[{"data":1,"prerenderedAt":134},["ShallowReactive",2],{"drug-clomipramine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":44,"contraindications":95,"warnings":116,"renal":117,"monitoring":118,"interactions":119,"review":120,"examples":123},"clomipramine",1,{"fa":7,"en":8},"کلومیپرامین","Clomipramine","psychiatry",{"fa":11,"en":12},"ضدافسردگی سه‌حلقه‌ای","Tricyclic antidepressant",[14],{"name":15,"market":16},"Anafranil","US",[18,19,7,20],"anafranil","آنافرانیل","TCA",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"cap-25","capsule","oral","25 mg capsule",{"amount":28,"unit":29,"perUnit":24,"scored":30},25,"mg",false,[16],[33],{"source":34,"section":35},"fda-clomipramine","How Supplied",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"cap-50","50 mg capsule",{"amount":40,"unit":29,"perUnit":24,"scored":30},50,[16],[43],{"source":34,"section":35},[45,70],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":29,"dose":56,"refs":60,"notes":63},"adult","ocd",{"fa":49,"en":50},"OCD — بزرگسال: شروع ۲۵ mg روزانه","OCD — adults: start 25 mg daily",{"minAge":52},{"value":53,"unit":54},18,"year","titration",{"dividedDoses":5,"titration":57},{"start":28,"targetMin":58,"targetMax":58,"max":59},100,250,[61],{"source":34,"section":62},"Dosage and Administration",[64],{"text":65,"refs":68},{"fa":66,"en":67},"تا حدود ۱۰۰ mg طی ۲ هفته (منقسم با غذا)، سپس تدریجی تا حداکثر ۲۵۰ mg\u002Fday؛ پس از تیتراسیون یک‌جا هنگام خواب.","To about 100 mg over 2 weeks (divided, with meals), then gradually to max 250 mg\u002Fday; after titration once at bedtime.",[69],{"source":34,"section":62},{"id":71,"disease":47,"label":72,"population":75,"type":55,"unit":29,"dose":79,"refs":82,"limits":84,"notes":88},"peds",{"fa":73,"en":74},"OCD — کودکان و نوجوانان (۱۰ سال به بالا): شروع ۲۵ mg روزانه","OCD — children\u002Fadolescents (≥10 y): start 25 mg daily",{"minAge":76,"maxAge":78},{"value":77,"unit":54},10,{"value":53,"unit":54},{"dividedDoses":5,"titration":80},{"start":28,"max":81},200,[83],{"source":34,"section":62},{"maxPerKgPerDay":85,"refs":86},3,[87],{"source":34,"section":62},[89],{"text":90,"refs":93},{"fa":91,"en":92},"۲ هفته اول تا حداکثر ۳ mg\u002Fkg یا ۱۰۰ mg (هر کدام کمتر)؛ سپس تا ۳ mg\u002Fkg یا ۲۰۰ mg (هر کدام کمتر).","First 2 weeks up to 3 mg\u002Fkg or 100 mg (whichever smaller); then up to 3 mg\u002Fkg or 200 mg (whichever smaller).",[94],{"source":34,"section":62},[96,105],{"id":97,"severity":98,"text":99,"refs":102},"ci","block",{"fa":100,"en":101},"حساسیت به کلومیپرامین یا سایر TCAها؛ همراه یا تا ۱۴ روز پس از MAOI؛ دوره بهبود حاد پس از MI.","Hypersensitivity to clomipramine or other TCAs; with or within 14 days of an MAOI; acute recovery period after MI.",[103],{"source":34,"section":104},"Contraindications",{"id":106,"severity":107,"rule":108,"text":110,"refs":113},"suicide","warn",{"maxAge":109},{"value":28,"unit":54},{"fa":111,"en":112},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[114],{"source":34,"section":115},"Boxed Warning",[],[],[],[],{"status":121,"reviewer":122,"date":122},"unverified",null,[124,129],{"regimen":46,"formulation":23,"input":125,"expect":128},{"ageYears":126,"weightKg":127},30,70,{"perDose":28},{"regimen":71,"formulation":23,"input":130,"expect":133},{"ageYears":131,"weightKg":132},12,40,{"perDose":28},1792078533571]