[{"data":1,"prerenderedAt":207},["ShallowReactive",2],{"drug-carboplatin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":33,"contraindications":76,"warnings":86,"renal":94,"monitoring":95,"interactions":96,"review":97,"examples":100,"atc":114,"iran":116,"usApproval":148,"links":154,"populations":171},"carboplatin",1,{"fa":7,"en":8},"کربوپلاتین","Carboplatin","antineoplastic-immunomodulating",{"fa":11,"en":12},"ترکیب پلاتین","Platinum compound",[14],{"name":15,"market":16},"Paraplatin","US",[18,7,4],"paraplatin",[20],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":28,"refs":29},"vial-10","injection","iv","10 mg\u002FmL (50\u002F150\u002F450\u002F600 mg)",{"amount":26,"unit":27,"perVolumeMl":5},10,"mg",[16],[30],{"source":31,"section":32},"fda-carboplatin","How Supplied",[34,64],{"id":35,"disease":36,"label":37,"population":40,"type":44,"unit":27,"dose":45,"refs":47,"durationDays":50,"notes":51},"mono","ovarian-cancer",{"fa":38,"en":39},"سرطان عودکننده تخمدان (تک‌دارو) — ۳۶۰ mg\u002Fm² روز ۱ هر ۴ هفته","Recurrent ovarian cancer (single agent) — 360 mg\u002Fm² on day 1 every 4 weeks",{"minAge":41},{"value":42,"unit":43},18,"year","bsa",{"perM2PerDay":46,"dividedDoses":5},360,[48],{"source":31,"section":49},"Dosage and Administration",{"min":5,"max":5},[52,58],{"text":53,"refs":56},{"fa":54,"en":55},"جایگزین: دوز بر اساس فرمول (Calvert: AUC × [GFR + ۲۵]). تا نوتروفیل ≥۲۰۰۰ و پلاکت ≥۱۰۰ هزار تکرار نشود.","Alternative: formula dosing (Calvert: AUC × [GFR + 25]). Do not repeat until neutrophils ≥2,000 and platelets ≥100,000.",[57],{"source":31,"section":49},{"text":59,"refs":62},{"fa":60,"en":61},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[63],{"source":31,"section":49},{"id":65,"disease":36,"label":66,"population":69,"type":44,"unit":27,"dose":71,"refs":73,"durationDays":75},"combo",{"fa":67,"en":68},"سرطان پیشرفته تخمدان (با سیکلوفسفامید) — ۳۰۰ mg\u002Fm² روز ۱ هر ۴ هفته، ۶ دوره","Advanced ovarian cancer (with cyclophosphamide) — 300 mg\u002Fm² on day 1 every 4 weeks for 6 cycles",{"minAge":70},{"value":42,"unit":43},{"perM2PerDay":72,"dividedDoses":5},300,[74],{"source":31,"section":49},{"min":5,"max":5},[77],{"id":78,"severity":79,"text":80,"refs":83},"ci","block",{"fa":81,"en":82},"سابقه آلرژی شدید به سیس‌پلاتین یا سایر ترکیبات پلاتین؛ سرکوب شدید مغز استخوان یا خونریزی قابل‌توجه.","History of severe allergy to cisplatin or other platinum compounds; severe bone-marrow depression or significant bleeding.",[84],{"source":31,"section":85},"Contraindications",[87],{"text":88,"refs":91},{"fa":89,"en":90},"هشدار جعبه‌ای: سرکوب مغز استخوان (عفونت، خونریزی)، استفراغ، واکنش شبه‌آنافیلاکسی ظرف چند دقیقه.","Boxed warning: bone-marrow suppression (infection, bleeding), vomiting, anaphylactic-like reactions within minutes.",[92],{"source":31,"section":93},"Warnings",[],[],[],{"status":98,"reviewer":99,"date":99},"unverified",null,[101,109],{"regimen":35,"formulation":21,"input":102,"expect":106},{"ageYears":103,"weightKg":104,"heightCm":105},55,80,180,{"perDose":107,"mlPerDose":108},720,72,{"regimen":65,"formulation":21,"input":110,"expect":111},{"ageYears":103,"weightKg":104,"heightCm":105},{"perDose":112,"mlPerDose":113},600,60,[115],"L01XA02",{"status":117,"forms":118,"refs":143},"registered",[119,123,127,131,135,139],{"code":120,"en":121,"fa":122},"00214","CARBOPLATIN 150MG VIAL","ویال کربوپلاتین ۱۵۰ میلی‌گرم",{"code":124,"en":125,"fa":126},"02376","CARBOPLATIN 150MG\u002F15ML AMP","آمپول کربوپلاتین ۱۵۰ میلی‌گرم \u002F ۱۵ میلی‌لیتر",{"code":128,"en":129,"fa":130},"13830","CARBOPLATIN 450MG\u002F45ML VIAL","ویال کربوپلاتین ۴۵۰ میلی‌گرم \u002F ۴۵ میلی‌لیتر",{"code":132,"en":133,"fa":134},"13458","CARBOPLATIN 50MG AMP","آمپول کربوپلاتین ۵۰ میلی‌گرم",{"code":136,"en":137,"fa":138},"00215","CARBOPLATIN 50MG VIAL","ویال کربوپلاتین ۵۰ میلی‌گرم",{"code":140,"en":141,"fa":142},"02375","CARBOPLATIN 50MG\u002F5ML VIAL","ویال کربوپلاتین ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",[144],{"source":145,"section":146,"url":147},"darooyab-generic","G-962\u002FCarboplatin","https:\u002F\u002Fwww.darooyab.ir\u002FG-962\u002FCarboplatin",{"kind":149,"refs":150,"id":153},"ANDA",[151],{"source":31,"section":152},"SPL approval \u002F marketing category","ANDA077861",[155,158,162,166,169],{"kind":156,"url":157,"label":153},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=077861",{"kind":159,"url":160,"label":161},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4c89cedc-e48b-445c-ad05-54dbe60e4fb0","FDA Carboplatin",{"kind":163,"url":164,"label":165},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695017.html","Carboplatin Injection",{"kind":167,"url":168,"label":115},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01XA02",{"kind":170,"url":147,"label":8},"darooyab",{"pregnancy":172,"lactation":181,"pediatric":190,"geriatric":199},{"level":173,"text":174,"quote":177,"refs":178},"avoid",{"fa":175,"en":176},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Pregnancy Category D See WARNINGS.",[179],{"source":31,"section":180},"Pregnancy",{"level":182,"text":183,"quote":186,"refs":187},"caution",{"fa":184,"en":185},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because there is a possibility of toxicity in nursing infants secondary to carboplatin treatment of the mother, it is recommended that breast-feeding be discontinued if the mother is treated with carboplatin injection.",[188],{"source":31,"section":189},"Nursing Mothers",{"level":191,"text":192,"quote":195,"refs":196},"not-established",{"fa":193,"en":194},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established (see WARNINGS : \"audiologic toxicity\").",[197],{"source":31,"section":198},"Pediatric Use",{"level":182,"text":200,"quote":203,"refs":204},{"fa":201,"en":202},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the 789 patients in initial treatment combination therapy studies (NCIC and SWOG), 395 patients were treated with carboplatin in combination with cyclophosphamide.",[205],{"source":31,"section":206},"Geriatric Use",1792444385805]