[{"data":1,"prerenderedAt":191},["ShallowReactive",2],{"drug-dapsone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":18,"regimens":41,"contraindications":76,"warnings":86,"renal":94,"monitoring":95,"interactions":96,"review":97,"examples":100,"atc":110,"iran":112,"usApproval":132,"links":138,"populations":157},"dapsone",1,{"fa":7,"en":8},"داپسون","Dapsone","anti-infectives",{"fa":11,"en":12},"سولفون (ضدجذام)","Sulfone (antileprotic)",[14],{"name":8,"market":15},"US",[4,7,17],"DDS",[19,33],{"id":20,"form":21,"route":22,"label":23,"concentration":24,"markets":28,"refs":29},"tab-25","tablet","oral","25 mg tablet",{"amount":25,"unit":26,"perUnit":21,"scored":27},25,"mg",false,[15],[30],{"source":31,"section":32},"fda-dapsone","How Supplied",{"id":34,"form":21,"route":22,"label":35,"concentration":36,"markets":38,"refs":39},"tab-100","100 mg tablet",{"amount":37,"unit":26,"perUnit":21,"scored":27},100,[15],[40],{"source":31,"section":32},[42,57],{"id":43,"disease":44,"label":45,"population":48,"type":52,"unit":26,"dose":53,"refs":54},"lep","leprosy",{"fa":46,"en":47},"جذام — ۱۰۰ mg روزانه بدون وقفه همراه سایر داروهای ضدجذام","Leprosy — 100 mg daily without interruption, with other antileprosy drugs",{"minAge":49},{"value":50,"unit":51},18,"year","fixed",{"perDose":37,"dosesPerDay":5},[55],{"source":31,"section":56},"Dosage and Administration",{"id":58,"disease":59,"label":60,"population":63,"type":52,"unit":26,"dose":65,"refs":67,"notes":69},"dh","dermatitis-herpetiformis",{"fa":61,"en":62},"درماتیت هرپتی‌فرم — شروع ۵۰ mg روزانه (۵۰ تا ۳۰۰ mg)","Dermatitis herpetiformis — start 50 mg daily (50–300 mg)",{"minAge":64},{"value":50,"unit":51},{"perDose":66,"dosesPerDay":5},50,[68],{"source":31,"section":56},[70],{"text":71,"refs":74},{"fa":72,"en":73},"تیتراسیون تا کنترل؛ در اسرع وقت به کمترین دوز نگهدارنده کاهش. کودک دوز کمتر.","Titrate to control; reduce to the minimum maintenance dose as soon as possible. Children: smaller doses.",[75],{"source":31,"section":56},[77],{"id":78,"severity":79,"text":80,"refs":83},"hyper","block",{"fa":81,"en":82},"حساسیت به داپسون یا مشتقات آن.","Hypersensitivity to dapsone or its derivatives.",[84],{"source":31,"section":85},"Contraindications",[87],{"text":88,"refs":91},{"fa":89,"en":90},"آگرانولوسیتوز، آنمی آپلاستیک و دیسکرازی خونی کشنده — CBC مکرر؛ همولیز (به‌ویژه کمبود G6PD)؛ مت‌هموگلوبینمی.","Fatal agranulocytosis, aplastic anaemia and blood dyscrasias — frequent CBC; haemolysis (especially G6PD deficiency); methaemoglobinaemia.",[92],{"source":31,"section":93},"Warnings",[],[],[],{"status":98,"reviewer":99,"date":99},"unverified",null,[101,106],{"regimen":43,"formulation":34,"input":102,"expect":105},{"ageYears":103,"weightKg":104},40,60,{"perDose":37,"tabletsPerDoseRounded":5},{"regimen":58,"formulation":20,"input":107,"expect":108},{"ageYears":103,"weightKg":104},{"perDose":66,"tabletsPerDoseRounded":109},2,[111],"J04BA02",{"status":113,"forms":114,"refs":127},"registered",[115,119,123],{"code":116,"en":117,"fa":118},"00383","DAPSONE 100MG TAB","قرص داپسون ۱۰۰ میلی‌گرم",{"code":120,"en":121,"fa":122},"01456","DAPSONE 50MG TAB","قرص داپسون ۵۰ میلی‌گرم",{"code":124,"en":125,"fa":126},"51371","DAPSONE GEL TOPICAL 5 % 30 g","ژل موضعی داپسون ۵ درصد ۳۰ گرم",[128],{"source":129,"section":130,"url":131},"darooyab-generic","G-378\u002FDapsone","https:\u002F\u002Fwww.darooyab.ir\u002FG-378\u002FDapsone",{"kind":133,"refs":134,"id":137},"ANDA",[135],{"source":31,"section":136},"SPL approval \u002F marketing category","ANDA218335",[139,142,146,149,152,155],{"kind":140,"url":141,"label":137},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=218335",{"kind":143,"url":144,"label":145},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=839d7440-ba0e-4c56-b648-d374b155cf03","FDA Dapsone",{"kind":147,"url":148,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682128.html",{"kind":147,"url":150,"label":151},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa616045.html","Dapsone Topical",{"kind":153,"url":154,"label":111},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J04BA02",{"kind":156,"url":131,"label":8},"darooyab",{"pregnancy":158,"lactation":167,"pediatric":175,"geriatric":183},{"level":159,"text":160,"quote":163,"refs":164},"caution",{"fa":161,"en":162},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects: Animal reproduction studies have not been conducted with dapsone.",[165],{"source":31,"section":166},"Pregnancy:",{"level":159,"text":168,"quote":171,"refs":172},{"fa":169,"en":170},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Dapsone is excreted in breast milk in substantial amounts.",[173],{"source":31,"section":174},"Nursing Mothers:",{"level":159,"text":176,"quote":179,"refs":180},{"fa":177,"en":178},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Pediatric patients are treated on the same schedule as adults but with correspondingly smaller doses.",[181],{"source":31,"section":182},"Pediatric Use:",{"level":159,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","",[189],{"source":31,"section":190},"GERIATRIC USE",1792191535959]