[{"data":1,"prerenderedAt":161},["ShallowReactive",2],{"drug-exemestane":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":59,"warnings":69,"renal":77,"monitoring":78,"interactions":79,"review":80,"examples":83,"atc":89,"iran":91,"usApproval":103,"links":109,"populations":125},"exemestane",1,{"fa":7,"en":8},"اگزمستان","Exemestane","antineoplastic-immunomodulating",{"fa":11,"en":12},"مهارکننده آروماتاز استروئیدی","Steroidal aromatase inactivator",[14],{"name":15,"market":16},"Aromasin","US",[18,19,7],"aromasin","آروماسین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",false,[16],[32],{"source":33,"section":34},"fda-aromasin","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48,"notes":51},"bc","breast-cancer",{"fa":40,"en":41},"سرطان پستان ER مثبت در یائسگی (کمکی پس از تاموکسیفن یا پیشرفته) — ۲۵ mg یک بار پس از غذا","ER-positive breast cancer after menopause (adjuvant after tamoxifen or advanced) — 25 mg once daily after a meal",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":5},[49],{"source":33,"section":50},"2.1",[52],{"text":53,"refs":56},{"fa":54,"en":55},"با القاگر قوی CYP3A4 (ریفامپین، فنی‌توئین): ۵۰ mg.","With strong CYP3A4 inducers (rifampin, phenytoin): 50 mg.",[57],{"source":33,"section":58},"2.2",[60],{"id":61,"severity":62,"text":63,"refs":66},"hyper","block",{"fa":64,"en":65},"حساسیت به اگزمستان.","Hypersensitivity to exemestane.",[67],{"source":33,"section":68},"4",[70],{"text":71,"refs":74},{"fa":72,"en":73},"کاهش تراکم استخوان؛ ویتامین D پایش؛ همراه استروژن نه؛ در پیش از یائسگی نه؛ سمیت جنینی.","Reduced bone mineral density; check vitamin D; not with oestrogens; not for premenopausal women; embryo-fetal toxicity.",[75],{"source":33,"section":76},"5",[],[],[],{"status":81,"reviewer":82,"date":82},"unverified",null,[84],{"regimen":37,"formulation":22,"input":85,"expect":88},{"ageYears":86,"weightKg":87},60,70,{"perDose":27,"tabletsPerDoseRounded":5},[90],"L02BG06",{"status":92,"forms":93,"refs":98},"registered",[94],{"code":95,"en":96,"fa":97},"02962","EXEMESTANE 25MG TAB","قرص اکسمستان ۲۵ میلی‌گرم",[99],{"source":100,"section":101,"url":102},"darooyab-generic","G-997\u002FExemestane","https:\u002F\u002Fwww.darooyab.ir\u002FG-997\u002FExemestane",{"kind":104,"refs":105,"id":108},"NDA",[106],{"source":33,"section":107},"SPL approval \u002F marketing category","NDA020753",[110,113,117,120,123],{"kind":111,"url":112,"label":108},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020753",{"kind":114,"url":115,"label":116},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=cf066b7a-032a-416c-8d40-15ba581423e3","FDA Aromasin",{"kind":118,"url":119,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607006.html",{"kind":121,"url":122,"label":90},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L02BG06",{"kind":124,"url":102,"label":8},"darooyab",{"pregnancy":126,"lactation":135,"pediatric":144,"reproductive":153},{"level":127,"text":128,"quote":131,"refs":132},"avoid",{"fa":129,"en":130},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings in animal studies and its mechanism of action , AROMASIN can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology (12.1) ] .",[133],{"source":33,"section":134},"8.1",{"level":136,"text":137,"quote":140,"refs":141},"caution",{"fa":138,"en":139},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information on the presence of exemestane in human milk, or on its effects on the breastfed infant or milk production.",[142],{"source":33,"section":143},"8.2",{"level":145,"text":146,"quote":149,"refs":150},"not-established",{"fa":147,"en":148},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[151],{"source":33,"section":152},"8.4",{"level":136,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females AROMASIN can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .",[159],{"source":33,"section":160},"8.3",1792444398061]