[{"data":1,"prerenderedAt":170},["ShallowReactive",2],{"drug-brimonidine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":34,"contraindications":58,"warnings":77,"renal":78,"monitoring":79,"interactions":80,"review":81,"examples":84,"atc":90,"iran":92,"links":116,"populations":131,"usApproval":165},"brimonidine",1,{"fa":7,"en":8},"قطره چشمی بریمونیدین","Brimonidine eye drops","sensory-organs",{"fa":11,"en":12},"آگونیست α2 (کاهش فشار چشم)","α2 agonist (IOP-lowering)",[14],{"name":15,"market":16},"Alphagan P","US",[18,19,20],"alphagan","آلفاگان","بریمونیدین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":29,"refs":30},"sol-01","eye-drops","ophthalmic","Brimonidine tartrate 0.1% eye drops",{"amount":5,"unit":28,"perUnit":28},"drop",[16],[31],{"source":32,"section":33},"fda-brimonidine","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":48,"notes":51},"iop","glaucoma",{"fa":39,"en":40},"گلوکوم زاویه باز یا فشار بالای چشم — یک قطره ۳ بار در روز (هر ۸ ساعت)","Open-angle glaucoma or ocular hypertension — 1 drop three times daily (every 8 h)",{"minAge":42},{"value":43,"unit":44},2,"year","fixed",{"perDose":5,"dosesPerDay":47},3,[49],{"source":32,"section":50},"2",[52],{"text":53,"refs":56},{"fa":54,"en":55},"با سایر قطره‌ها دست‌کم ۵ دقیقه فاصله.","At least 5 minutes apart from other eye drops.",[57],{"source":32,"section":50},[59,70],{"id":60,"severity":61,"text":62,"refs":65,"rule":68},"infant","block",{"fa":63,"en":64},"نوزاد و شیرخوار زیر ۲ سال.","Neonates and infants under 2 years.",[66],{"source":32,"section":67},"4",{"maxAge":69},{"value":43,"unit":44},{"id":71,"severity":61,"text":72,"refs":75},"hyper",{"fa":73,"en":74},"واکنش حساسیتی قبلی.","Previous hypersensitivity reaction.",[76],{"source":32,"section":67},[],[],[],[],{"status":82,"reviewer":83,"date":83},"unverified",null,[85],{"regimen":36,"formulation":23,"input":86,"expect":89},{"ageYears":87,"weightKg":88},60,70,{"perDose":5,"dosesPerDay":47},[91],"S01EA05",{"status":93,"forms":94,"refs":111},"registered",[95,99,103,107],{"code":96,"en":97,"fa":98},"18369","BRIMONIDINE 1.3 MG +TIMOLOL 0.5 MG  DROP","قطره بریمونیدین ۱٫۳ میلی‌گرم + تیمولول ۰٫۵ میلی‌گرم",{"code":100,"en":101,"fa":102},"11459","BRIMONIDINE TARTRATE 0.2% OPH DROP","قطره چشمی بریمونیدین تارتارات ۰٫۲ درصد",{"code":104,"en":105,"fa":106},"02028","BRIMONIDINE TARTRATE 1% 5ML OPH DROP","قطره چشمی بریمونیدین تارتارات ۱ درصد ۵ میلی‌لیتر",{"code":108,"en":109,"fa":110},"52430","BRIMONIDINE (AS TARTRATE) GEL TOPICAL 3 mg\u002F1g 30 g","ژل موضعی بریمونیدین (معادل تارتارات) ۳ میلی‌گرم \u002F ۱ گرم ۳۰ گرم",[112],{"source":113,"section":114,"url":115},"darooyab-generic","G-1565\u002FBrimonidine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1565\u002FBrimonidine",[117,121,125,128],{"kind":118,"url":119,"label":120},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=220398","ANDA220398",{"kind":122,"url":123,"label":124},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f6666d85-f810-4869-993d-e8ae35b4517f","FDA Brimonidine 0.1%",{"kind":126,"url":127,"label":91},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=S01EA05",{"kind":129,"url":115,"label":130},"darooyab","Brimonidine",{"pregnancy":132,"lactation":141,"pediatric":149,"geriatric":156},{"level":133,"text":134,"quote":137,"refs":138},"caution",{"fa":135,"en":136},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate and well-controlled studies with brimonidine tartrate ophthalmic solution in pregnant women.",[139],{"source":32,"section":140},"8.1",{"level":133,"text":142,"quote":145,"refs":146},{"fa":143,"en":144},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","In animal studies, brimonidine tartrate has been shown to cross the blood-brain barrier and is excreted into breast milk after oral administration to lactating rats (see Data) .",[147],{"source":32,"section":148},"8.2",{"level":133,"text":150,"quote":153,"refs":154},{"fa":151,"en":152},"برچسب: زیر ۲ سال ممنوع؛ از ۲ سالگی با احتیاط.","Label: contraindicated under 2 years; use with caution from 2 years.","Neonates and infants (pediatric patients younger than 2 years old).",[155],{"source":32,"section":67},{"level":157,"text":158,"quote":161,"refs":162},"ok",{"fa":159,"en":160},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness have been observed between elderly and other adult patients.",[163],{"source":32,"section":164},"8.5",{"kind":166,"refs":167,"id":120},"ANDA",[168],{"source":32,"section":169},"SPL approval \u002F marketing category",1792115170074]