[{"data":1,"prerenderedAt":153},["ShallowReactive",2],{"drug-eluxadoline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":68,"warnings":78,"renal":86,"monitoring":95,"interactions":96,"review":97,"examples":100,"atc":106,"iran":108,"usApproval":115,"links":121,"populations":135},"eluxadoline",1,{"fa":7,"en":8},"الوکسادولین","Eluxadoline","alimentary-metabolism",{"fa":11,"en":12},"آگونیست گیرنده اپیوئیدی μ\u002Fκ روده (ضداسهال)","Gut mu\u002Fkappa opioid agonist (antidiarrhoeal)",[14],{"name":15,"market":16},"Viberzi","US",[18,19,7],"viberzi","وایبرزی",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-100","tablet","oral","100 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},100,"mg",false,[16],[32],{"source":33,"section":34},"fda-viberzi","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-75","75 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},75,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":57,"allowedFormulations":60,"notes":61},"ibsd","ibs",{"fa":48,"en":49},"IBS با اسهال بزرگسال — ۱۰۰ mg دو بار با غذا","IBS with diarrhoea, adults — 100 mg twice daily with food",{"minAge":51},{"value":52,"unit":53},18,"year","fixed",{"perDose":27,"dosesPerDay":56},2,[58],{"source":33,"section":59},"2",[22],[62],{"text":63,"refs":66},{"fa":64,"en":65},"۷۵ mg دو بار: عدم تحمل ۱۰۰ mg، مهارکننده OATP1B1، نارسایی خفیف\u002Fمتوسط کبد، eGFR زیر ۶۰ یا ESRD بدون دیالیز. در یبوست شدید قطع.","75 mg twice daily: intolerance of 100 mg, OATP1B1 inhibitors, mild\u002Fmoderate hepatic impairment, eGFR \u003C60, or ESRD not on dialysis. Stop if severe constipation.",[67],{"source":33,"section":59},[69],{"id":70,"severity":71,"text":72,"refs":75},"ci","block",{"fa":73,"en":74},"نداشتن کیسه صفرا؛ انسداد مجرای صفراوی یا اختلال اسفنکتر اودی؛ الکلیسم یا بیش از ۳ نوشیدنی الکلی در روز؛ سابقه پانکراتیت یا بیماری ساختاری پانکراس؛ نارسایی شدید کبد؛ سابقه یبوست شدید یا انسداد مکانیکی روده؛ حساسیت.","No gallbladder; biliary duct obstruction or sphincter of Oddi disease; alcoholism or >3 alcoholic drinks a day; history of pancreatitis or structural pancreatic disease; severe hepatic impairment; history of severe constipation or mechanical bowel obstruction; hypersensitivity.",[76],{"source":33,"section":77},"4",[79],{"text":80,"refs":83},{"fa":81,"en":82},"پانکراتیت؛ اسپاسم اسفنکتر اودی؛ واکنش حساسیتی؛ یبوست.","Pancreatitis; sphincter of Oddi spasm; hypersensitivity; constipation.",[84],{"source":33,"section":85},"5",[87],{"egfrBelow":88,"severity":89,"text":90,"refs":93},60,"warn",{"fa":91,"en":92},"eGFR زیر ۶۰ (و ESRD بدون دیالیز): ۷۵ mg دو بار.","eGFR \u003C60 (and ESRD not on dialysis): 75 mg twice daily.",[94],{"source":33,"section":59},[],[],{"status":98,"reviewer":99,"date":99},"unverified",null,[101],{"regimen":45,"formulation":22,"input":102,"expect":105},{"ageYears":103,"weightKg":104},40,70,{"perDose":27,"tabletsPerDoseRounded":5},[107],"A07DA06",{"status":109,"refs":110},"not-found",[111],{"source":112,"section":113,"url":114},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Eluxadoline",{"kind":116,"refs":117,"id":120},"NDA",[118],{"source":33,"section":119},"SPL approval \u002F marketing category","NDA206940",[122,125,129,132],{"kind":123,"url":124,"label":120},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=206940",{"kind":126,"url":127,"label":128},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=7821bd40-4c84-4984-951b-6436ae20421a","FDA Viberzi",{"kind":130,"url":131,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa615054.html",{"kind":133,"url":134,"label":107},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A07DA06",{"pregnancy":136,"lactation":145},{"level":137,"text":138,"quote":141,"refs":142},"caution",{"fa":139,"en":140},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no studies with VIBERZI in pregnant women that inform any drug-associated risks.",[143],{"source":33,"section":144},"8.1",{"level":137,"text":146,"quote":149,"refs":150},{"fa":147,"en":148},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary No data are available regarding the presence of eluxadoline in human milk, the effects of eluxadoline on the breastfed infant, or the effects of eluxadoline on milk production.",[151],{"source":33,"section":152},"8.2",1792191540961]