[{"data":1,"prerenderedAt":247},["ShallowReactive",2],{"drug-caspofungin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":127,"warnings":137,"renal":138,"monitoring":139,"interactions":140,"review":149,"examples":152,"atc":170,"iran":172,"usApproval":188,"links":194,"populations":211},"caspofungin",1,{"fa":7,"en":8},"کاسپوفانژین","Caspofungin","anti-infectives",{"fa":11,"en":12},"اکینوکاندین (ضدقارچ)","Echinocandin antifungal",[14],{"name":15,"market":16},"Cancidas","US",[18,19,7],"cancidas","کانسیداس",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"vial-50","powder-for-injection","iv","50 mg vial",{"amount":27,"unit":28,"perUnit":29},50,"mg","vial",[16],[32],{"source":33,"section":34},"fda-cancidas","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"vial-70","70 mg vial",{"amount":39,"unit":28,"perUnit":29},70,[16],[42],{"source":33,"section":34},[44,61,83,102],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":56,"durationDays":59,"allowedFormulations":60},"load","invasive-fungal",{"fa":48,"en":49},"کاندیدمی، تب نوتروپنیک، آسپرژیلوز مقاوم — بزرگسال: روز ۱ دوز بارگذاری ۷۰ mg","Candidaemia, febrile neutropenia, refractory aspergillosis — adult: day 1 loading 70 mg",{"minAge":51},{"value":52,"unit":53},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[57],{"source":33,"section":58},"2.2",{"min":5,"max":5},[36],{"id":62,"disease":46,"label":63,"population":66,"type":54,"unit":28,"dose":68,"refs":69,"allowedFormulations":71,"notes":72},"maint",{"fa":64,"en":65},"نگهدارنده بزرگسال — ۵۰ mg یک بار در روز از روز ۲","Adult maintenance — 50 mg once daily from day 2",{"minAge":67},{"value":52,"unit":53},{"perDose":27,"dosesPerDay":5},[70],{"source":33,"section":58},[22],[73],{"text":74,"refs":77},{"fa":75,"en":76},"کاندیدمی: دست‌کم ۱۴ روز پس از آخرین کشت مثبت. نارسایی متوسط کبد: ۳۵ mg روزانه. انفوزیون ۱ ساعت؛ با دکستروز رقیق نشود.","Candidaemia: at least 14 days after the last positive culture. Moderate hepatic impairment: 35 mg daily. 1-hour infusion; no dextrose diluents.",[78,79,81],{"source":33,"section":58},{"source":33,"section":80},"2.4",{"source":33,"section":82},"2.7",{"id":84,"disease":85,"label":86,"population":89,"type":54,"unit":28,"dose":91,"refs":92,"allowedFormulations":94,"notes":95},"eso","esophageal-candidiasis",{"fa":87,"en":88},"کاندیدیاز مری — بزرگسال ۵۰ mg روزانه تا ۷ تا ۱۴ روز پس از بهبود","Oesophageal candidiasis — adult 50 mg daily until 7–14 days after symptoms resolve",{"minAge":90},{"value":52,"unit":53},{"perDose":27,"dosesPerDay":5},[93],{"source":33,"section":58},[22],[96],{"text":97,"refs":100},{"fa":98,"en":99},"بارگذاری ۷۰ mg در این اندیکاسیون بررسی نشده.","A 70 mg load has not been studied for this indication.",[101],{"source":33,"section":58},{"id":103,"disease":46,"label":104,"population":107,"type":112,"unit":28,"dose":113,"refs":114,"limits":117,"notes":120},"child",{"fa":105,"en":106},"کودک ۳ ماه تا ۱۷ سال — روز ۱: ۷۰ mg\u002Fm²، سپس ۵۰ mg\u002Fm² روزانه (حداکثر ۷۰ mg)","Children 3 months–17 y — day 1: 70 mg\u002Fm², then 50 mg\u002Fm² daily (max 70 mg)",{"minAge":108,"maxAge":111},{"value":109,"unit":110},3,"month",{"value":52,"unit":53},"bsa",{"perM2PerDay":27,"dividedDoses":5},[115],{"source":33,"section":116},"2.3",{"maxPerDose":39,"refs":118},[119],{"source":33,"section":116},[121],{"text":122,"refs":125},{"fa":123,"en":124},"عدد ماشین‌حساب دوز نگهدارنده ۵۰ mg\u002Fm² است؛ روز اول ۷۰ mg\u002Fm² (حداکثر ۷۰ mg). BSA با فرمول Mosteller.","The calculator gives the 50 mg\u002Fm² maintenance dose; day 1 is 70 mg\u002Fm² (max 70 mg). BSA by Mosteller.",[126],{"source":33,"section":116},[128],{"id":129,"severity":130,"text":131,"refs":134},"hyper","block",{"fa":132,"en":133},"حساسیت (مثلاً آنافیلاکسی) به اجزای فرآورده.","Hypersensitivity (e.g. anaphylaxis) to any component.",[135],{"source":33,"section":136},"4",[],[],[],[141],{"with":142,"text":143,"refs":146},"cyclosporine",{"fa":144,"en":145},"سیکلوسپورین: افزایش ALT — فقط اگر سود بیشتر باشد.","Cyclosporine: raised ALT — use only if benefit outweighs risk.",[147],{"source":33,"section":148},"5.3",{"status":150,"reviewer":151,"date":151},"unverified",null,[153,156,159,164],{"regimen":45,"formulation":36,"input":154,"expect":155},{"ageYears":27,"weightKg":39},{"perDose":39},{"regimen":62,"formulation":22,"input":157,"expect":158},{"ageYears":27,"weightKg":39},{"perDose":27},{"regimen":84,"formulation":22,"input":160,"expect":163},{"ageYears":161,"weightKg":162},40,60,{"perDose":27},{"regimen":103,"formulation":22,"input":165,"expect":169},{"ageYears":166,"weightKg":167,"heightCm":168},10,36,100,{"perDose":27},[171],"J02AX04",{"status":173,"forms":174,"refs":183},"registered",[175,179],{"code":176,"en":177,"fa":178},"06757","CASPOFUNGIN 50MG 10ML VIAL","ویال کاسپوفونجین ۵۰ میلی‌گرم ۱۰ میلی‌لیتر",{"code":180,"en":181,"fa":182},"06758","CASPOFUNGIN 70MG 10ML VIAL","ویال کاسپوفونجین ۷۰ میلی‌گرم ۱۰ میلی‌لیتر",[184],{"source":185,"section":186,"url":187},"darooyab-generic","G-702\u002FCaspofungin","https:\u002F\u002Fwww.darooyab.ir\u002FG-702\u002FCaspofungin",{"kind":189,"refs":190,"id":193},"NDA",[191],{"source":33,"section":192},"SPL approval \u002F marketing category","NDA021227",[195,198,202,206,209],{"kind":196,"url":197,"label":193},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021227",{"kind":199,"url":200,"label":201},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3bad23a6-09a6-4194-9182-093ed61bc71c","FDA Cancidas",{"kind":203,"url":204,"label":205},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa615001.html","Caspofungin Injection",{"kind":207,"url":208,"label":171},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J02AX04",{"kind":210,"url":187,"label":8},"darooyab",{"pregnancy":212,"lactation":221,"pediatric":230,"geriatric":238},{"level":213,"text":214,"quote":217,"refs":218},"avoid",{"fa":215,"en":216},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on animal data, CANCIDAS may cause fetal harm (see Data ) .",[219],{"source":33,"section":220},"8.1",{"level":222,"text":223,"quote":226,"refs":227},"caution",{"fa":224,"en":225},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of caspofungin in human milk, the effects on the breast-fed child, or the effects on milk production.",[228],{"source":33,"section":229},"8.2",{"level":222,"text":231,"quote":234,"refs":235},{"fa":232,"en":233},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of CANCIDAS in pediatric patients 3 months to 17 years of age are supported by evidence from adequate and well-controlled studies in adults, pharmacokinetic data in pediatric patients, and additional data from prospective studies in pediatric patients 3 months to 17 years of age for the …",[236],{"source":33,"section":237},"8.4",{"level":239,"text":240,"quote":243,"refs":244},"ok",{"fa":241,"en":242},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","Although the number of elderly patients was not large enough for a statistical analysis, no overall differences in safety or efficacy were observed between these and younger patients.",[245],{"source":33,"section":246},"8.5",1792156167510]