[{"data":1,"prerenderedAt":157},["ShallowReactive",2],{"drug-entacapone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":63,"warnings":73,"renal":74,"monitoring":75,"interactions":76,"review":85,"examples":88,"atc":94,"iran":96,"usApproval":108,"links":114,"populations":130},"entacapone",1,{"fa":7,"en":8},"انتاکاپون","Entacapone","nervous-system",{"fa":11,"en":12},"مهارکننده COMT","COMT inhibitor",[14],{"name":15,"market":16},"Comtan","US",[18,19,7],"comtan","کامتان",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-200","tablet","oral","200 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},200,"mg",false,[16],[32],{"source":33,"section":34},"fda-entacapone","How Supplied",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":49,"limits":52,"notes":56},"pd","parkinsons",{"fa":40,"en":41},"پارکینسون با پدیده wearing-off — ۲۰۰ mg همراه هر دوز لوودوپا\u002Fکاربیدوپا (حداکثر ۸ بار در روز)","Parkinson’s with wearing-off — 200 mg with each levodopa\u002Fcarbidopa dose (max 8 times daily)",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":48},4,[50],{"source":33,"section":51},"Dosage and Administration",{"maxPerDay":53,"refs":54},1600,[55],{"source":33,"section":51},[57],{"text":58,"refs":61},{"fa":59,"en":60},"همیشه همراه لوودوپا\u002Fکاربیدوپا؛ به‌تنهایی اثر ضدپارکینسون ندارد. ماشین‌حساب ۴ دوز را نشان می‌دهد؛ تعداد دوز = تعداد دوز لوودوپا. ممکن است کاهش دوز لوودوپا لازم شود.","Always with levodopa\u002Fcarbidopa; no antiparkinsonian effect alone. The calculator shows 4 doses; number of doses = number of levodopa doses. Levodopa dose may need reduction.",[62],{"source":33,"section":51},[64],{"id":65,"severity":66,"text":67,"refs":70},"hyper","block",{"fa":68,"en":69},"حساسیت به انتاکاپون.","Hypersensitivity to entacapone.",[71],{"source":33,"section":72},"Contraindications",[],[],[],[77],{"with":78,"text":79,"refs":82},"maoi",{"fa":80,"en":81},"MAOI غیرانتخابی (فنلزین، ترانیل‌سیپرومین): همزمان نه.","Non-selective MAOIs (phenelzine, tranylcypromine): should not be combined.",[83],{"source":33,"section":84},"Warnings",{"status":86,"reviewer":87,"date":87},"unverified",null,[89],{"regimen":37,"formulation":22,"input":90,"expect":93},{"ageYears":91,"weightKg":92},65,70,{"perDose":27,"tabletsPerDoseRounded":5},[95],"N04BX02",{"status":97,"forms":98,"refs":103},"registered",[99],{"code":100,"en":101,"fa":102},"06428","ENTACAPONE 200MG TAB","قرص انتاکاپون ۲۰۰ میلی‌گرم",[104],{"source":105,"section":106,"url":107},"darooyab-generic","G-2489\u002FEntacapone","https:\u002F\u002Fwww.darooyab.ir\u002FG-2489\u002FEntacapone",{"kind":109,"refs":110,"id":113},"ANDA",[111],{"source":33,"section":112},"SPL approval \u002F marketing category","ANDA207210",[115,118,122,125,128],{"kind":116,"url":117,"label":113},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207210",{"kind":119,"url":120,"label":121},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=56327e32-3b06-4144-91a0-bb1908842e33","FDA Entacapone",{"kind":123,"url":124,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601236.html",{"kind":126,"url":127,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N04BX02",{"kind":129,"url":107,"label":8},"darooyab",{"pregnancy":131,"lactation":140,"pediatric":148},{"level":132,"text":133,"quote":136,"refs":137},"caution",{"fa":134,"en":135},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category C.",[138],{"source":33,"section":139},"Pregnancy",{"level":132,"text":141,"quote":144,"refs":145},{"fa":142,"en":143},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when entacapone is administered to a nursing woman.",[146],{"source":33,"section":147},"Nursing Mothers",{"level":149,"text":150,"quote":153,"refs":154},"not-established",{"fa":151,"en":152},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[155],{"source":33,"section":156},"Pediatric Use",1792156176797]