[{"data":1,"prerenderedAt":143},["ShallowReactive",2],{"drug-carbamazepine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":103,"warnings":113,"renal":121,"monitoring":122,"interactions":123,"review":124,"examples":127},"carbamazepine",1,{"fa":7,"en":8},"کاربامازپین","Carbamazepine","psychiatry",{"fa":11,"en":12},"ضدتشنج","Anticonvulsant",[14],{"name":15,"market":16},"Tegretol","US",[18,19,7],"tegretol","تگرتول",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-200","tablet","oral","200 mg tablet (partially scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},200,"mg",true,[16],[32],{"source":33,"section":34},"fda-carbamazepine","How Supplied",[36,65,86],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":51,"limits":54,"notes":58},"epi-lt6","epilepsy",{"fa":40,"en":41},"صرع — زیر ۶ سال: شروع ۱۰ تا ۲۰ mg\u002Fkg\u002Fday","Epilepsy — under 6 y: start 10–20 mg\u002Fkg\u002Fday",{"maxAge":43},{"value":44,"unit":45},6,"year","weightBased",{"perKgPerDay":48,"perKgPerDayMax":49,"dividedDoses":50},10,20,2,[52],{"source":33,"section":53},"Dosage and Administration",{"maxPerKgPerDay":55,"refs":56},35,[57],{"source":33,"section":53},[59],{"text":60,"refs":63},{"fa":61,"en":62},"هفتگی تا پاسخ مطلوب افزایش؛ معمولاً پاسخ زیر ۳۵ mg\u002Fkg\u002Fday؛ قرص دو یا سه بار در روز.","Increase weekly to response; usually below 35 mg\u002Fkg\u002Fday; tablets 2–3 times daily.",[64],{"source":33,"section":53},{"id":66,"disease":38,"label":67,"population":70,"type":74,"unit":28,"dose":75,"refs":77,"notes":79},"epi-6-12",{"fa":68,"en":69},"صرع — ۶ تا ۱۲ سال: شروع ۱۰۰ mg دو بار در روز","Epilepsy — 6–12 y: start 100 mg twice daily",{"minAge":71,"maxAge":72},{"value":44,"unit":45},{"value":73,"unit":45},13,"fixed",{"perDose":76,"dosesPerDay":50},100,[78],{"source":33,"section":53},[80],{"text":81,"refs":84},{"fa":82,"en":83},"افزایش هفتگی تا ۱۰۰ mg\u002Fday.","Increase weekly by up to 100 mg\u002Fday.",[85],{"source":33,"section":53},{"id":87,"disease":38,"label":88,"population":91,"type":74,"unit":28,"dose":93,"refs":94,"notes":96},"epi-12plus",{"fa":89,"en":90},"صرع — بزرگسال و بالای ۱۲ سال: شروع ۲۰۰ mg دو بار در روز","Epilepsy — adults and >12 y: start 200 mg twice daily",{"minAge":92},{"value":73,"unit":45},{"perDose":27,"dosesPerDay":50},[95],{"source":33,"section":53},[97],{"text":98,"refs":101},{"fa":99,"en":100},"افزایش هفتگی تا ۲۰۰ mg\u002Fday.","Increase weekly by up to 200 mg\u002Fday.",[102],{"source":33,"section":53},[104],{"id":105,"severity":106,"text":107,"refs":110},"ci","block",{"fa":108,"en":109},"سابقه سرکوب مغز استخوان؛ حساسیت به کاربامازپین یا ضدافسردگی‌های سه‌حلقه‌ای؛ MAOI.","History of bone marrow depression; hypersensitivity to carbamazepine or tricyclics; MAOIs.",[111],{"source":33,"section":112},"Contraindications",[114],{"text":115,"refs":118},{"fa":116,"en":117},"هشدار جعبه‌ای: واکنش‌های پوستی کشنده (SJS\u002FTEN) مرتبط با آلل HLA-B*1502 (خطر حدود ۱۰ برابر در برخی جمعیت‌های آسیایی)؛ آپلاستیک آنمی و آگرانولوسیتوز.","Boxed warning: fatal skin reactions (SJS\u002FTEN) linked to HLA-B*1502 (about 10× risk in some Asian populations); aplastic anemia and agranulocytosis.",[119],{"source":33,"section":120},"WARNINGS (boxed): SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE",[],[],[],{"status":125,"reviewer":126,"date":126},"unverified",null,[128,133,138],{"regimen":37,"formulation":22,"input":129,"expect":131},{"ageYears":130,"weightKg":49},4,{"perDose":76,"tabletsPerDoseRounded":132},0.5,{"regimen":66,"formulation":22,"input":134,"expect":137},{"ageYears":135,"weightKg":136},8,25,{"tabletsPerDoseRounded":132},{"regimen":87,"formulation":22,"input":139,"expect":142},{"ageYears":140,"weightKg":141},30,70,{"tabletsPerDoseRounded":5},1792078532548]