[{"data":1,"prerenderedAt":225},["ShallowReactive",2],{"drug-dexmedetomidine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":109,"warnings":110,"renal":118,"monitoring":119,"interactions":120,"review":121,"examples":124,"atc":143,"iran":145,"usApproval":165,"links":171,"populations":191},"dexmedetomidine",1,{"fa":7,"en":8},"دکسمدتومیدین","Dexmedetomidine","nervous-system",{"fa":11,"en":12},"آگونیست آلفا-۲ (آرام‌بخش)","Alpha-2 agonist (sedative)",[14],{"name":15,"market":16},"Precedex","US",[18,19,20],"precedex","پرسدکس","دکس مدتومیدین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"bag-4","injection","iv","4 mcg\u002FmL ready-to-use (200 mcg\u002F50 mL, 400 mcg\u002F100 mL)",{"amount":28,"unit":29,"perVolumeMl":5},4,"mcg",[16],[32],{"source":33,"section":34},"fda-precedex","3",[36,60,88],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":49,"durationDays":52,"notes":53},"load","icu-sedation",{"fa":40,"en":41},"دوز بارگذاری ICU یا پروسیجر — بزرگسال: ۱ mcg\u002Fkg در ۱۰ دقیقه","Loading for ICU or procedural sedation — adult: 1 mcg\u002Fkg over 10 min",{"minAge":43},{"value":44,"unit":45},18,"year","weightBased",{"perKgPerDose":5,"intervalHours":48},24,[50],{"source":33,"section":51},"2.2, Table 1",{"min":5,"max":5},[54],{"text":55,"refs":58},{"fa":56,"en":57},"بیمار در حال تعویض از آرام‌بخش دیگر ممکن است بارگذاری نخواهد. پروسیجر کم‌تهاجمی (مثلاً چشم): ۰٫۵ mcg\u002Fkg. سالمند و نارسایی کبد: کاهش دوز.","Patients switched from another sedative may not need a load. Less invasive procedures (e.g. eye): 0.5 mcg\u002Fkg. Elderly and hepatic impairment: consider reduction.",[59],{"source":33,"section":51},{"id":61,"disease":38,"label":62,"population":65,"type":67,"unit":29,"dose":68,"refs":71,"notes":73},"icu",{"fa":63,"en":64},"نگهدارنده ICU — بزرگسال: ۰٫۲ تا ۰٫۷ mcg\u002Fkg\u002Fساعت","ICU maintenance — adult: 0.2–0.7 mcg\u002Fkg\u002Fhour",{"minAge":66},{"value":44,"unit":45},"infusion",{"perKgPerMin":69,"perKgPerMinMax":70},0.00333,0.01167,[72],{"source":33,"section":51},[74,81],{"text":75,"refs":78},{"fa":76,"en":77},"دوز برچسب «mcg\u002Fkg\u002Fساعت» است؛ ماشین‌حساب همان را به دقیقه و mL\u002Fساعت تبدیل کرده است.","The label dose is in mcg\u002Fkg\u002FHOUR; the calculator converts it to per minute and mL\u002Fh.",[79],{"source":33,"section":80},"2.2",{"text":82,"refs":85},{"fa":83,"en":84},"بیش از ۲۴ ساعت انفوزیون اندیکاسیون ندارد.","Not indicated for infusions longer than 24 h.",[86],{"source":33,"section":87},"2.1",{"id":89,"disease":38,"label":90,"population":93,"type":46,"unit":29,"dose":97,"refs":98,"durationDays":101,"notes":102},"load-child",{"fa":91,"en":92},"بارگذاری پروسیجر غیرتهاجمی کودک — ۱ ماه تا \u003C۲ سال: ۱٫۵ mcg\u002Fkg؛ ۲ تا \u003C۱۸ سال: ۲ mcg\u002Fkg (در ۱۰ دقیقه)","Pediatric non-invasive procedure load — 1 month–\u003C2 y: 1.5 mcg\u002Fkg; 2–\u003C18 y: 2 mcg\u002Fkg (over 10 min)",{"minAge":94,"maxAge":96},{"value":95,"unit":45},2,{"value":44,"unit":45},{"perKgPerDose":95,"intervalHours":48},[99],{"source":33,"section":100},"2.2, Table 2",{"min":5,"max":5},[103],{"text":104,"refs":107},{"fa":105,"en":106},"نگهدارنده کودک: معمولاً شروع ۱٫۵ mcg\u002Fkg\u002Fساعت، محدوده ۰٫۵ تا ۱٫۵.","Pediatric maintenance: usually start 1.5 mcg\u002Fkg\u002Fhour, range 0.5–1.5.",[108],{"source":33,"section":100},[],[111],{"text":112,"refs":115},{"fa":113,"en":114},"برادی‌کاردی، افت فشار و ایست سینوسی؛ افزایش گذرای فشار با بارگذاری؛ قطع ناگهانی پس از مصرف طولانی علائم ترک می‌دهد.","Bradycardia, hypotension and sinus arrest; transient hypertension with loading; withdrawal on abrupt stop after prolonged use.",[116],{"source":33,"section":117},"5",[],[],[],{"status":122,"reviewer":123,"date":123},"unverified",null,[125,131,136],{"regimen":37,"formulation":23,"input":126,"expect":129},{"ageYears":127,"weightKg":128},60,70,{"perDose":128,"mlPerDose":130},17.5,{"regimen":61,"formulation":23,"input":132,"expect":133},{"ageYears":127,"weightKg":128},{"mlPerHour":134,"upperMlPerHour":135},3.5,12.25,{"regimen":89,"formulation":23,"input":137,"expect":140},{"ageYears":138,"weightKg":139},6,20,{"perDose":141,"mlPerDose":142},40,10,[144],"N05CM18",{"status":146,"forms":147,"refs":160},"registered",[148,152,156],{"code":149,"en":150,"fa":151},"17581","DEXMEDETOMIDINE 100MCG\u002F2ML VIAL","ویال دکسمدتومیدین ۱۰۰ میکروگرم \u002F ۲ میلی‌لیتر",{"code":153,"en":154,"fa":155},"52044","DEXMEDETOMIDINE (AS HYDROCHLORIDE) INJECTION PARENTERAL 4 ug\u002F1mL 100 mL","فرآورده تزریقی دکسمدتومیدین (معادل هیدروکلراید) ۴ میکروگرم \u002F ۱ میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":157,"en":158,"fa":159},"52043","DEXMEDETOMIDINE (AS HYDROCHLORIDE) INJECTION PARENTERAL 4 ug\u002F1mL 50 mL","فرآورده تزریقی دکسمدتومیدین (معادل هیدروکلراید) ۴ میکروگرم \u002F ۱ میلی‌لیتر ۵۰ میلی‌لیتر",[161],{"source":162,"section":163,"url":164},"darooyab-generic","G-1265\u002FDexmedetomidine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1265\u002FDexmedetomidine",{"kind":166,"refs":167,"id":170},"NDA",[168],{"source":33,"section":169},"SPL approval \u002F marketing category","NDA021038",[172,175,179,183,186,189],{"kind":173,"url":174,"label":170},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021038",{"kind":176,"url":177,"label":178},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=92b7ddaa-e45a-4b64-a802-bb5df8771dd6","FDA Precedex",{"kind":180,"url":181,"label":182},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625003.html","Dexmedetomidine Injection",{"kind":180,"url":184,"label":185},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa622074.html","Dexmedetomidine Sublingual and Buccal",{"kind":187,"url":188,"label":144},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05CM18",{"kind":190,"url":164,"label":8},"darooyab",{"pregnancy":192,"lactation":201,"pediatric":209,"geriatric":217},{"level":193,"text":194,"quote":197,"refs":198},"caution",{"fa":195,"en":196},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published randomized controlled trials and case reports over several decades of use with intravenously administered dexmedetomidine during pregnancy have not identified a drug-associated risk of major birth defects and miscarriage; however, the reported exposures occurred after the …",[199],{"source":33,"section":200},"8.1",{"level":193,"text":202,"quote":205,"refs":206},{"fa":203,"en":204},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Available published literature reports the presence of dexmedetomidine in human milk following intravenous administration (see Data ) .",[207],{"source":33,"section":208},"8.2",{"level":193,"text":210,"quote":213,"refs":214},{"fa":211,"en":212},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Sedation for Non-Invasive Procedures The safety and efficacy of PRECEDEX have been established in pediatric patients 1 month to less than 18 years of age for sedation during non-invasive procedures.",[215],{"source":33,"section":216},"8.4",{"level":193,"text":218,"quote":221,"refs":222},{"fa":219,"en":220},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In patients greater than 65 years of age, a higher incidence of bradycardia and hypotension was observed following administration of PRECEDEX [see Warnings and Precautions (5.2) ] .",[223],{"source":33,"section":224},"8.5",1792156173578]