[{"data":1,"prerenderedAt":172},["ShallowReactive",2],{"drug-cefotaxime":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":37,"contraindications":74,"warnings":84,"renal":85,"monitoring":86,"interactions":87,"review":88,"examples":91,"atc":92,"iran":94,"usApproval":114,"links":120,"populations":138},"cefotaxime",1,{"fa":7,"en":8},"سفوتاکسیم (تزریقی)","Cefotaxime (injection)","anti-infectives",{"fa":11,"en":12},"سفالوسپورین نسل سوم","Third-generation cephalosporin",[14],{"name":15,"market":16},"Claforan","US",[18,19,20,21],"claforan","کلافوران","سفوتاکسیم","آمپول سفوتاکسیم",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"vial-1g","powder-for-injection","iv","1 g vial (IM\u002FIV after reconstitution)",{"amount":29,"unit":30,"perUnit":31},1000,"mg","vial",[16],[34],{"source":35,"section":36},"fda-cefotaxime","How Supplied",[38,60],{"id":39,"disease":40,"label":41,"population":44,"type":52,"unit":30,"dose":53,"refs":57},"child","sepsis",{"fa":42,"en":43},"کودک ۱ ماه تا ۱۲ سال زیر ۵۰ kg — ۵۰ تا ۱۸۰ mg\u002Fkg\u002Fروز در ۴ تا ۶ دوز","Child 1 month–12 y, \u003C50 kg — 50–180 mg\u002Fkg\u002Fday in 4–6 doses",{"minAge":45,"maxAge":48,"maxWeightKg":51},{"value":46,"unit":47},29,"day",{"value":49,"unit":50},13,"year",49.99,"notCalculated",{"reason":54},{"fa":55,"en":56},"برچسب: ۵۰ تا ۱۸۰ mg\u002Fkg\u002Fروز عضلانی یا وریدی در ۴ تا ۶ دوز؛ دوز بالاتر برای عفونت شدید از جمله مننژیت. ۵۰ kg و بیشتر: دوز بزرگسال؛ حداکثر ۱۲ گرم در روز. حجم رقیق‌سازی طبق برچسب.","Label: 50–180 mg\u002Fkg\u002Fday IM or IV in 4–6 doses; higher doses for severe infection including meningitis. ≥50 kg: adult dose; max 12 g\u002Fday. Dilution per label.",[58],{"source":35,"section":59},"Dosage and Administration",{"id":61,"disease":40,"label":62,"population":65,"type":52,"unit":30,"dose":68,"refs":72},"adult",{"fa":63,"en":64},"بزرگسال — ۱ گرم هر ۱۲ ساعت تا ۲ گرم هر ۴ ساعت بسته به شدت","Adult — 1 g every 12 h up to 2 g every 4 h by severity",{"minAge":66},{"value":67,"unit":50},18,{"reason":69},{"fa":70,"en":71},"عفونت ساده: ۱ g هر ۱۲ ساعت؛ متوسط تا شدید: ۱ تا ۲ g هر ۸ ساعت؛ سپتی‌سمی: ۲ g هر ۶ تا ۸ ساعت؛ تهدیدکننده حیات: ۲ g هر ۴ ساعت؛ حداکثر ۱۲ g در روز. گنوره ساده: ۰٫۵ g عضلانی یک دوز.","Uncomplicated: 1 g every 12 h; moderate–severe: 1–2 g every 8 h; septicaemia: 2 g every 6–8 h; life-threatening: 2 g every 4 h; max 12 g\u002Fday. Uncomplicated gonorrhoea: 0.5 g IM once.",[73],{"source":35,"section":59},[75],{"id":76,"severity":77,"text":78,"refs":81},"hyper","block",{"fa":79,"en":80},"حساسیت به سفالوسپورین‌ها؛ در حساسیت به پنی‌سیلین با احتیاط.","Cephalosporin hypersensitivity; caution with penicillin allergy.",[82],{"source":35,"section":83},"Contraindications",[],[],[],[],{"status":89,"reviewer":90,"date":90},"unverified",null,[],[93],"J01DD01",{"status":95,"forms":96,"refs":109},"registered",[97,101,105],{"code":98,"en":99,"fa":100},"01336","CEFOTAXIME 1GR VIAL","ویال سفوتاکسیم ۱ گرم",{"code":102,"en":103,"fa":104},"13637","CEFOTAXIME 2GR VIAL","ویال سفوتاکسیم ۲ گرم",{"code":106,"en":107,"fa":108},"00229","CEFOTAXIME 500MG VIAL","ویال سفوتاکسیم ۵۰۰ میلی‌گرم",[110],{"source":111,"section":112,"url":113},"darooyab-generic","G-335\u002FCefotaxime","https:\u002F\u002Fwww.darooyab.ir\u002FG-335\u002FCefotaxime",{"kind":115,"refs":116,"id":119},"NDA",[117],{"source":35,"section":118},"SPL approval \u002F marketing category","NDA050547",[121,124,128,132,135],{"kind":122,"url":123,"label":119},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=050547",{"kind":125,"url":126,"label":127},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=434fb630-c8d6-4583-b3ee-8e4ba6552c3d","FDA Claforan",{"kind":129,"url":130,"label":131},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682765.html","Cefotaxime Injection",{"kind":133,"url":134,"label":93},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01DD01",{"kind":136,"url":113,"label":137},"darooyab","Cefotaxime",{"pregnancy":139,"lactation":148,"pediatric":156,"geriatric":164},{"level":140,"text":141,"quote":144,"refs":145},"caution",{"fa":142,"en":143},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Category B: Reproduction studies have been performed in pregnant mice given CLAFORAN intravenously at doses up to 1200 mg\u002Fkg\u002Fday (0.4 times the recommended human dose based on mg\u002Fm 2 ) or in pregnant rats when administered intravenously at doses up to 1200 mg\u002Fkg\u002Fday (0.8 times the recommended human dose based on mg\u002Fm …",[146],{"source":35,"section":147},"Precautions\u002FWarnings – Pregnancy",{"level":140,"text":149,"quote":152,"refs":153},{"fa":150,"en":151},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when CLAFORAN is administered to a nursing woman.",[154],{"source":35,"section":155},"Precautions\u002FWarnings – Nursing Mothers",{"level":140,"text":157,"quote":160,"refs":161},{"fa":158,"en":159},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See Precautions above regarding perivascular extravasation.",[162],{"source":35,"section":163},"Precautions\u002FWarnings – Pediatric Use",{"level":140,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see PRECAUTIONS, General ).",[170],{"source":35,"section":171},"Precautions\u002FWarnings – Geriatric Use",1792100096637]