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add a progestin if the uterus is intact.",[76],{"source":37,"section":69},[78],{"id":79,"severity":80,"text":81,"refs":84},"ci","block",{"fa":82,"en":83},"خونریزی تناسلی تشخیص‌داده‌نشده؛ سرطان پستان یا وابسته به استروژن؛ DVT\u002FPE یا ترومبوز شریانی؛ بیماری کبد؛ بارداری.","Undiagnosed genital bleeding; breast or oestrogen-dependent cancer; DVT\u002FPE or arterial thrombosis; liver disease; pregnancy.",[85],{"source":86,"section":87},"fda-premarin","4",[89],{"text":90,"refs":93},{"fa":91,"en":92},"هشدار جعبه‌ای: سرطان آندومتر (بدون پروژستین در رحم سالم)، حوادث قلبی‌عروقی، سرطان پستان و دمانس احتمالی؛ کمترین دوز و کوتاه‌ترین مدت.","Boxed warning: endometrial cancer (unopposed oestrogen with a uterus), cardiovascular disorders, breast cancer and probable dementia; lowest dose, shortest time.",[94],{"source":86,"section":95},"Boxed Warning",[],[],[],{"status":100,"reviewer":101,"date":101},"unverified",null,[103],{"regimen":56,"formulation":40,"input":104,"expect":107},{"ageYears":105,"weightKg":106},52,65,{"perDose":5,"tabletsPerDoseRounded":5},[109],"G03CA03",{"status":111,"refs":112},"not-found",[113],{"source":114,"section":115,"url":116},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=estradiol",[118,122,126,129,133,136],{"kind":119,"url":120,"label":121},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040275","ANDA040275",{"kind":123,"url":124,"label":125},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9333d92f-2585-4b99-aaea-87c01c95125e","FDA Estradiol tablets",{"kind":123,"url":127,"label":128},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=258e1602-a3cf-4ccc-ca80-73dbbfb812ff","FDA Premarin",{"kind":130,"url":131,"label":132},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605041.html","Estradiol Topical",{"kind":130,"url":134,"label":135},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605042.html","Estradiol Transdermal Patch",{"kind":137,"url":138,"label":109},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03CA03",{"pregnancy":140,"lactation":149,"pediatric":158,"geriatric":167},{"level":141,"text":142,"quote":145,"refs":146},"contraindicated",{"fa":143,"en":144},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Known or suspected pregnancy.",[147],{"source":37,"section":148},"CONTRAINDICATIONS",{"level":150,"text":151,"quote":154,"refs":155},"caution",{"fa":152,"en":153},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when estradiol is administered to a nursing woman.",[156],{"source":37,"section":157},"Precautions\u002FWarnings – Nursing Mothers",{"level":159,"text":160,"quote":163,"refs":164},"not-established",{"fa":161,"en":162},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[165],{"source":37,"section":166},"Precautions\u002FWarnings – Pediatric Use",{"level":168,"text":169,"quote":172,"refs":173},"avoid",{"fa":170,"en":171},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","The Women’s Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo.",[174],{"source":37,"section":95},{"kind":176,"refs":177,"id":121},"ANDA",[178],{"source":37,"section":179},"SPL approval \u002F marketing category",1792092032368]