[{"data":1,"prerenderedAt":160},["ShallowReactive",2],{"drug-flucytosine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":68,"warnings":78,"renal":85,"monitoring":86,"interactions":87,"review":88,"examples":91,"atc":100,"iran":102,"usApproval":114,"links":120,"populations":133},"flucytosine",1,{"fa":7,"en":8},"فلوسیتوزین","Flucytosine","anti-infectives",{"fa":11,"en":12},"ضدقارچ (آنتی‌متابولیت)","Antifungal (antimetabolite)",[14],{"name":15,"market":16},"Ancobon","US",[18,7,19],"ancobon","5-FC",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-250","capsule","oral","250 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},250,"mg",false,[16],[32],{"source":33,"section":34},"fda-flucytosine","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"cap-500","500 mg capsule",{"amount":39,"unit":28,"perUnit":23,"scored":29},500,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":51,"unit":28,"dose":52,"refs":56,"notes":59},"std","invasive-fungal",{"fa":48,"en":49},"عفونت جدی کاندیدا یا کریپتوکوک (همراه آمفوتریسین) — ۵۰ تا ۱۵۰ mg\u002Fkg\u002Fروز هر ۶ ساعت","Serious Candida or Cryptococcus infection (with amphotericin B) — 50–150 mg\u002Fkg\u002Fday every 6 h",{},"weightBased",{"perKgPerDay":53,"perKgPerDayMax":54,"dividedDoses":55},50,150,4,[57],{"source":33,"section":58},"Dosage and Administration",[60],{"text":61,"refs":64},{"fa":62,"en":63},"کپسول‌ها چندتا چندتا طی ۱۵ دقیقه (کاهش تهوع). نارسایی کلیه: دوز پایین‌تر و پایش سطح خونی. به‌تنهایی مقاومت ایجاد می‌شود.","Give capsules a few at a time over 15 min (less nausea). Renal impairment: lower dose and monitor levels. Resistance develops when used alone.",[65,66],{"source":33,"section":58},{"source":33,"section":67},"Warnings",[69],{"id":70,"severity":71,"text":72,"refs":75},"hyper","block",{"fa":73,"en":74},"حساسیت به فلوسیتوزین.","Hypersensitivity to flucytosine.",[76],{"source":33,"section":77},"Contraindications",[79],{"text":80,"refs":83},{"fa":81,"en":82},"هشدار جعبه‌ای: در نارسایی کلیه با احتیاط شدید؛ سرکوب مغز استخوان؛ پایش خون، کلیه و کبد.","Boxed warning: extreme caution in renal impairment; bone-marrow suppression; monitor haematology, renal and hepatic function.",[84],{"source":33,"section":67},[],[],[],{"status":89,"reviewer":90,"date":90},"unverified",null,[92],{"regimen":45,"formulation":22,"input":93,"expect":96},{"ageYears":94,"weightKg":95},40,60,{"perDose":97,"tabletsPerDoseRounded":98,"upperPerDose":99},750,3,2250,[101],"J02AX01",{"status":103,"forms":104,"refs":109},"registered",[105],{"code":106,"en":107,"fa":108},"00541","FLUCYTOSINE 500MG TAB","قرص فلوسیتوسین ۵۰۰ میلی‌گرم",[110],{"source":111,"section":112,"url":113},"darooyab-generic","G-718\u002FFlucytosine","https:\u002F\u002Fwww.darooyab.ir\u002FG-718\u002FFlucytosine",{"kind":115,"refs":116,"id":119},"ANDA",[117],{"source":33,"section":118},"SPL approval \u002F marketing category","ANDA204652",[121,124,128,131],{"kind":122,"url":123,"label":119},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204652",{"kind":125,"url":126,"label":127},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=bfc817db-ab65-5cd7-e053-2995a90a8ee8","FDA Flucytosine",{"kind":129,"url":130,"label":101},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J02AX01",{"kind":132,"url":113,"label":8},"darooyab",{"pregnancy":134,"lactation":143,"pediatric":152},{"level":135,"text":136,"quote":139,"refs":140},"caution",{"fa":137,"en":138},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Flucytosine Capsules USP should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[141],{"source":33,"section":142},"Pregnancy",{"level":144,"text":145,"quote":148,"refs":149},"avoid",{"fa":146,"en":147},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Flucytosine Capsules USP, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[150],{"source":33,"section":151},"Nursing Mothers",{"level":135,"text":153,"quote":156,"refs":157},{"fa":154,"en":155},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The efficacy and safety of Flucytosine Capsules USP have not been systematically studied in pediatric patients.",[158],{"source":33,"section":159},"Pediatric Use",1792191544762]