[{"data":1,"prerenderedAt":202},["ShallowReactive",2],{"drug-eplerenone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":87,"warnings":103,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110,"atc":120,"iran":122,"links":138,"populations":155,"usApproval":197},"eplerenone",1,{"fa":7,"en":8},"اپلرنون","Eplerenone","cardiovascular",{"fa":11,"en":12},"آنتاگونیست گیرنده مینرالوکورتیکوئید","Mineralocorticoid receptor antagonist",[14],{"name":15,"market":16},"Inspra","US",[18,19,7],"inspra","اینسپرا",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",false,[16],[32],{"source":33,"section":34},"fda-eplerenone","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-50","50 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},50,[16],[42],{"source":33,"section":34},[44,70],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":58,"notes":61},"hf","heart-failure",{"fa":48,"en":49},"نارسایی قلب پس از MI — شروع ۲۵ mg یک بار در روز، تا ۵۰ mg ظرف ۴ هفته","HF after MI — start 25 mg once daily, up to 50 mg within 4 weeks",{"minAge":51},{"value":52,"unit":53},18,"year","titration",{"dividedDoses":5,"titration":56},{"start":27,"increment":27,"incrementEveryDays":57,"targetMin":39,"targetMax":39,"max":39},28,[59],{"source":33,"section":60},"2.1",[62],{"text":63,"refs":66},{"fa":64,"en":65},"دوز بر اساس پتاسیم سرم طبق جدول ۱ برچسب تنظیم شود. پتاسیم پیش از شروع و به‌طور دوره‌ای.","Adjust by serum potassium per label Table 1. Check potassium before starting and periodically.",[67,68],{"source":33,"section":60},{"source":33,"section":69},"2.3",{"id":71,"disease":72,"label":73,"population":76,"type":78,"unit":28,"dose":79,"refs":80,"limits":83},"htn","hypertension",{"fa":74,"en":75},"فشار خون — ۵۰ mg یک بار در روز (تا ۵۰ mg دو بار)","Hypertension — 50 mg once daily (up to 50 mg twice daily)",{"minAge":77},{"value":52,"unit":53},"fixed",{"perDose":39,"dosesPerDay":5},[81],{"source":33,"section":82},"2.2",{"maxPerDay":84,"refs":85},100,[86],{"source":33,"section":82},[88,97],{"id":89,"severity":90,"text":91,"refs":94},"all","block",{"fa":92,"en":93},"همه بیماران: پتاسیم بالای ۵٫۵ هنگام شروع؛ CrCl ≤ ۳۰؛ مهارکننده قوی CYP3A.","All patients: K >5.5 at start; CrCl ≤30; strong CYP3A inhibitors.",[95],{"source":33,"section":96},"4",{"id":71,"severity":90,"text":98,"refs":101},{"fa":99,"en":100},"فشار خون: دیابت نوع ۲ با میکروآلبومینوری؛ کراتینین بالای ۲ (مرد) یا ۱٫۸ (زن)؛ CrCl زیر ۵۰؛ مکمل پتاسیم یا دیورتیک نگهدارنده پتاسیم.","Hypertension: type 2 diabetes with microalbuminuria; creatinine >2.0 (men) or >1.8 (women); CrCl \u003C50; potassium supplements or potassium-sparing diuretics.",[102],{"source":33,"section":96},[],[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111,116],{"regimen":45,"formulation":22,"input":112,"expect":115},{"ageYears":113,"weightKg":114},65,80,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":71,"formulation":36,"input":117,"expect":119},{"ageYears":118,"weightKg":114},55,{"perDose":39,"tabletsPerDoseRounded":5},[121],"C03DA04",{"status":123,"forms":124,"refs":133},"registered",[125,129],{"code":126,"en":127,"fa":128},"09626","EPLERENONE 25MG TAB","قرص اپلرنون ۲۵ میلی‌گرم",{"code":130,"en":131,"fa":132},"09644","EPLERENONE 50MG TAB","قرص اپلرنون ۵۰ میلی‌گرم",[134],{"source":135,"section":136,"url":137},"darooyab-generic","G-1664\u002FEplerenone","https:\u002F\u002Fwww.darooyab.ir\u002FG-1664\u002FEplerenone",[139,143,147,150,153],{"kind":140,"url":141,"label":142},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=208283","ANDA208283",{"kind":144,"url":145,"label":146},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e2a51c12-bdc2-4b3b-8e9e-bf363c2817ed","FDA Eplerenone",{"kind":148,"url":149,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa603004.html",{"kind":151,"url":152,"label":121},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C03DA04",{"kind":154,"url":137,"label":8},"darooyab",{"pregnancy":156,"lactation":165,"pediatric":173,"geriatric":181,"reproductive":189},{"level":157,"text":158,"quote":161,"refs":162},"caution",{"fa":159,"en":160},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The available data from published case reports on eplerenone use during pregnancy are insufficient to establish a drug-associated risk of major birth defects, miscarriage, adverse maternal or fetal outcomes (see Clinical Considerations ) .",[163],{"source":33,"section":164},"8.1",{"level":157,"text":166,"quote":169,"refs":170},{"fa":167,"en":168},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no human data available on whether eplerenone is present in human milk, or has effects on breastfed infants or on milk production.",[171],{"source":33,"section":172},"8.2",{"level":157,"text":174,"quote":177,"refs":178},{"fa":175,"en":176},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of eplerenone for treatment of hypertension have not been established in pediatric patients.",[179],{"source":33,"section":180},"8.4",{"level":157,"text":182,"quote":185,"refs":186},{"fa":183,"en":184},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","However, due to age-related decreases in creatinine clearance, the incidence of laboratory-documented hyperkalemia was increased in patients 65 and older [see Warnings and Precautions (5.1) ] .",[187],{"source":33,"section":188},"8.5",{"level":157,"text":190,"quote":193,"refs":194},{"fa":191,"en":192},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Based on animal data, use of eplerenone may compromise male fertility.",[195],{"source":33,"section":196},"8.3",{"kind":198,"refs":199,"id":142},"ANDA",[200],{"source":33,"section":201},"SPL approval \u002F marketing category",1792111453180]