[{"data":1,"prerenderedAt":158},["ShallowReactive",2],{"drug-fomepizole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":61,"warnings":71,"renal":72,"monitoring":73,"interactions":74,"review":75,"examples":78,"atc":86,"iran":88,"links":104,"populations":118,"usApproval":153},"fomepizole",1,{"fa":7,"en":8},"فومپیزول","Fomepizole","various",{"fa":11,"en":12},"مهارکننده الکل دهیدروژناز (پادزهر)","Alcohol dehydrogenase inhibitor (antidote)",[14],{"name":15,"market":16},"Antizol","US",[18,7,19],"antizol","پادزهر متانول",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-1g","injection","iv","1 g\u002FmL (1.5 g\u002F1.5 mL) vial — dilute before infusion",{"amount":27,"unit":28,"perVolumeMl":5},1000,"mg",[16],[31],{"source":32,"section":33},"fda-fomepizole","How Supplied",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":49,"notes":52},"std","toxic-alcohol",{"fa":39,"en":40},"متانول یا اتیلن گلیکول — بارگذاری ۱۵ mg\u002Fkg، سپس ۱۰ mg\u002Fkg هر ۱۲ ساعت","Methanol or ethylene glycol — load 15 mg\u002Fkg, then 10 mg\u002Fkg every 12 h",{"minAge":42},{"value":43,"unit":44},18,"year","weightBased",{"perKgPerDose":47,"intervalHours":48},10,12,[50],{"source":32,"section":51},"Dosage and Administration",[53],{"text":54,"refs":57},{"fa":55,"en":56},"دوز اول ۱۵ mg\u002Fkg؛ سپس ۱۰ mg\u002Fkg هر ۱۲ ساعت برای ۴ دوز؛ سپس ۱۵ mg\u002Fkg هر ۱۲ ساعت تا سطح متانول یا اتیلن گلیکول غیرقابل‌اندازه‌گیری یا زیر ۲۰ mg\u002FdL، بیمار بی‌علامت و pH طبیعی. هر دوز انفوزیون ۳۰ دقیقه‌ای. در همودیالیز هر ۴ ساعت. سرنگ پلی‌کربنات مصرف نشود. ایمنی در کودکان ثابت نشده.","First dose 15 mg\u002Fkg; then 10 mg\u002Fkg every 12 h for 4 doses; then 15 mg\u002Fkg every 12 h until methanol or ethylene glycol is undetectable or \u003C20 mg\u002FdL, the patient is asymptomatic and pH normal. Each dose over 30 min. Every 4 h during haemodialysis. Do not use polycarbonate syringes. Safety in children not established.",[58,59],{"source":32,"section":51},{"source":32,"section":60},"Pediatric Use",[62],{"id":63,"severity":64,"text":65,"refs":68},"hyper","block",{"fa":66,"en":67},"حساسیت جدی به فومپیزول یا سایر پیرازول‌ها.","Serious hypersensitivity to fomepizole or other pyrazoles.",[69],{"source":32,"section":70},"Contraindications",[],[],[],[],{"status":76,"reviewer":77,"date":77},"unverified",null,[79],{"regimen":36,"formulation":22,"input":80,"expect":83},{"ageYears":81,"weightKg":82},40,70,{"perDose":84,"mlPerDose":85},700,0.7,[87],"V03AB34",{"status":89,"forms":90,"refs":99},"registered",[91,95],{"code":92,"en":93,"fa":94},"11908","FOMEPIZOLE 1.5G\u002F1.5ML VIAL","ویال فومپیزول ۱٫۵ گرم \u002F ۱٫۵ میلی‌لیتر",{"code":96,"en":97,"fa":98},"53092","FOMEPIZOLE (AS SULFATE) INJECTION PARENTERAL 5 mg\u002F1mL 20 mL","فرآورده تزریقی فومپیزول (معادل سولفات) ۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۲۰ میلی‌لیتر",[100],{"source":101,"section":102,"url":103},"darooyab-generic","G-1957\u002FFomepizole","https:\u002F\u002Fwww.darooyab.ir\u002FG-1957\u002FFomepizole",[105,109,113,116],{"kind":106,"url":107,"label":108},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078537","ANDA078537",{"kind":110,"url":111,"label":112},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=256910fe-91f2-48f6-b0b4-55edc52dacd4","FDA Fomepizole",{"kind":114,"url":115,"label":87},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB34",{"kind":117,"url":103,"label":8},"darooyab",{"pregnancy":119,"lactation":128,"pediatric":136,"geriatric":145},{"level":120,"text":121,"quote":124,"refs":125},"caution",{"fa":122,"en":123},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category C: Animal reproduction studies have not been conducted with fomepizole.",[126],{"source":32,"section":127},"Pregnancy:",{"level":120,"text":129,"quote":132,"refs":133},{"fa":130,"en":131},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when fomepizole is administered to a nursing woman.",[134],{"source":32,"section":135},"Nursing Mothers:",{"level":137,"text":138,"quote":141,"refs":142},"not-established",{"fa":139,"en":140},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[143],{"source":32,"section":144},"Pediatric Use:",{"level":120,"text":146,"quote":149,"refs":150},{"fa":147,"en":148},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Safety and effectiveness in geriatric patients have not been established.",[151],{"source":32,"section":152},"Geriatric Use:",{"kind":154,"refs":155,"id":108},"ANDA",[156],{"source":32,"section":157},"SPL approval \u002F marketing category",1792108424076]