oral doses up to 32 mg\u002Fkg\u002Fday (378 mg\u002Fm 2 \u002Fday, 255 times the recommended human …",[144],{"source":31,"section":145},"Pregnancy",{"level":138,"text":147,"quote":150,"refs":151},{"fa":148,"en":149},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when granisetron hydrochloride is administered to a nursing woman.",[152],{"source":31,"section":153},"Nursing Mothers",{"level":155,"text":156,"quote":159,"refs":160},"not-established",{"fa":157,"en":158},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[161],{"source":31,"section":162},"Pediatric Use",{"level":138,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","During clinical trials, 325 patients 65 years of age or older received granisetron hydrochloride tablets; 298 were 65 to 74 years of age, and 27 were 75 years of age or older.",[169],{"source":31,"section":170},"Geriatric Use",{"kind":172,"refs":173,"id":120},"ANDA",[174],{"source":31,"section":175},"SPL approval \u002F marketing category",1792115182175]