[{"data":1,"prerenderedAt":152},["ShallowReactive",2],{"drug-dorzolamide-timolol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":55,"warnings":65,"renal":66,"monitoring":67,"interactions":68,"review":69,"examples":72,"atc":78,"iran":80,"usApproval":92,"links":98,"populations":116},"dorzolamide-timolol",1,{"fa":7,"en":8},"قطره چشمی دورزولامید + تیمولول","Dorzolamide + timolol eye drops","sensory-organs",{"fa":11,"en":12},"مهارکننده کربنیک انیدراز + بتابلاکر","Carbonic anhydrase inhibitor + beta-blocker",[14],{"name":15,"market":16},"Cosopt","US",[18,19,20],"cosopt","کوزوپت","دورزولامید تیمولول",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"sol","eye-drops","ophthalmic","Dorzolamide 2% + timolol 0.5% eye drops",{"amount":5,"unit":28,"perUnit":28},"drop",[16],[31],{"source":32,"section":33},"fda-cosopt","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":42,"unit":28,"dose":43,"refs":45,"notes":48},"iop","glaucoma",{"fa":39,"en":40},"گلوکوم یا فشار بالای چشم — یک قطره دو بار در روز","Glaucoma or ocular hypertension — 1 drop twice daily",{},"fixed",{"perDose":5,"dosesPerDay":44},2,[46],{"source":32,"section":47},"2",[49],{"text":50,"refs":53},{"fa":51,"en":52},"با سایر قطره‌ها دست‌کم ۵ دقیقه فاصله.","At least 5 minutes apart from other eye drops.",[54],{"source":32,"section":47},[56],{"id":57,"severity":58,"text":59,"refs":62},"ci","block",{"fa":60,"en":61},"آسم یا سابقه آسم، COPD شدید؛ برادی‌کاردی سینوسی، بلوک AV درجه ۲ یا ۳، نارسایی آشکار قلب، شوک کاردیوژنیک؛ حساسیت.","Asthma or history of asthma, severe COPD; sinus bradycardia, 2nd\u002F3rd-degree AV block, overt heart failure, cardiogenic shock; hypersensitivity.",[63],{"source":32,"section":64},"4",[],[],[],[],{"status":70,"reviewer":71,"date":71},"unverified",null,[73],{"regimen":36,"formulation":23,"input":74,"expect":77},{"ageYears":75,"weightKg":76},60,70,{"perDose":5,"dosesPerDay":44},[79],"S01ED51",{"status":81,"forms":82,"refs":87},"registered",[83],{"code":84,"en":85,"fa":86},"00469","DORZOLAMIDE HCL 2% OPH DROP","قطره چشمی دورزولامید هیدروکلراید ۲ درصد",[88],{"source":89,"section":90,"url":91},"darooyab-generic","G-1653\u002FDorzolamide","https:\u002F\u002Fwww.darooyab.ir\u002FG-1653\u002FDorzolamide",{"kind":93,"refs":94,"id":97},"ANDA",[95],{"source":32,"section":96},"SPL approval \u002F marketing category","ANDA207629",[99,102,106,110,113],{"kind":100,"url":101,"label":97},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207629",{"kind":103,"url":104,"label":105},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2d5dcaa5-97ee-40c3-aa29-fcfb91fb78e1","FDA Dorzolamide\u002Ftimolol",{"kind":107,"url":108,"label":109},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa697049.html","Dorzolamide Ophthalmic",{"kind":111,"url":112,"label":79},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=S01ED51",{"kind":114,"url":91,"label":115},"darooyab","Dorzolamide",{"pregnancy":117,"lactation":126,"pediatric":135,"geriatric":143},{"level":118,"text":119,"quote":122,"refs":123},"caution",{"fa":120,"en":121},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Dorzolamide hydrochloride and timolol maleate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[124],{"source":32,"section":125},"8.1",{"level":127,"text":128,"quote":131,"refs":132},"avoid",{"fa":129,"en":130},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions from dorzolamide hydrochloride and timolol maleate in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[133],{"source":32,"section":134},"8.3",{"level":118,"text":136,"quote":139,"refs":140},{"fa":137,"en":138},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of dorzolamide hydrochloride ophthalmic solution and timolol maleate ophthalmic solution have been established when administered individually in pediatric patients aged 2 years and older.",[141],{"source":32,"section":142},"8.4",{"level":144,"text":145,"quote":148,"refs":149},"ok",{"fa":146,"en":147},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness have been observed between elderly and younger patients.",[150],{"source":32,"section":151},"8.5",1792115177908]