[{"data":1,"prerenderedAt":163},["ShallowReactive",2],{"drug-bempedoic-acid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":59,"warnings":69,"renal":77,"monitoring":78,"interactions":79,"review":80,"examples":83,"atc":89,"iran":91,"usApproval":103,"links":109,"populations":127},"bempedoic-acid",1,{"fa":7,"en":8},"بمپدوئیک اسید","Bempedoic acid","cardiovascular",{"fa":11,"en":12},"مهارکننده ACL (کاهش LDL)","ACL inhibitor (LDL-lowering)",[14],{"name":15,"market":16},"Nexletol","US",[18,19,20],"nexletol","نکسلتول","بمپدوئیک",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-180","tablet","oral","180 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},180,"mg",false,[16],[33],{"source":34,"section":35},"fda-nexletol","3",[37],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":29,"dose":48,"refs":49,"notes":52},"ldl","hyperlipidemia",{"fa":41,"en":42},"هیپرکلسترولمی یا پیشگیری قلبی — ۱۸۰ mg یک بار در روز","Hypercholesterolaemia or CV risk reduction — 180 mg once daily",{"minAge":44},{"value":45,"unit":46},18,"year","fixed",{"perDose":28,"dosesPerDay":5},[50],{"source":34,"section":51},"2.1",[53],{"text":54,"refs":57},{"fa":55,"en":56},"چربی خون ۸ تا ۱۲ هفته پس از شروع.","Check lipids 8–12 weeks after starting.",[58],{"source":34,"section":51},[60],{"id":61,"severity":62,"text":63,"refs":66},"hyper","block",{"fa":64,"en":65},"سابقه حساسیت جدی به بمپدوئیک اسید.","History of serious hypersensitivity to bempedoic acid.",[67],{"source":34,"section":68},"4",[70],{"text":71,"refs":74},{"fa":72,"en":73},"افزایش اسید اوریک و نقرس؛ پارگی تاندون؛ با سیمواستاتین بالای ۲۰ mg یا پراواستاتین بالای ۴۰ mg نه.","Hyperuricaemia and gout; tendon rupture; avoid simvastatin >20 mg or pravastatin >40 mg.",[75],{"source":34,"section":76},"5",[],[],[],{"status":81,"reviewer":82,"date":82},"unverified",null,[84],{"regimen":38,"formulation":23,"input":85,"expect":88},{"ageYears":86,"weightKg":87},60,80,{"perDose":28,"tabletsPerDoseRounded":5},[90],"C10AX15",{"status":92,"forms":93,"refs":98},"registered",[94],{"code":95,"en":96,"fa":97},"53341","BEMPEDOIC ACID  180 mg TABLET","قرص بمپدوئیک اسید ۱۸۰ میلی‌گرم",[99],{"source":100,"section":101,"url":102},"darooyab-generic","G-1914\u002FBempedoic-acid","https:\u002F\u002Fwww.darooyab.ir\u002FG-1914\u002FBempedoic-acid",{"kind":104,"refs":105,"id":108},"NDA",[106],{"source":34,"section":107},"SPL approval \u002F marketing category","NDA211616",[110,113,117,121,124],{"kind":111,"url":112,"label":108},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=211616",{"kind":114,"url":115,"label":116},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=88d06d89-a3da-40b4-b273-8f4f7d56c4c9","FDA Nexletol",{"kind":118,"url":119,"label":120},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa620020.html","Bempedoic Acid",{"kind":122,"url":123,"label":90},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C10AX15",{"kind":125,"url":102,"label":126},"darooyab","Bempedoic-acid",{"pregnancy":128,"lactation":137,"pediatric":146,"geriatric":154},{"level":129,"text":130,"quote":133,"refs":134},"avoid",{"fa":131,"en":132},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","NEXLETOL decreases cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol; therefore, NEXLETOL may cause fetal harm when administered to pregnant women based on the mechanism of action [see Clinical Pharmacology (12.1) ] .",[135],{"source":34,"section":136},"8.1",{"level":138,"text":139,"quote":142,"refs":143},"caution",{"fa":140,"en":141},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Bempedoic acid was detected in breast milk of lactating women who received six consecutive daily doses of 180 mg bempedoic acid.",[144],{"source":34,"section":145},"8.2",{"level":138,"text":147,"quote":150,"refs":151},{"fa":148,"en":149},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of NEXLETOL have not been established in pediatric patients.",[152],{"source":34,"section":153},"8.4",{"level":155,"text":156,"quote":159,"refs":160},"ok",{"fa":157,"en":158},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness of NEXLETOL have been observed between patients 65 years of age and older and younger adult patients.",[161],{"source":34,"section":162},"8.5",1792156164181]