[{"data":1,"prerenderedAt":209},["ShallowReactive",2],{"drug-enalapril":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":61,"contraindications":141,"warnings":169,"renal":170,"monitoring":178,"interactions":179,"review":180,"examples":183},"enalapril",1,{"fa":7,"en":8},"انالاپریل","Enalapril","cardiovascular",{"fa":11,"en":12},"مهارکننده ACE","ACE inhibitor",[14],{"name":15,"market":16},"Vasotec","US",[18,7,19,20],"vasotec","enalapril maleate","ACEI",[22,36,44,53],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-2-5","tablet","oral","2.5 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},2.5,"mg",true,[16],[33],{"source":34,"section":35},"fda-enalapril","How Supplied",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-5","5 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},5,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":50,"refs":51},"tab-10","10 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":49},10,false,[16],[52],{"source":34,"section":35},{"id":54,"form":24,"route":25,"label":55,"concentration":56,"markets":58,"refs":59},"tab-20","20 mg tablet",{"amount":57,"unit":29,"perUnit":24,"scored":49},20,[16],[60],{"source":34,"section":35},[62,90,118],{"id":63,"disease":64,"label":65,"population":68,"type":72,"unit":29,"dose":73,"refs":74,"limits":77,"notes":82},"adult-htn","hypertension",{"fa":66,"en":67},"فشار خون — بزرگسال: شروع ۵ mg یک بار در روز","Hypertension — adults: start 5 mg once daily",{"minAge":69},{"value":70,"unit":71},18,"year","fixed",{"perDose":40,"dosesPerDay":5},[75],{"source":34,"section":76},"Dosage and Administration, Hypertension",{"maxPerDay":78,"refs":79},40,[80],{"source":34,"section":81},"Dosage and Administration, Renal Impairment",[83],{"text":84,"refs":87},{"fa":85,"en":86},"محدوده معمول ۱۰ تا ۴۰ mg\u002Fday در یک یا دو نوبت. اگر دیورتیک قطع نمی‌شود: شروع ۲٫۵ mg زیر نظر. CrCl ≤۳۰: شروع ۲٫۵ mg.","Usual range 10–40 mg\u002Fday in one or two doses. If a diuretic cannot be stopped: start 2.5 mg under supervision. CrCl ≤30: start 2.5 mg.",[88,89],{"source":34,"section":76},{"source":34,"section":81},{"id":91,"disease":64,"label":92,"population":95,"type":100,"unit":29,"dose":101,"refs":103,"limits":108,"notes":111},"peds-htn",{"fa":93,"en":94},"فشار خون — ۱ ماه تا ۱۶ سال: ۰٫۰۸ mg\u002Fkg یک بار در روز (حداکثر ۵ mg شروع)","Hypertension — 1 month–16 y: 0.08 mg\u002Fkg once daily (start up to 5 mg)",{"minAge":96,"maxAge":98},{"value":5,"unit":97},"month",{"value":99,"unit":71},17,"weightBased",{"perKgPerDay":102,"dividedDoses":5},0.08,[104,106],{"source":34,"section":105},"Dosage and Administration, Pediatric Hypertensive Patients",{"source":34,"section":107},"Pediatric Use",{"maxPerDose":40,"refs":109},[110],{"source":34,"section":105},[112],{"text":113,"refs":116},{"fa":114,"en":115},"دوز بر اساس پاسخ فشار تنظیم شود. دوز بالاتر از ۰٫۵۸ mg\u002Fkg (یا بیش از ۴۰ mg) در کودکان مطالعه نشده.","Adjust to blood-pressure response. Doses above 0.58 mg\u002Fkg (or over 40 mg) not studied in children.",[117],{"source":34,"section":105},{"id":119,"disease":120,"label":121,"population":124,"type":72,"unit":29,"dose":126,"refs":127,"limits":130,"notes":134},"hf","heart-failure",{"fa":122,"en":123},"نارسایی قلبی — بزرگسال: شروع ۲٫۵ mg","Heart failure — adults: start 2.5 mg",{"minAge":125},{"value":70,"unit":71},{"perDose":28,"dosesPerDay":5},[128],{"source":34,"section":129},"Dosage and Administration, Heart Failure",{"maxPerDay":78,"refs":131},[132],{"source":34,"section":133},"Dosage and Administration, Heart Failure and Renal Impairment",[135],{"text":136,"refs":139},{"fa":137,"en":138},"افزایش به ۲٫۵ mg دو بار، سپس ۵ mg دو بار و بیشتر، معمولاً با فاصله ≥۴ روز؛ حداکثر ۴۰ mg\u002Fday.","Increase to 2.5 mg twice daily, then 5 mg twice daily and higher, usually ≥4 days apart; max 40 mg\u002Fday.",[140],{"source":34,"section":133},[142,151,160],{"id":143,"severity":144,"text":145,"refs":148},"angioedema","block",{"fa":146,"en":147},"سابقه آنژیوادم (با ACEI، ارثی یا ایدیوپاتیک)؛ همراه ساکوبیتریل (۳۶ ساعت فاصله)؛ آلیسکیرن در دیابت؛ حساسیت.","History of angioedema (ACE inhibitor, hereditary or idiopathic); with sacubitril (36 h gap); aliskiren in diabetes; hypersensitivity.",[149],{"source":34,"section":150},"Contraindications",{"id":152,"severity":144,"rule":153,"text":155,"refs":158},"neonate",{"maxAge":154},{"value":5,"unit":97},{"fa":156,"en":157},"در نوزادان توصیه نمی‌شود (داده‌ای نیست).","Not recommended in neonates (no data).",[159],{"source":34,"section":105},{"id":161,"severity":162,"text":163,"refs":166},"pregnancy","warn",{"fa":164,"en":165},"هشدار جعبه‌ای: سمیت جنینی — با تشخیص بارداری فوراً قطع شود.","Boxed warning: fetal toxicity — stop as soon as pregnancy is detected.",[167],{"source":34,"section":168},"Boxed Warning",[],[171],{"egfrBelow":172,"severity":144,"text":173,"refs":176},30,{"fa":174,"en":175},"در کودکان با GFR کمتر از ۳۰ توصیه نمی‌شود.","Not recommended in children with GFR \u003C30 mL\u002Fmin\u002F1.73 m².",[177],{"source":34,"section":105},[],[],{"status":181,"reviewer":182,"date":182},"unverified",null,[184,189,194,198,204],{"regimen":63,"formulation":37,"input":185,"expect":188},{"ageYears":186,"weightKg":187},45,80,{"perDose":40,"tabletsPerDoseRounded":5},{"regimen":91,"formulation":23,"input":190,"expect":192},{"ageYears":191,"weightKg":172},9,{"perDose":193,"tabletsPerDoseRounded":5},2.4,{"regimen":91,"formulation":37,"input":195,"expect":197},{"ageYears":196,"weightKg":187},15,{"perDose":40},{"regimen":91,"formulation":23,"input":199,"expect":202},{"ageYears":200,"weightKg":201},0.05,4,{"status":203},"blocked",{"regimen":119,"formulation":23,"input":205,"expect":208},{"ageYears":206,"weightKg":207},60,75,{"perDose":28},1792078534813]