[{"data":1,"prerenderedAt":167},["ShallowReactive",2],{"drug-fosphenytoin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":62,"warnings":72,"renal":80,"monitoring":81,"interactions":82,"review":83,"examples":86,"atc":100,"iran":102,"links":109,"populations":128,"usApproval":162},"fosphenytoin",1,{"fa":7,"en":8},"فوس‌فنی‌توئین (تزریقی)","Fosphenytoin (injection)","nervous-system",{"fa":11,"en":12},"ضدتشنج (پیش‌داروی فنی‌توئین)","Anticonvulsant (phenytoin prodrug)",[14],{"name":15,"market":16},"Cerebyx","US",[18,19,20],"cerebyx","سربیکس","فوس فنی توئین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"vial-50","injection","iv","50 mg PE\u002FmL (100 mg PE\u002F2 mL; 500 mg PE\u002F10 mL)",{"amount":28,"unit":29,"perVolumeMl":5},50,"mg",[16],[32],{"source":33,"section":34},"fda-cerebyx","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":43,"unit":29,"dose":44,"refs":47,"durationDays":52,"notes":53},"se","status-epilepticus",{"fa":40,"en":41},"صرع پایدار — دوز بارگذاری ۱۵ تا ۲۰ mg PE\u002Fkg (بزرگسال و کودک)","Status epilepticus — loading dose 15–20 mg PE\u002Fkg (adults and children)",{},"weightBased",{"perKgPerDay":45,"perKgPerDayMax":46,"dividedDoses":5},15,20,[48,50],{"source":33,"section":49},"2.3",{"source":33,"section":51},"Highlights — Dosage and Administration",{"min":5,"max":5},[54],{"text":55,"refs":58},{"fa":56,"en":57},"همه دوزها بر حسب «معادل فنی‌توئین سدیم» (PE). سرعت: بزرگسال ۱۰۰ تا ۱۵۰ mg PE\u002Fmin (حداکثر ۱۵۰)؛ کودک ۲ mg PE\u002Fkg\u002Fmin یا ۱۵۰ mg PE\u002Fmin هر کدام کندتر. پیش از انفوزیون تا ۱٫۵ تا ۲۵ mg PE\u002FmL رقیق شود. پایش مداوم ECG، فشار و تنفس. معمولاً همراه بنزودیازپین وریدی؛ سپس دوز نگهدارنده.","All doses in phenytoin sodium equivalents (PE). Rate: adults 100–150 mg PE\u002Fmin (max 150); children 2 mg PE\u002Fkg\u002Fmin or 150 mg PE\u002Fmin, whichever is slower. Dilute to 1.5–25 mg PE\u002FmL before infusion. Continuous ECG, BP and respiratory monitoring. Usually with an IV benzodiazepine; follow with maintenance dosing.",[59,60],{"source":33,"section":49},{"source":33,"section":61},"2.2",[63],{"id":64,"severity":65,"text":66,"refs":69},"ci","block",{"fa":67,"en":68},"حساسیت به فوس‌فنی‌توئین، فنی‌توئین یا هیدانتوئین‌ها؛ برادی‌کاردی سینوسی، بلوک SA، بلوک AV درجه ۲ و ۳، سندرم آدامز-استوکس؛ سابقه سمیت کبدی با فنی‌توئین؛ مصرف همزمان دلاویردین.","Hypersensitivity to fosphenytoin, phenytoin or hydantoins; sinus bradycardia, SA block, 2nd\u002F3rd-degree AV block, Adams-Stokes syndrome; prior phenytoin hepatotoxicity; coadministration with delavirdine.",[70],{"source":33,"section":71},"4",[73],{"text":74,"refs":77},{"fa":75,"en":76},"هشدار جعبه‌ای: انفوزیون سریع خطر افت شدید فشار و آریتمی دارد؛ از سرعت مجاز تجاوز نشود.","Boxed warning: rapid infusion risks severe hypotension and arrhythmias; do not exceed the rate limits.",[78],{"source":33,"section":79},"Boxed Warning",[],[],[],{"status":84,"reviewer":85,"date":85},"unverified",null,[87,94],{"regimen":37,"formulation":23,"input":88,"expect":91},{"ageYears":89,"weightKg":90},40,70,{"perDose":92,"upperPerDose":93},1050,1400,{"regimen":37,"formulation":23,"input":95,"expect":97},{"ageYears":96,"weightKg":46},6,{"perDose":98,"upperPerDose":99},300,400,[101],"N03AB05",{"status":103,"refs":104},"not-found",[105],{"source":106,"section":107,"url":108},"darooyab-generic","G-666\u002FFosphenytoin","https:\u002F\u002Fwww.darooyab.ir\u002FG-666\u002FFosphenytoin",[110,114,118,122,125],{"kind":111,"url":112,"label":113},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020450","NDA020450",{"kind":115,"url":116,"label":117},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=d4c36fad-0ba2-4cd4-9c5e-dcf843f38a5a","FDA Cerebyx",{"kind":119,"url":120,"label":121},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa619063.html","Fosphenytoin Injection",{"kind":123,"url":124,"label":101},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AB05",{"kind":126,"url":108,"label":127},"darooyab","Fosphenytoin",{"pregnancy":129,"lactation":138,"pediatric":146,"geriatric":154},{"level":130,"text":131,"quote":134,"refs":135},"caution",{"fa":132,"en":133},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary In humans, prenatal exposure to phenytoin (the active metabolite of CEREBYX) may increase the risks for congenital malformations and other adverse developmental outcomes.",[136],{"source":33,"section":137},"8.1",{"level":130,"text":139,"quote":142,"refs":143},{"fa":140,"en":141},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Following administration of phenytoin (the active metabolite of CEREBYX), phenytoin is secreted in human milk.",[144],{"source":33,"section":145},"8.2",{"level":130,"text":147,"quote":150,"refs":151},{"fa":148,"en":149},"برچسب: برای همه گروه‌های سنی کودکان اندیکاسیون دارد؛ سرعت انفوزیون در کودک حداکثر ۲ mg PE\u002Fkg\u002Fmin یا ۱۵۰ mg PE\u002Fmin (هر کدام کندتر).","Label: indicated in all pediatric age groups; pediatric infusion rate max 2 mg PE\u002Fkg\u002Fmin or 150 mg PE\u002Fmin, whichever is slower.","CEREBYX is indicated for the treatment of generalized tonic-clonic status epilepticus and prevention and treatment of seizures occurring during neurosurgery in all pediatric age groups",[152],{"source":33,"section":153},"8.4",{"level":130,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","No systematic studies in geriatric patients have been conducted.",[160],{"source":33,"section":161},"8.5",{"kind":163,"refs":164,"id":113},"NDA",[165],{"source":33,"section":166},"SPL approval \u002F marketing category",1792108424145]