[{"data":1,"prerenderedAt":201},["ShallowReactive",2],{"drug-conjugated-estrogens":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":68,"contraindications":84,"warnings":94,"renal":102,"monitoring":103,"interactions":104,"review":105,"examples":108,"atc":114,"iran":116,"links":140,"populations":162,"usApproval":196},"conjugated-estrogens",1,{"fa":7,"en":8},"استروژن کونژوگه (پرمارین)","Conjugated estrogens","genitourinary-sex-hormones",{"fa":11,"en":12},"استروژن","Oestrogen",[14],{"name":15,"market":16},"Premarin","US",[18,19,20],"premarin","پرمارین","استروژن کونژوگه",[22,36,44,52,60],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-0-3","tablet","oral","0.3 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},0.3,"mg",false,[16],[33],{"source":34,"section":35},"fda-premarin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-0-45","0.45 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},0.45,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-0-625","0.625 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},0.625,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"tab-0-9","0.9 mg tablet",{"amount":56,"unit":29,"perUnit":24,"scored":30},0.9,[16],[59],{"source":34,"section":35},{"id":61,"form":24,"route":25,"label":62,"concentration":63,"markets":65,"refs":66},"tab-1-25","1.25 mg tablet",{"amount":64,"unit":29,"perUnit":24,"scored":30},1.25,[16],[67],{"source":34,"section":35},[69],{"id":70,"disease":71,"label":72,"population":75,"type":79,"unit":29,"dose":80,"refs":81},"vms","menopause-symptoms",{"fa":73,"en":74},"گرگرفتگی یائسگی — شروع ۰٫۳ mg روزانه","Menopausal vasomotor symptoms — start 0.3 mg daily",{"minAge":76},{"value":77,"unit":78},40,"year","fixed",{"perDose":28,"dosesPerDay":5},[82],{"source":34,"section":83},"2.1",[85],{"id":86,"severity":87,"text":88,"refs":91},"ci","block",{"fa":89,"en":90},"خونریزی تناسلی تشخیص‌داده‌نشده؛ سرطان پستان یا وابسته به استروژن؛ DVT\u002FPE یا ترومبوز شریانی؛ بیماری کبد؛ بارداری.","Undiagnosed genital bleeding; breast or oestrogen-dependent cancer; DVT\u002FPE or arterial thrombosis; liver disease; pregnancy.",[92],{"source":34,"section":93},"4",[95],{"text":96,"refs":99},{"fa":97,"en":98},"هشدار جعبه‌ای: سرطان آندومتر (بدون پروژستین در رحم سالم)، حوادث قلبی‌عروقی، سرطان پستان و دمانس احتمالی؛ کمترین دوز و کوتاه‌ترین مدت.","Boxed warning: endometrial cancer (unopposed oestrogen with a uterus), cardiovascular disorders, breast cancer and probable dementia; lowest dose, shortest time.",[100],{"source":34,"section":101},"Boxed Warning",[],[],[],{"status":106,"reviewer":107,"date":107},"unverified",null,[109],{"regimen":70,"formulation":23,"input":110,"expect":113},{"ageYears":111,"weightKg":112},52,65,{"perDose":28,"tabletsPerDoseRounded":5},[115],"G03CA57",{"status":117,"forms":118,"refs":135},"registered",[119,123,127,131],{"code":120,"en":121,"fa":122},"00352","CONJUGATED ESTROGENS 0.625MG TAB","قرص کونژوگه استروژن‌ها ۰٫۶۲۵ میلی‌گرم",{"code":124,"en":125,"fa":126},"00353","CONJUGATED ESTROGENS 0.625MG\u002FG 42.5G VAG CREAM","کرم واژینال کونژوگه استروژن‌ها ۰٫۶۲۵ میلی‌گرم \u002F گرم ۴۲٫۵ گرم",{"code":128,"en":129,"fa":130},"00354","CONJUGATED ESTROGENS 1.25MG TAB","قرص کونژوگه استروژن‌ها ۱٫۲۵ میلی‌گرم",{"code":132,"en":133,"fa":134},"00355","CONJUGATED ESTROGENS 25MG\u002F5ML VIAL","ویال کونژوگه استروژن‌ها ۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر",[136],{"source":137,"section":138,"url":139},"darooyab-generic","G-3237\u002FConjugated-Estrogens","https:\u002F\u002Fwww.darooyab.ir\u002FG-3237\u002FConjugated-Estrogens",[141,145,149,153,156,159],{"kind":142,"url":143,"label":144},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=004782","NDA004782",{"kind":146,"url":147,"label":148},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=258e1602-a3cf-4ccc-ca80-73dbbfb812ff","FDA Premarin",{"kind":150,"url":151,"label":152},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682922.html","Estrogen",{"kind":150,"url":154,"label":155},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa606004.html","Estrogen Injection",{"kind":157,"url":158,"label":115},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03CA57",{"kind":160,"url":139,"label":161},"darooyab","Conjugated-Estrogens",{"pregnancy":163,"lactation":172,"pediatric":180,"geriatric":188},{"level":164,"text":165,"quote":168,"refs":169},"caution",{"fa":166,"en":167},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary PREMARIN is not indicated for use during pregnancy.",[170],{"source":34,"section":171},"8.1",{"level":164,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Estrogens and progestins and metabolites are present in human milk.",[178],{"source":34,"section":179},"8.2",{"level":164,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Estrogen therapy has been used for the induction of puberty in adolescents with some forms of pubertal delay.",[186],{"source":34,"section":187},"8.4",{"level":189,"text":190,"quote":193,"refs":194},"avoid",{"fa":191,"en":192},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA See full prescribing information for complete boxed warning.",[195],{"source":34,"section":101},{"kind":197,"refs":198,"id":144},"NDA",[199],{"source":34,"section":200},"SPL approval \u002F marketing category",1792092029296]