[{"data":1,"prerenderedAt":176},["ShallowReactive",2],{"drug-divalproex":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":55,"contraindications":120,"warnings":141,"renal":149,"monitoring":150,"interactions":157,"review":158,"examples":161},"divalproex",1,{"fa":7,"en":8},"والپروات (دیوالپروکس)","Divalproex sodium (valproate)","psychiatry",{"fa":11,"en":12},"ضدتشنج و تثبیت‌کننده خلق","Anticonvulsant and mood stabilizer",[14],{"name":15,"market":16},"Depakote","US",[18,19,20,21,22,23],"valproate","والپروات","دپاکین","depakine","sodium valproate","والپروات سدیم",[25,39,47],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":34,"refs":35},"dr-125","tablet","oral","125 mg delayed-release tablet",{"amount":31,"unit":32,"perUnit":27,"scored":33},125,"mg",false,[16],[36],{"source":37,"section":38},"fda-divalproex","3",{"id":40,"form":27,"route":28,"label":41,"concentration":42,"markets":44,"refs":45},"dr-250","250 mg delayed-release tablet",{"amount":43,"unit":32,"perUnit":27,"scored":33},250,[16],[46],{"source":37,"section":38},{"id":48,"form":27,"route":28,"label":49,"concentration":50,"markets":52,"refs":53},"dr-500","500 mg delayed-release tablet",{"amount":51,"unit":32,"perUnit":27,"scored":33},500,[16],[54],{"source":37,"section":38},[56,83,108],{"id":57,"disease":57,"label":58,"population":61,"type":65,"unit":32,"dose":66,"refs":69,"limits":72,"notes":76},"epilepsy",{"fa":59,"en":60},"تشنج پارشیل کمپلکس — ۱۰ سال به بالا: شروع ۱۰ تا ۱۵ mg\u002Fkg\u002Fday","Complex partial seizures — ≥10 y: start 10–15 mg\u002Fkg\u002Fday",{"minAge":62},{"value":63,"unit":64},10,"year","weightBased",{"perKgPerDay":63,"perKgPerDayMax":67,"dividedDoses":68},15,2,[70],{"source":37,"section":71},"2.2",{"maxPerKgPerDay":73,"refs":74},60,[75],{"source":37,"section":71},[77],{"text":78,"refs":81},{"fa":79,"en":80},"افزایش ۵ تا ۱۰ mg\u002Fkg\u002Fهفته؛ پاسخ معمولاً زیر ۶۰ mg\u002Fkg\u002Fday؛ سطح سرمی ۵۰ تا ۱۰۰ mcg\u002FmL. دوز روزانه بالای ۲۵۰ mg در نوبت‌های منقسم.","Increase 5–10 mg\u002Fkg\u002Fweek; response usually below 60 mg\u002Fkg\u002Fday; serum 50–100 mcg\u002FmL. Daily doses above 250 mg in divided doses.",[82],{"source":37,"section":71},{"id":84,"disease":85,"label":86,"population":89,"type":92,"unit":32,"dose":93,"refs":95,"limits":98,"notes":101},"mania","bipolar-mania",{"fa":87,"en":88},"مانیا — بزرگسال: شروع ۷۵۰ mg روزانه در دوزهای منقسم","Mania — adults: start 750 mg daily divided",{"minAge":90},{"value":91,"unit":64},18,"fixed",{"perDose":94,"dosesPerDay":68},375,[96],{"source":37,"section":97},"2.1",{"maxPerKgPerDay":73,"refs":99},[100],{"source":37,"section":97},[102],{"text":103,"refs":106},{"fa":104,"en":105},"افزایش سریع تا کمترین دوز مؤثر؛ سطح سرمی ۵۰ تا ۱۲۵ mcg\u002FmL؛ حداکثر ۶۰ mg\u002Fkg\u002Fday.","Increase rapidly to lowest effective dose; trough 50–125 mcg\u002FmL; max 60 mg\u002Fkg\u002Fday.",[107],{"source":37,"section":97},{"id":109,"disease":110,"label":111,"population":114,"type":92,"unit":32,"dose":116,"refs":117},"migraine","migraine-prophylaxis",{"fa":112,"en":113},"پیشگیری از میگرن — بزرگسال: ۲۵۰ mg دو بار در روز","Migraine prophylaxis — adults: 250 mg twice daily",{"minAge":115},{"value":91,"unit":64},{"perDose":43,"perDoseMax":51,"dosesPerDay":68},[118],{"source":37,"section":119},"2.3",[121,130],{"id":122,"severity":123,"text":124,"refs":127},"hepatic","block",{"fa":125,"en":126},"بیماری یا اختلال شدید کبدی؛ اختلال میتوکندریایی POLG؛ حساسیت.","Hepatic disease or significant dysfunction; POLG mitochondrial disorders; hypersensitivity.",[128],{"source":37,"section":129},"4",{"id":131,"severity":132,"rule":133,"text":135,"refs":138},"under-2","warn",{"maxAge":134},{"value":68,"unit":64},{"fa":136,"en":137},"زیر ۲ سال خطر بسیار بالای سمیت کبدی کشنده؛ فقط با احتیاط شدید و به‌تنهایی.","Under 2 years: considerably increased risk of fatal hepatotoxicity; extreme caution, sole agent.",[139],{"source":37,"section":140},"8.4",[142],{"text":143,"refs":146},{"fa":144,"en":145},"هشدار جعبه‌ای: سمیت کبدی کشنده، تراتوژنیسیته و پانکراتیت.","Boxed warning: fatal hepatotoxicity, teratogenicity and pancreatitis.",[147],{"source":37,"section":148},"WARNING: LIFE THREATENING ADVERSE REACTIONS",[],[151],{"text":152,"refs":155},{"fa":153,"en":154},"آزمایش کبد قبل از درمان و به‌طور مکرر، به‌ویژه ۶ ماه اول.","Liver tests before and frequently during therapy, especially first 6 months.",[156],{"source":37,"section":148},[],{"status":159,"reviewer":160,"date":160},"unverified",null,[162,167,173],{"regimen":57,"formulation":26,"input":163,"expect":166},{"ageYears":164,"weightKg":165},12,50,{"perDose":43,"tabletsPerDoseRounded":68,"upperPerDose":94},{"regimen":84,"formulation":26,"input":168,"expect":171},{"ageYears":169,"weightKg":170},30,70,{"perDose":94,"tabletsPerDoseRounded":172},3,{"regimen":109,"formulation":40,"input":174,"expect":175},{"ageYears":169,"weightKg":170},{"perDose":43,"upperPerDose":51},1792078534559]