[{"data":1,"prerenderedAt":165},["ShallowReactive",2],{"drug-etonogestrel-implant":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":35,"contraindications":61,"warnings":71,"renal":86,"monitoring":87,"interactions":88,"review":89,"examples":92,"atc":98,"iran":100,"links":107,"populations":126,"usApproval":160},"etonogestrel-implant",1,{"fa":7,"en":8},"ایمپلنت اتونوژسترل","Etonogestrel implant","genitourinary-sex-hormones",{"fa":11,"en":12},"پروژستین (ضدبارداری طولانی‌اثر)","Progestin (long-acting contraceptive)",[14],{"name":15,"market":16},"Nexplanon","US",[18,19,20,21,22],"nexplanon","implanon","نکسپلانون","ایمپلانون","ایمپلنت ضدبارداری",[24],{"id":25,"form":25,"route":26,"label":27,"concentration":28,"markets":30,"refs":31},"implant","subdermal","One 68 mg etonogestrel rod in a preloaded applicator",{"amount":5,"unit":29,"perUnit":29},"application",[16],[32],{"source":33,"section":34},"fda-nexplanon","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":43,"unit":29,"dose":44,"refs":45,"durationDays":50,"notes":51},"contra","contraception",{"fa":40,"en":41},"پیشگیری از بارداری تا ۵ سال — یک ایمپلنت زیرپوستی در بازوی غیرغالب","Prevention of pregnancy for up to 5 years — one subdermal implant in the non-dominant arm",{},"fixed",{"perDose":5,"dosesPerDay":5},[46,48],{"source":33,"section":47},"1",{"source":33,"section":49},"2",{"min":5,"max":5},[52],{"text":53,"refs":56},{"fa":54,"en":55},"پیش از گذاشتن، بارداری رد شود؛ زمان گذاشتن به روش قبلی بستگی دارد. گذاشتن و خارج کردن فقط توسط فرد آموزش‌دیده (REMS).","Rule out pregnancy before insertion; timing depends on prior contraception. Insertion and removal only by trained providers (REMS).",[57,59],{"source":33,"section":58},"2.1",{"source":33,"section":60},"2.2",[62],{"id":63,"severity":64,"text":65,"refs":68},"ci","block",{"fa":66,"en":67},"بارداری قطعی یا مشکوک؛ سابقه فعلی یا قبلی ترومبوز؛ تومور کبد یا بیماری فعال کبد؛ خونریزی رحمی غیرطبیعی تشخیص‌داده‌نشده؛ سرطان پستان یا سرطان حساس به پروژستین (فعلی یا قبلی)؛ حساسیت به اجزا.","Known or suspected pregnancy; current or past thrombosis; liver tumours or active liver disease; undiagnosed abnormal uterine bleeding; current or past breast or other progestin-sensitive cancer; allergy to components.",[69],{"source":33,"section":70},"4",[72,79],{"text":73,"refs":76},{"fa":74,"en":75},"هشدار جعبه‌ای: عوارض گذاشتن یا خارج کردن نادرست (آسیب عصب و عروق، جابجایی، مهاجرت به عروق ریه).","Boxed warning: complications of improper insertion and removal (nerve\u002Fvascular injury, migration, including to pulmonary vessels).",[77],{"source":33,"section":78},"Boxed Warning",{"text":80,"refs":83},{"fa":81,"en":82},"تغییر الگوی خونریزی؛ حاملگی خارج رحمی؛ ترومبوز؛ کیست تخمدان؛ افزایش فشار خون؛ کاهش اثر با القاکننده‌های CYP3A4.","Changed bleeding pattern; ectopic pregnancy; thrombosis; ovarian cysts; raised blood pressure; reduced efficacy with CYP3A4 inducers.",[84],{"source":33,"section":85},"5",[],[],[],{"status":90,"reviewer":91,"date":91},"unverified",null,[93],{"regimen":37,"formulation":25,"input":94,"expect":97},{"ageYears":95,"weightKg":96},25,60,{"perDose":5},[99],"G03AC08",{"status":101,"refs":102},"not-found",[103],{"source":104,"section":105,"url":106},"darooyab-generic","G-3260\u002FEtonogestrel","https:\u002F\u002Fwww.darooyab.ir\u002FG-3260\u002FEtonogestrel",[108,112,116,120,123],{"kind":109,"url":110,"label":111},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021529","NDA021529",{"kind":113,"url":114,"label":115},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=487f8a62-e142-457c-97cc-2e398fde7594","FDA Nexplanon",{"kind":117,"url":118,"label":119},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625057.html","Etonogestrel Implant",{"kind":121,"url":122,"label":99},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03AC08",{"kind":124,"url":106,"label":125},"darooyab","Etonogestrel",{"pregnancy":127,"lactation":135,"pediatric":144,"geriatric":152},{"level":128,"text":129,"quote":132,"refs":133},"contraindicated",{"fa":130,"en":131},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","NEXPLANON should not be used in women who have Known or suspected pregnancy Current or past history of thrombosis or thromboembolic disorders Liver tumors, benign or malignant, or active liver disease Undiagnosed abnormal uterine bleeding Known or suspected breast cancer, personal history of breast cancer, or other …",[134],{"source":33,"section":70},{"level":136,"text":137,"quote":140,"refs":141},"caution",{"fa":138,"en":139},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Small amounts of contraceptive steroids and\u002For metabolites, including etonogestrel are present in human milk.",[142],{"source":33,"section":143},"8.2",{"level":136,"text":145,"quote":148,"refs":149},{"fa":146,"en":147},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of NEXPLANON have been established in women of reproductive potential.",[150],{"source":33,"section":151},"8.4",{"level":136,"text":153,"quote":156,"refs":157},{"fa":154,"en":155},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","This product has not been studied in women over 65 years of age and is not indicated in this population.",[158],{"source":33,"section":159},"8.5",{"kind":161,"refs":162,"id":111},"NDA",[163],{"source":33,"section":164},"SPL approval \u002F marketing category",1792444397812]