[{"data":1,"prerenderedAt":157},["ShallowReactive",2],{"drug-edetate-calcium-disodium":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":59,"warnings":69,"renal":76,"monitoring":77,"interactions":78,"review":79,"examples":82,"atc":90,"iran":92,"links":112,"populations":127,"usApproval":152},"edetate-calcium-disodium",1,{"fa":7,"en":8},"ادتات کلسیم دی‌سدیم (CaNa2EDTA)","Edetate calcium disodium (CaNa2EDTA)","various",{"fa":11,"en":12},"شلات‌کننده سرب","Lead chelator",[14],{"name":15,"market":16},"Calcium Disodium Versenate","US",[18,19,20,21],"edta","versenate","ورسنات","ادتات کلسیم",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"vial-200","injection","iv","200 mg\u002FmL, 5 mL vial (1 g)",{"amount":29,"unit":30,"perVolumeMl":5},200,"mg",[16],[33],{"source":34,"section":35},"fda-edetate-calcium","How Supplied",[37],{"id":38,"disease":39,"label":40,"population":43,"type":44,"unit":30,"dose":45,"refs":47,"notes":50},"lead","heavy-metal-poisoning",{"fa":41,"en":42},"مسمومیت سرب بدون علامت (سرب خون ۲۰ تا ۷۰ mcg\u002FdL) — ۱۰۰۰ mg\u002Fm²\u002Fروز وریدی یا عضلانی","Asymptomatic lead poisoning (blood lead 20–70 mcg\u002FdL) — 1000 mg\u002Fm²\u002Fday IV or IM",{},"bsa",{"perM2PerDay":46,"dividedDoses":5},1000,[48],{"source":34,"section":49},"Dosage and Administration",[51],{"text":52,"refs":55},{"fa":53,"en":54},"ابتدا منبع سرب حذف شود. انسفالوپاتی سربی و ادم مغزی: عضلانی ترجیح دارد (افزایش کشنده فشار داخل جمجمه با انفوزیون وریدی).","Remove the lead source first. Lead encephalopathy with cerebral oedema: IM preferred (fatal ICP rise with IV infusion).",[56,57],{"source":34,"section":49},{"source":34,"section":58},"Boxed Warning",[60],{"id":61,"severity":62,"text":63,"refs":66},"ci","block",{"fa":64,"en":65},"آنوری؛ بیماری فعال کلیه یا هپاتیت.","Anuria; active renal disease or hepatitis.",[67],{"source":34,"section":68},"Contraindications",[70],{"text":71,"refs":74},{"fa":72,"en":73},"هشدار جعبه‌ای: سمیت کشنده؛ در انسفالوپاتی سربی افزایش کشنده فشار داخل جمجمه با انفوزیون وریدی سریع. با ادتات دی‌سدیم (بدون کلسیم) اشتباه نشود.","Boxed warning: potentially fatal toxicity; fatal ICP rise with rapid IV infusion in lead encephalopathy. Do not confuse with edetate disodium (calcium-free).",[75],{"source":34,"section":58},[],[],[],{"status":80,"reviewer":81,"date":81},"unverified",null,[83],{"regimen":38,"formulation":24,"input":84,"expect":88},{"ageYears":85,"weightKg":86,"heightCm":87},6,25,144,{"perDose":46,"mlPerDose":89},5,[91],"V03AB03",{"status":93,"forms":94,"refs":107},"registered",[95,99,103],{"code":96,"en":97,"fa":98},"00480","EDETATE CALCIUM DISODIUM 1.9G\u002F10ML AMP","آمپول ادتات کلسیم دی‌سدیم ۱٫۹ گرم \u002F ۱۰ میلی‌لیتر",{"code":100,"en":101,"fa":102},"01485","EDETATE CALCIUM DISODIUM 50MG\u002FML AMP","آمپول ادتات کلسیم دی‌سدیم ۵۰ میلی‌گرم \u002F میلی‌لیتر",{"code":104,"en":105,"fa":106},"50075","EDETATE CALCIUM DISODIUM INJECTION PARENTERAL 200 mg\u002F1mL 5 mL","فرآورده تزریقی ادتات کلسیم دی‌سدیم ۲۰۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۵ میلی‌لیتر",[108],{"source":109,"section":110,"url":111},"darooyab-generic","G-1979\u002FCalcium-Disodium-Edetate","https:\u002F\u002Fwww.darooyab.ir\u002FG-1979\u002FCalcium-Disodium-Edetate",[113,117,121,124],{"kind":114,"url":115,"label":116},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=216435","ANDA216435",{"kind":118,"url":119,"label":120},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=710a2c8c-3620-4f6f-b8fc-fb19ab9e9f22","FDA Edetate Ca disodium",{"kind":122,"url":123,"label":91},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=V03AB03",{"kind":125,"url":111,"label":126},"darooyab","Calcium-Disodium-Edetate",{"pregnancy":128,"lactation":137,"pediatric":145},{"level":129,"text":130,"quote":133,"refs":134},"caution",{"fa":131,"en":132},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.",[135],{"source":34,"section":136},"Pregnancy",{"level":129,"text":138,"quote":141,"refs":142},{"fa":139,"en":140},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when edetate calcium disodium is administered to a nursing woman.",[143],{"source":34,"section":144},"Nursing Mothers",{"level":129,"text":146,"quote":149,"refs":150},{"fa":147,"en":148},"برچسب: انسفالوپاتی سربی در کودکان شایع‌تر و مرگ‌بار است؛ در ادم مغزی تزریق عضلانی ترجیح دارد و انفوزیون سریع وریدی ممنوع.","Label: lead encephalopathy is more common and lethal in children; with cerebral oedema the IM route is preferred and rapid IV infusion avoided.","Lead encephalopathy is relatively rare in adults, but occurs more often in pediatric patients in whom it may be incipient and thus overlooked. The mortality rate in pediatric patients has been high. Patients with lead encephalopathy and cerebral edema may experience a lethal increase in intracranial pressure following intravenous infusion; the intramuscular route is preferred for these patients.",[151],{"source":34,"section":58},{"kind":153,"refs":154,"id":116},"ANDA",[155],{"source":34,"section":156},"SPL approval \u002F marketing category",1792444395644]