[{"data":1,"prerenderedAt":154},["ShallowReactive",2],{"drug-gliclazide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":19,"formulations":25,"regimens":51,"contraindications":116,"warnings":127,"renal":135,"monitoring":136,"interactions":137,"review":138,"examples":141},"gliclazide",1,{"fa":7,"en":8},"گلی‌کلازید","Gliclazide","endocrine",{"fa":11,"en":12},"سولفونیل‌اوره","Sulfonylurea",[14,17],{"name":15,"market":16},"Diamicron","GB",{"name":18,"market":16},"Diamicron MR",[20,21,22,23,24],"diamicron","دیامیکرون","گلیکلازید","گلی کلازید","sulfonylurea",[26,40],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"tab-80","tablet","oral","80 mg tablet (cross-scored)",{"amount":32,"unit":33,"perUnit":28,"scored":34},80,"mg",true,[16],[37],{"source":38,"section":39},"uk-smpc-diamicron-80","3",{"id":41,"form":28,"route":29,"label":42,"concentration":43,"markets":46,"refs":47},"mr-30","30 mg modified-release tablet",{"amount":44,"unit":33,"perUnit":28,"scored":45},30,false,[16],[48],{"source":49,"section":50},"uk-smpc-gliclazide-mr-30","2",[52,80,102],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":33,"dose":63,"refs":65,"limits":68,"notes":73},"ir","type-2-diabetes",{"fa":56,"en":57},"دیابت نوع ۲ — قرص ۸۰ mg معمولی: شروع ۴۰ تا ۸۰ mg\u002Fday","Type 2 diabetes — 80 mg IR tablet: start 40–80 mg\u002Fday",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":64,"perDoseMax":32,"dosesPerDay":5},40,[66],{"source":38,"section":67},"4.2",{"maxPerDose":69,"maxPerDay":70,"refs":71},160,320,[72],{"source":38,"section":67},[74],{"text":75,"refs":78},{"fa":76,"en":77},"افزایش تا کنترل کافی؛ کل روزانه ۴۰ تا ۳۲۰ mg. تک‌دوز بیش از ۱۶۰ mg نباشد؛ دوزهای بالاتر دو بار در روز همراه وعده‌های اصلی.","Increase until controlled; total 40–320 mg\u002Fday. A single dose must not exceed 160 mg; higher doses twice daily with main meals.",[79],{"source":38,"section":67},{"id":81,"disease":54,"label":82,"population":85,"type":62,"unit":33,"dose":87,"refs":88,"limits":90,"allowedFormulations":94,"notes":95},"mr",{"fa":83,"en":84},"دیابت نوع ۲ — آهسته‌رهش (MR): شروع ۳۰ mg صبح","Type 2 diabetes — modified release (MR): start 30 mg at breakfast",{"minAge":86},{"value":60,"unit":61},{"perDose":44,"dosesPerDay":5},[89],{"source":49,"section":67},{"maxPerDay":91,"refs":92},120,[93],{"source":49,"section":67},[41],[96],{"text":97,"refs":100},{"fa":98,"en":99},"یک بار با صبحانه. در صورت نیاز ۶۰، ۹۰ یا ۱۲۰ mg با فاصله حداقل ۱ ماه (یا ۲ هفته اگر قند پایین نیامده). قرص MR جویده یا خرد نشود. یک قرص ۸۰ mg معمولی ≈ یک قرص ۳۰ mg MR.","Once with breakfast. If needed 60, 90 or 120 mg at ≥1-month steps (2 weeks if no fall in glucose). Do not chew or crush. One 80 mg IR tablet ≈ one 30 mg MR tablet.",[101],{"source":49,"section":67},{"id":103,"disease":54,"label":104,"population":107,"type":109,"unit":33,"dose":110,"refs":114},"peds",{"fa":105,"en":106},"زیر ۱۸ سال","Under 18 years",{"maxAge":108},{"value":60,"unit":61},"notCalculated",{"reason":111},{"fa":112,"en":113},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in children not established.",[115],{"source":49,"section":67},[117],{"id":118,"severity":119,"text":120,"refs":123},"ci","block",{"fa":121,"en":122},"حساسیت به گلی‌کلازید، سایر سولفونیل‌اوره‌ها یا سولفونامیدها؛ دیابت نوع ۱؛ کتواسیدوز یا کمای دیابتی؛ نارسایی شدید کلیه یا کبد؛ مصرف میکونازول؛ شیردهی.","Hypersensitivity to gliclazide, other sulfonylureas or sulfonamides; type 1 diabetes; diabetic ketoacidosis or coma; severe renal or hepatic insufficiency; miconazole; lactation.",[124,126],{"source":38,"section":125},"4.3",{"source":49,"section":125},[128],{"text":129,"refs":132},{"fa":130,"en":131},"خطر هیپوگلیسمی؛ وعده غذایی منظم لازم است.","Risk of hypoglycaemia; regular meals needed.",[133],{"source":38,"section":134},"4.4",[],[],[],{"status":139,"reviewer":140,"date":140},"unverified",null,[142,147,150],{"regimen":53,"formulation":27,"input":143,"expect":145},{"ageYears":144,"weightKg":32},55,{"perDose":64,"tabletsPerDoseRounded":146,"upperPerDose":32},0.5,{"regimen":81,"formulation":41,"input":148,"expect":149},{"ageYears":144,"weightKg":32},{"perDose":44},{"regimen":81,"formulation":27,"input":151,"expect":152},{"ageYears":144,"weightKg":32},{"status":153},"blocked",1792078535791]